Abstract：
:The aim of the study was to investigate the effect of a new selective alpha 1-adrenoreceptor blocker doxazosin on blood pressure, serum lipids and lipoproteins in patients with essential hypertension. The study was done in 32 out-patients with mild-to-moderate hypertension (22 men and 10 women, mean age 45.6 +/- 10.1). After 2-week placebo period the patients were given doxazosin in increasing doses from 1 to 8 mg daily for 6 to 14 weeks (mean daily dose 2.24 +/- 1.6 mg). Twenty-nine patients completed the study. The active treatment caused highly significant drop in systolic and diastolic blood pressure both in supine and standing positions. No orthostatic hypertension was noted. There was also a statistically significant decrease in serum total cholesterol, VLDL-cholesterol, and triglyceride levels and increase in the positive prognostic lipid indicators. HDL3-cholesterol and apolipoprotein AI levels as well as HDL/total cholesterol ratio. Accordingly, the statistically significant decrease of the so called atherogenic index was noted. The drug was well tolerated and only one patient dropped from the study because of side effects. The authors conclude that doxazosin appears to be an effective and well tolerated antihypertensive drug with a favorable effect on lipid metabolism. It may be particularly useful in hypertensive patients with coexisting lipid abnormalities.
journal_name
Kardiol Poljournal_title
Kardiologia polskaauthors
Sznajderman M,Chotkowska E,Peczkowska M,Sawicki M,Janaszek-Sitkowska H,Wiernikowska-Wegorek I,Galewicz A,Cybulska Isubject
Has Abstractpub_date
1993-02-01 00:00:00pages
107-11issue
2eissn
0022-9032issn
1897-4279journal_volume
38pub_type
杂志文章abstract：BACKGROUND:Patent foramen ovale (PFO) is a potential risk factor for ischaemic stroke in young individuals. An interventional method of secondary stroke prevention in PFO patients is its percutaneous closure. AIM:To assess safety and effectiveness (i.e. lack of residual shunt) of percutaneous PFO closure in patients w...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:We describe a case of a 59-year-old female with paroxysmal atrial fibrillation and arterial hypertension who had syncopal attacks due to polymorphic ventricular tachycardia (PMVT) with a short coupling interval of an initiating beat (280 msec). We excluded structural heart disease. In the resting ECG the QTc interval ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Optimisation of atrioventricular (AV) delay time has positive effects on left ventricular (LV) functions in patients with a DDD pacemaker. However, the method used for optimisation is still debated. AIM:To evaluate the effect of different AV delay times on various LV systolic performances by using automated...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2014.0045
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Although increased left atrial size (LA) has been long regarded as one of the factors negatively influencing the long-term maintenance of sinus rhythm (SR) following cardioversion (CV) of atrial fibrillation (AF), some reports suggested that CV might be effective also in patients with large LA.Aim. We sought...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2005-05-01 00:00:00
abstract：BACKGROUND AND AIM:To evaluate myocardial function with the use of tissue Doppler echocardiography in children with primary hypertension. METHODS:A total of 64 subjects (34 with hypertension, 30 control) underwent echocardiographic evaluation of systolic and diastolic function with the use of standard and tissue Doppl...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2014.0189
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Anthracycline affects various cell lines, which may contribute to left ventricular (LV) dysfunction and vascular remodelling. AIM:To assess the complex influence of anthracycline chemotherapy on the echocardiographic parameters of LV systolic and diastolic function and indices of vascular function and struc...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.2013.0154
更新日期：2013-01-01 00:00:00
abstract：:A case of recurrent severe mitral regurgitation following blunt chest trauma with deceleration injury in a 61-year-old woman is presented. The patient had undergone previous CABG and mitral annuloplasty with the use of a flexible (Duran) ring. At reoperation, partial dehiscence of the annuloplasty ring, which had beco...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：:In the face known antihypertensive action of small dopamine (DA) concentrations, serum free and conjugated dopamine levels were determined during orthostatic impulse. It was also estimated, whether correlation between blood pressure changes and serum dopamine concentration existed under those conditions. 9 patients wi...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：1990-02-01 00:00:00
abstract：BACKGROUND:Nesfatin-1 is a novel anorectic neuropeptide with potent metabolic regulatory effects. AIM:We aimed to evaluate the relationship between nesfatin-1 levels and slow coronary flow (SCF). METHODS:A total of 60 consecutive patients with SCF and 60 consecutive patients with normal coronary flow (NCF) were enrol...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2017.0210
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:The aetiology of contrast-induced acute kidney injury (CI-AKI) is not well understood. We hypothesised that the pathophysiology of CI-AKI and impaired coronary reperfusion (IR), observed after invasive treatment of acute myocardial infarction (AMI), could be similar and might be related to platelet count (PC...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2015.0054
更新日期：2015-01-01 00:00:00
abstract：:From the physiological point of view, carotid bodies are mainly responsible for the ventilatory response to hypoxia; however, they also take part in the regulation of sympathetic tone. According to preclinical data, these structures likely contribute to the development and progression of sympathetically mediated disea...
journal_title：Kardiologia polska
pub_type： 杂志文章,评审
doi：10.5603/KP.a2018.0178
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Differences in clinical manifestation, therapeutic strategies and prognosis in men and women with acute coronary syndromes became crucial in the last decade. AIM:To present clinical characteristics of Polish women with ST-segment elevation myocardial infarction (STEMI). METHODS:A total of 26,035 patients w...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：:119 hypertensive patients were examined by 24-hour ambulatory blood pressure monitoring (ABPM) and traditional (casual) blood pressure measurements. The echocardiographic examination was also performed. Mean and maximal systolic and diastolic blood pressure values, systolic and diastolic pressure amplitude as well as ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:Congenital abnormalities of the coronary arteries are found in 0.6-1.5% of patients in coronary angiographies and most of them are benign. Their presence may prolong the time of the examination which is important especially in patients with acute coronary syndromes (ACS). The incidence of coronary artery anomaly with ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.2013.0106
更新日期：2013-01-01 00:00:00
abstract：:Slow ventricular tachycardia (VT), which is below the detection rate of implantable cardioverter-defibrillator may cause haemodynamical instability, when pharmacological agents or antitachycardia pacing are unsuccessful, electrical cardioversion is necessary. We present another method of termination of slow VT by ICD,...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
abstract：:We are presenting the case of a 74 year-old female who was hospitalised twice within 6 months with acute coronary syndrome (ACS) and on both occasions was treated with coronary stenting. Both ACS were caused by an angiographically single vessel disease which occurred in different arteries (1(st) - left anterior descen...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Ventricular premature beats (VPBs) are one of the most common rhythm abnormalities. Structural heart diseases such as myocardial hypertrophy and left ventricular dysfunction are associated with VPBs. However, the exact mechanism of VPBs in patients without structural heart disease has not been revealed yet. ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2015.0025
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:The Ministry of Health in Poland recommends electrocardiogram (ECG)-based cardiovascular screening in athletes, but so far there has been a lack of guidelines on preparticipation assessment. We compared different criteria of ECG screening assessment in a group of top-level athletes. AIM:The aims were to eva...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2017.0021
更新日期：2017-01-01 00:00:00
abstract：:According to current guidelines surgical revascularisation is a gold standard of treatment in patients with multivessel and left main coronary disease. Hybrid revascularisation, in two stages: first - minimally invasive direct coronary artery bypass grafting procedure with left internal mammary artery conduit to left ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Severe cardiovascular complications are among the most important causes of mortality in systemic lupus erythematosus (SLE) patients. AIM:To assess the usefulness of echocardiography, ECG, and coronary artery calcium scoring (CACS) in the detection of myocardial ischaemia in SLE patients compared to single p...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Hypertension is more common after menopause. Increased incidence of hypertension can be attributed to autonomic nervous system dysfunction. The relationship between the parameters of heart rate variability (HRV), the levels of norepinephrine (NE) and leptin, and the menopausal status is still poorly understo...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Data on the results of ablation for atrial fibrillation (AF) in Poland are scarce. AIMS:The aim of the study was to compare the efficacy of ablation index (AI)-guided pulmonary vein isolation (PVI) with that of conventional contact force-based PVI. METHODS:Consecutive patients undergoing PVI for the first ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.33963/KP.15523
更新日期：2020-10-23 00:00:00
abstract：:Percutaneous intervention in saphenous vein grafts is associated with a high risk of distal embolisation by plaque material, 'no flow' phenomenon and clinical complications such as myocardial infarction or death. According to randomised trial evidence, intervention in a degenerated vein graft should be performed using...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2010-12-01 00:00:00
abstract：:Stent fracture (SF) has been suggested to be an unusual cause of restenosis after drug eluting-stent implantation. However, angiographically visible SF after bare metal stent (BMS) implantation is extremely rare. We present a case of a 58 year-old male patient who presented with unstable angina secondary to a SF of a ...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Platelets play a key role in the development and progression of cardiovascular disease. The degree of platelet activation may be assessed by platelet indices such as platelet count, mean platelet volume (MPV) and platelet distribution width (PDW). AIM:To evaluate the relationship between platelet indices an...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.2013.0293
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND AND AIM:In patients with mitral stenosis (MS) percutaneous mitral balloon valvuloplasty (PMBV) is used to im-prove symptoms and prognosis. Although there is some evidence for potential long-term benefits from PMBV in asymptomatic patients with mitral valve area (MVA) between 1.0 and 1.5 cm2, there are no fol...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2018.0036
更新日期：2018-01-01 00:00:00
abstract：:Two cases of coronary artery fistulas diagnosed during coronary angiography are reported and symptomatology of this disease is discussed. The first described patient suffered mainly from chest pain and dyspnoe, the second - from paroxysmal atrial fibrillation. Indications for pharmacological and surgical treatment are...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:Heart failure affects patients with normal left ventricular systolic function (heart failure with preserved ejection fraction [HFPEF]) and those with reduced ejection fraction (HFREF). The treatment of HFPEF remains an unresolved issue. AIM:We sought to determinate the relationship between inflammatory mark...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2018.0214
更新日期：2019-01-01 00:00:00
abstract：:Considerable variation in the use and duration of antiplatelet medications during the perioperative and postoperative care of patients undergoing coronary artery bypass grafting (CABG) reflects the limited number of studies focused directly on these patients as well as the variation in the results reported. In this re...
journal_title：Kardiologia polska
pub_type： 杂志文章,评审
doi：10.5603/KP.a2018.0111
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Clinical evaluation of patients with diabetes or after myocardial infarction (MI) with preserved left ventricular (LV) systolic function is not very precise in isolating patients at particularly high risk of developing manifest cardiac failure and associated cardiovascular incident. Early diagnosis of LV dia...
journal_title：Kardiologia polska
pub_type： 杂志文章
doi：10.5603/KP.a2015.0216
更新日期：2016-01-01 00:00:00
