Human carotid bodies as a therapeutic target: new insights from a clinician's perspective.

Abstract:

:From the physiological point of view, carotid bodies are mainly responsible for the ventilatory response to hypoxia; however, they also take part in the regulation of sympathetic tone. According to preclinical data, these structures likely contribute to the development and progression of sympathetically mediated diseases. Moreover, carotid body deactivation in animal models improved blood pressure control in hypertension and reduced mortality in heart failure, along with reducing sympathetic activity. On this basis, two first-in-man studies have been recently performed to investigate the safety and feasibility of such an approach in humans. In this review we summarise the current knowledge regarding the function of carotid bodies, the prevalence of their abnormalities, and the consequences of their excision in human hypertension and heart failure.

journal_name

Kardiol Pol

journal_title

Kardiologia polska

authors

Tubek S,Niewiński P,Paleczny B,Langner A,Banasiak W,Ponikowski P

doi

10.5603/KP.a2018.0178

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

1426-1433

issue

10

eissn

0022-9032

issn

1897-4279

pii

VM/OJS/KP/12474

journal_volume

76

pub_type

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