Proton spectroscopy of the brain in HIV infection: correlation with clinical, immunologic, and MR imaging findings.

Abstract:

:Abnormalities at cerebral proton spectroscopy occur in patients with the acquired immunodeficiency syndrome (AIDS). N-acetyl aspartate (NAA) is believed to be a neuronal marker, and neuronal loss is thought to underlie the human immunodeficiency virus (HIV)-associated cognitive/motor complex. The proton spectra in 103 HIV-seropositive patients and 23 control subjects were compared and correlated with clinical, immunologic, and radiologic measures of HIV infection. Significant (P < .05) reductions in the mean NAA/choline (Cho) and NAA/creatine (Cr) ratios were seen in patients with immune suppression and neurologic signs. Significant increases in the Cho/Cr ratios were seen in patients with low CD4 lymphocyte counts and abnormal magnetic resonance (MR) images. Reduced NAA ratios correlated with diffuse but not focal MR imaging abnormalities. Combined MR imaging and spectroscopy provides closer relationships to clinical and immunologic measures of disease than either modality alone. Spectroscopy is an adjunct to MR imaging and augments the value of an MR imaging study.

journal_name

Radiology

journal_title

Radiology

authors

Chong WK,Sweeney B,Wilkinson ID,Paley M,Hall-Craggs MA,Kendall BE,Shepard JK,Beecham M,Miller RF,Weller IV

doi

10.1148/radiology.188.1.8099750

subject

Has Abstract,Author List Incomplete

pub_date

1993-07-01 00:00:00

pages

119-24

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

188

pub_type

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