Comparison of Monte Carlo simulations of cytochrome b6f with experiment using Latin hypercube sampling.

abstract：:Recent advances in virology, gene therapy, and molecular and cell biology have provided insight into the mechanisms through which viruses can boost the anti-tumor immune response, or can infect and directly kill tumor cells. A recent experimental report (Bridle et al. in Molec. Ther. 18(8):1430-1439, 2010) showed that...

journal_title：Bulletin of mathematical biology

authors： Eftimie R,Dushoff J,Bridle BW,Bramson JL,Earn DJ

更新日期：2011-12-01 00:00:00

abstract：:Identifiability concerns finding which unknown parameters of a model can be estimated, uniquely or otherwise, from given input-output data. If some subset of the parameters of a model cannot be determined given input-output data, then we say the model is unidentifiable. In this work, we study linear compartment models...

journal_title：Bulletin of mathematical biology

authors： Meshkat N,Sullivant S,Eisenberg M

更新日期：2015-08-01 00:00:00

abstract：:This study investigates fluid flow and elastic deformation in tissues that are drained by the primary lymphatic system. A model is formulated based on the Rossi hypothesis that states that the primary lymphatic valves, which are formed by overlapping endothelial cells around the circumferential lining of lymphatic cap...

journal_title：Bulletin of mathematical biology

authors： Heppell C,Roose T,Richardson G

更新日期：2015-06-01 00:00:00

abstract：:Doxorubicin treatment outcomes for non-Hodgkin's lymphomas (NHL) are mathematically modelled and computationally analyzed. The NHL model includes a tumor structure incorporating mature and immature vessels, vascular structural adaptation and NHL cell-cycle kinetics in addition to Doxorubicin pharmacokinetics (PK) and ...

journal_title：Bulletin of mathematical biology

authors： Ribba B,Marron K,Agur Z,Alarcón T,Maini PK

更新日期：2005-01-01 00:00:00

abstract：:Many aquatic organisms detect the presence of moving objects in their environment, such as predators, by sensing the hydrodynamic disturbances the movements produce. The resultant water flow is readily detectable by stationary organisms, but free-swimming organisms are carried with the surrounding water and may not de...

journal_title：Bulletin of mathematical biology

authors： Takagi D,Hartline DK

更新日期：2018-01-01 00:00:00

abstract：:We develop the mathematical machinery for the construction of an algebraic-combinatorial model using Petri nets to construct an oriented matroid representation of biochemical pathways. For demonstration purposes, we use a model metabolic pathway example from the literature to derive a general biochemical reaction netw...

journal_title：Bulletin of mathematical biology

authors： Oliveira JS,Bailey CG,Jones-Oliveira JB,Dixon DA

更新日期：2001-11-01 00:00:00

abstract：:We derive point and interval estimates for an urban population of green tree frogs (Hyla cinerea) from capture-mark-recapture field data obtained during the years 2006-2009. We present an infinite-dimensional least-squares approach which compares a mathematical population model to the statistical population estimates ...

journal_title：Bulletin of mathematical biology

authors： Ackleh AS,Carter J,Deng K,Huang Q,Pal N,Yang X

更新日期：2012-03-01 00:00:00

abstract：:Previous models of the renal concentrating mechanism employ ideal approximations of solution thermodynamics for membrane transport calculation. In three-dimensional models of the renal medulla, predicted urine concentrations reach levels where these idealized approximations begin to break down. In this paper we derive...

journal_title：Bulletin of mathematical biology

authors： Wang X,Wexler AS,Marsh DJ

更新日期：1994-05-01 00:00:00

abstract：:In this paper we attack the problem of understanding the localization of the main structures involved in the motor circadian rhythm of crayfish by analysing its ontogeny. We present experimental results giving the properties of this rhythm in young and adult crayfish. Then we construct a mathematical model (based on a...

journal_title：Bulletin of mathematical biology

authors： Fuentes-Pardo B,Lara-Aparicio M,López de Medrano S

更新日期：2001-03-01 00:00:00

abstract：:Nosocomial outbreaks of bacteria are well documented. Based on these incidents, and the heavy usage of antibiotics in hospitals, it has been assumed that antibiotic resistance evolves in hospital environments. To test this assumption, we studied resistance phenotypes of bacteria collected from patient isolates at a co...

journal_title：Bulletin of mathematical biology

authors： Seigal A,Mira P,Sturmfels B,Barlow M

更新日期：2017-01-01 00:00:00

abstract：:Understanding the life-history complex of eusociality has remained an enduring problem in evolutionary ecology, partially because natural selection models have considered traits in relative isolation. I aim for a more inclusive model that uses ecological interactions to predict the evolutionary existence of sexual rep...

journal_title：Bulletin of mathematical biology

authors： Witting L

更新日期：2007-05-01 00:00:00

abstract：:When two strings of symbols are aligned it is important to know whether the observed number of matches is better than that expected between two independent sequences with the same frequency of symbols. When strings are of different lengths, nulls need to be inserted in order to align the sequences. One approach is to ...

journal_title：Bulletin of mathematical biology

authors： Rinsma I,Hendy M,Penny D

更新日期：1990-01-01 00:00:00

abstract：:Evidence suggests that many G protein-coupled receptors (GPCRs) are bound together forming dimers. The implications of dimerisation for cellular signalling outcomes, and ultimately drug discovery and therapeutics, remain unclear. Consideration of ligand binding and signalling via receptor dimers is therefore required ...

journal_title：Bulletin of mathematical biology

authors： White C,Bridge LJ

更新日期：2019-09-01 00:00:00

abstract：:Microtubules (MTs) are protein filaments found in all eukaryotic cells which are crucial for many cellular processes including cell movement, cell differentiation, and cell division. Due to their role in cell division, they are often used as targets for chemotherapy drugs used in cancer treatment. Experimental studies...

journal_title：Bulletin of mathematical biology

authors： Honoré S,Hubert F,Tournus M,White D

更新日期：2019-03-01 00:00:00

abstract：:One of the main challenges in systems biology is the establishment of the metabolome: a catalogue of the metabolites and biochemical reactions present in a specific organism. Current knowledge of biochemical pathways as stored in public databases such as KEGG, is based on carefully curated genomic evidence for the pre...

journal_title：Bulletin of mathematical biology

authors： Félix L,Rosselló F,Valiente G

更新日期：2009-04-01 00:00:00

abstract：:Human T-cell lymphotropic virus type I (HTLV-I) infection in humans causes a chronic infection of CD4+ T cells, and is associated with various disease outcomes, among them with the development of adult T-cell leukemia (ATL). The T-cell dynamics after HTLV-I infection can be described in a mathematical model with coupl...

journal_title：Bulletin of mathematical biology

authors： Stilianakis NI,Seydel J

更新日期：1999-09-01 00:00:00

abstract：:Preserving a system's viability in the presence of diversity erosion is critical if the goal is to sustainably support biodiversity. Reduction in population heterogeneity, whether inter- or intraspecies, may increase population fragility, either decreasing its ability to adapt effectively to environmental changes or f...

journal_title：Bulletin of mathematical biology

authors： Kareva I,Morin B,Castillo-Chavez C

更新日期：2015-02-01 00:00:00

abstract：:It has been postulated that fibroblast growth factor (FGF) treatment of cultured limb bud mesenchyme cells reinforces the lateral inhibitory effect, but the cells also show accelerated pattern appearance. In the present study, we analyze how a small change in a specific parameter affects the speed of pattern appearanc...

journal_title：Bulletin of mathematical biology

authors： Miura T,Maini PK

更新日期：2004-07-01 00:00:00

abstract：:Understanding how ecosystems evolve and how they respond to external perturbations is critical if we are to predict the effects of human intervention. A particular class of ecosystems whose dynamics are poorly understood are those in which the species are related via cross-feeding. In these ecosystems the metabolic ou...

journal_title：Bulletin of mathematical biology

authors： Lundh T,Gerlee P

更新日期：2013-05-01 00:00:00

abstract：:In developmental biology as well as in other biological systems, emerging structure and organization can be captured using time-series data of protein locations. In analyzing this time-dependent data, it is a common challenge not only to determine whether topological features emerge, but also to identify the timing of...

journal_title：Bulletin of mathematical biology

authors： Ciocanel MV,Juenemann R,Dawes AT,McKinley SA

更新日期：2021-01-16 00:00:00

abstract：:Integrins mediate cell adhesion and are essential receptors for the development and functioning of multicellular organisms. Integrin activation is known to require both ligand and talin binding and to correlate with cluster formation but the activation mechanism and precise roles of these processes are not yet resolve...

journal_title：Bulletin of mathematical biology

authors： Iber D,Campbell ID

更新日期：2006-05-01 00:00:00

abstract：:The tumour suppressor gene, p53, plays an important role in tumour development. Under low levels of oxygen (hypoxia), cells expressing wild-type p53 undergo programmed cell death (apoptosis), whereas cells expressing mutations in the p53 gene may survive and express angiogenic growth factors that stimulate tumour vasc...

journal_title：Bulletin of mathematical biology

authors： Gammack D,Byrne HM,Lewis CE

更新日期：2001-01-01 00:00:00

abstract：:Collective dynamics of migrating cell populations drive key processes in tissue formation and maintenance under normal and diseased conditions. Collective cell behavior at the tissue level is typically characterized by considering cell density patterns such as clusters and moving cell fronts. However, there are also i...

journal_title：Bulletin of mathematical biology

authors： Mente C,Voss-Böhme A,Deutsch A

更新日期：2015-04-01 00:00:00

abstract：:Premised on relatively simple assumptions, mathematical models like those of Monod, Pirt or Droop inadequately explain the complex transient behavior of microbial populations. In particular, these models fail to explain many aspects of the dynamics of a Tetrahymena pyriformis-Escherichia coli community. In this study ...

journal_title：Bulletin of mathematical biology

authors： Jaworska JS,Hallam TG,Schultz TW

更新日期：1996-03-01 00:00:00

abstract：:Bacterial quorum sensing (QS) is a form of intercellular communication that relies on the production and detection of diffusive signaling molecules called autoinducers. Such a mechanism allows the bacteria to track their cell density in order to regulate group behavior, such as biofilm formation and bioluminescence. I...

journal_title：Bulletin of mathematical biology

authors： Fan G,Bressloff PC

更新日期：2019-05-01 00:00:00

abstract：:Cell motility is an essential phenomenon in almost all living organisms. It is natural to think that behavioral or shape changes of a cell bear information about the underlying mechanisms that generate these changes. Reading cell motion, namely, understanding the underlying biophysical and mechanochemical processes, i...

journal_title：Bulletin of mathematical biology

authors： Coskun H,Coskun H

更新日期：2011-03-01 00:00:00

abstract：:A protein fold can be viewed as a self-avoiding walk in certain lattice model, and its contact map is a graph that represents the patterns of contacts in the fold. Goldman, Istrail, and Papadimitriou showed that a contact map in the 2D square lattice can be decomposed into at most two stacks and one queue. In the term...

journal_title：Bulletin of mathematical biology

authors： Guo QH,Sun LH,Wang J

更新日期：2017-01-01 00:00:00

abstract：:Although cell migration is an essential process in development, how cells reach their final destination is not well understood. Secreted molecules are known to have a migratory effect, but it remains unclear whether such molecules act as directional guidance cues or as motility regulators. There is potential to use si...

journal_title：Bulletin of mathematical biology

authors： Cai AQ,Landman KA,Hughes BD

更新日期：2006-01-01 00:00:00

abstract：:Advances in fluorescent labeling of cells as measured by flow cytometry have allowed for quantitative studies of proliferating populations of cells. The investigations (Luzyanina et al. in J. Math. Biol. 54:57-89, 2007; J. Math. Biol., 2009; Theor. Biol. Med. Model. 4:1-26, 2007) contain a mathematical model with fluo...

journal_title：Bulletin of mathematical biology

authors： Banks HT,Sutton KL,Thompson WC,Bocharov G,Roose D,Schenkel T,Meyerhans A

更新日期：2011-01-01 00:00:00

abstract：:In this paper we formulate a multi-patch multi-species model in which the per-capita emigration rate of one species depends on the density of some other species. We then focus on Turing instability to examine if and when this cross-emigration response has crucial effects. We find that the type of interaction matters g...

journal_title：Bulletin of mathematical biology

authors： Huang Y,Diekmann O

更新日期：2003-01-01 00:00:00