Abstract:
BACKGROUND:Anthracycline affects various cell lines, which may contribute to left ventricular (LV) dysfunction and vascular remodelling. AIM:To assess the complex influence of anthracycline chemotherapy on the echocardiographic parameters of LV systolic and diastolic function and indices of vascular function and structure. METHODS:35 women (age 50 ± 9 years old) with breast cancer scheduled for standard anthracycline chemotherapy were enrolled into the study. Examinations were performed at the baseline and six months after the last dose of anthracycline with a clinical follow-up of 9-12 months. LV systolic and diastolic function were assessed by: ejection fraction, transmitral flow, isovolumetric relaxation time, Tei index, mitral ring movement velocity and E/E' ratio. Vascular parameters, including flow-mediated dilatation, intima-media thickness (IMT), aortic compliance, common carotid artery (CCA) compliance, and stiffness indices b were measured. RESULTS:None of the patients revealed any cardiovascular symptoms during follow-up. LV systolic function parameters remained normal. However, LV end-diastolic diameter (46 ± 3.5 vs. 48 ± 4 mm, p = 0.004) and LV end-diastolic volume (101 ± 25 vs. 112 ± 26 mL, p = 0.01) increased. The diastolic function changed - the Tei index increased (0.49 ± 0.09 vs. 0.54 ± 0.1, p = 0.04) and E' (p = 0.049), A' (p = 0.02) and S (p = 0.01) decreased. The E/E' index increased (p < 0.0001) within the LV lateral wall. We observed an increase in carotid IMT (p < 0.0001), a decrease in aortic compliance (p = 0.042) and CCA compliance (p = 0.004), and an increase in aorta as well as the CCA stiffness indices (p = 0.046, p = 0.003, respectively). CONCLUSIONS:Standard-dose anthracycline chemotherapy is associated with LV dilatation and diastolic dysfunction, regardless of the preserved global systolic function. It coexists with negative structural arterial remodelling.
journal_name
Kardiol Poljournal_title
Kardiologia polskaauthors
Mizia-Stec K,Gościńska A,Mizia M,Haberka M,Chmiel A,Poborski W,Gąsior Zdoi
10.5603/KP.2013.0154subject
Has Abstractpub_date
2013-01-01 00:00:00pages
681-90issue
7eissn
0022-9032issn
1897-4279pii
VM/OJS/KP/8078journal_volume
71pub_type
杂志文章abstract::24 endomyocardial biopsies were performed in children aged 4-18 (x = 12.9) without any complications. The endomyocardial biopsy was performed in 12 patients with the heart failure of unknown origin (6 - restrictive heart disease, 4 - dilated cardiomyopathy with arrhythmias, 2-post-inflammatory dilated cardiomyopathy),...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Patient with stable ischaemic heart disease and essential thrombocythemia in Invasive Cardiology Laboratory -- role of the automated systems for estimation of platelet aggregation. A case of a 63-year-old male patient with essential thrombocythemia and coronary artery disease is presented. The patient underwent electi...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
abstract::In 3 post-MI patients with multiple premature ventricular complexes, programmed transoesophageal pacing generated the arrhythmia and an ecg tracing was taken. Analysis of the ecg suggested that simultaneous activation of two pathways within the A-V node maybe the cause of the arrhythmia. The activation signal reaches ...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::An 8.5-year-old girl evaluated for central cyanosis, hypoxia and normocarbia was found to have aorticopulmonary window and pulmonary hypertension. The diagnosis of Eisenmenger syndrome (ES) was made and treatment with bosentan was started. Four months later she was diagnosed to have juvenile rheumatoid arthritis and n...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2009-12-01 00:00:00
abstract::Twenty-five years after the first publication of the strong natriuretic effect of rat cardiac atria extract, natriuretic peptides play an important part in everyday, not only cardiological, practice. In the current review the authors briefly describe the role of natriuretic peptides (ANP, BNP, and CNP) in clinical pra...
journal_title:Kardiologia polska
pub_type: 杂志文章,评审
doi:
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Sotalol is a class III antiarrhythmic drug commonly used in various arrhythmia treatments. However, due to its potent potassium channel inhibition, it can prolong the QT interval and lead to malignant arrhythmias. Empagliflozin is an inhibitor of sodium‑glucose cotransporter 2 (SGLT2) and has a positive effe...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.33963/KP.15666
更新日期:2021-01-25 00:00:00
abstract:BACKGROUND:Cardiovascular diseases (CVDs) are the main cause of morbidity and mortality in developed countries. Despite the progress in diagnostics and treatment, it is expected that CVD will still be the main cause of death worldwide until at least 2030. From 1991 CVD mortality in Poland systematically decreased, but ...
journal_title:Kardiologia polska
pub_type: 杂志文章,多中心研究
doi:10.5603/KP.a2015.0235
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:It is commonly believed that women undergoing isolated coronary artery bypass graft surgery (CABG) are subject to a higher risk of perioperative complications and death. AIM:To evaluate the effect of sex as a risk factor on early complications and mortality after isolated CABG performed with cardiopulmonary...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.5603/KP.a2014.0166
更新日期:2015-01-01 00:00:00
abstract::In the face known antihypertensive action of small dopamine (DA) concentrations, serum free and conjugated dopamine levels were determined during orthostatic impulse. It was also estimated, whether correlation between blood pressure changes and serum dopamine concentration existed under those conditions. 9 patients wi...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00
abstract::A 25-year-old woman, gravida 2, para 1, without any previous medical history was admitted to the hospital because of the signs and symptoms of fetal distress. After a caesarean section the woman developed an acute heart failure. Echocardiography demonstrated massive vegetations attached to aortic and mitral valves wit...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Primary aldosteronism is one of the most common causes of secondary hypertension. Adrenal vein sampling (AVS) remains a "gold standard" procedure in differentiation between unilateral (adenoma) and bilateral (hyperplasia) disease. AIM:The aim of this study was to present our single-centre experience in esta...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.5603/KP.a2016.0166
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND AIM:To assess the safety and efficacy of a refined balloon pulmonary angioplasty (BPA) strategy in patients with chronic thromboembolic pulmonary hypertension (CTEPH). METHODS:There were 157 BPA sessions performed in 56 CTEPH patients (47 non-operable, nine after pulmonary endarterectomy; aged 58.6 ± 17...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.5603/KP.a2017.0091
更新日期:2017-01-01 00:00:00
abstract::In 75 patients 24-hour ecg monitoring value was compared with exercise test in diagnostics of postinfarction silent ischemia. Results compatibility of both comparing examinations was 79% with regard to only painless ischemia (p less than 0.001) and 91% to both estimated painless or painful episodes (p less than 0.001)...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:An individual assessment of global risk of death from cardiovascular diseases (CVD) should guide management, both life style changes and medical therapy, in order to decrease risk factors and improve prognosis. AIM:We assessed global risk in the Polish population and its relation to medical care, including ...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Permanent atrial fibrillation (AF) is present before operation and persists after surgery in 30-40% of patients undergoing mitral valve surgery. Using the maze procedure, 75-82% of patients can be cured of AF, but the procedure is difficult and long lasting. Percutaneous radiofrequency (RF) ablation has emer...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract::Endothelin is a family of potent vasoconstrictor peptides of vascular endothelial origin. Although it has been proposed that the vasoconstrictor effects of endothelin are produced at the local vascular level, the current study was performed to test the hypothesis that plasma endothelin concentrations are elevated in p...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Patent foramen ovale (PFO) is a potential risk factor for ischaemic stroke in young individuals. An interventional method of secondary stroke prevention in PFO patients is its percutaneous closure. AIM:To assess safety and effectiveness (i.e. lack of residual shunt) of percutaneous PFO closure in patients w...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Progress in non-invasive diagnostic techniques such as ultrasonography, computerised tomography or magnetic resonance caused a significant decrease in the use of diagnostic myocardial biopsy (DMB). However, recent advances in molecular biology and widening knowledge about the role of new biochemical markers ...
journal_title:Kardiologia polska
pub_type: 历史文章,杂志文章
doi:
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is the most common arrhythmia, having a strong impact on long-term stroke and heart failure prevalence and mortality. Nowadays, rapid development in the field of minimising the invasiveness of surgical ablation of AF can be observed. AIM:To report on the feasibility and early result...
journal_title:Kardiologia polska
pub_type: 临床试验,杂志文章
doi:
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:The growing penetration of mechanical reperfusion in ST-elevation myocardial infarction (STEMI) has been achieved by the creation of new percutaneous coronary intervention (PCI) centres which have helped to shorten delays but have compromised PCI volumes. AIM:To compare the outcomes in STEMI patients treate...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.5603/KP.a2014.0131
更新日期:2014-01-01 00:00:00
abstract::A case of a 66-year-old male with acute myocardial infarction (MI) treated with streptokinase is presented. Due to the recurrence of angina six days from the acute phase of MI, the patient underwent coronary angiography which revealed critical stenosis of the left anterior descending coronary artery. During intracoron...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
abstract::Cardiopulmonary exercise testing (CPET) is an important diagnostic tool in contemporary clinical practice. This document presents an expert opinion from the Working Group on Cardiac Rehabilitation and Exercise Physiology of the Polish Cardiac Society concerning the indications, performance technique, and interpretatio...
journal_title:Kardiologia polska
pub_type: 杂志文章,实务指引
doi:10.33963/KP.14889
更新日期:2019-08-23 00:00:00
abstract:BACKGROUND:Due to the recent rapid increase in the number of patients implanted with pacemakers, cardioverter-defibrillators (ICD), and cardiac resynchronisation therapy devices (CRT), conventional monitoring at specialist clinics is becoming increasingly difficult. The development of technology has enabled remote devi...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.5603/KP.a2016.0019
更新日期:2016-01-01 00:00:00
abstract::We present a patient at risk of sudden cardiac death in whom ventricular fibrillation was effectively treated by wearable automatic defibrillator. We discuss the technical aspects of the device, current indications for this therapy and outcomes. ...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Carotid artery stenting (CAS) has become an alternative for carotid endarterectomy in the treatment of carotid artery atherosclerosis, due to limited injury and comparable periprocedural risk. The impact of coronary artery disease (CAD) on long-term follow-up after CAS needs to be reconsidered due to the int...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.5603/KP.a2014.0217
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Differences between men and women in the prevalence and clinical course of coronary artery disease (CAD) have been well documented. There are no data in literature on the differences between males and females in the incidence of post-infarction left ventricular (LV) wall motion abnormalities of akinesia/dysk...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Aborted myocardial infarction (abMI) is a type of acute coronary syndrome in which patients treated with reperfusion avoid the great burden of necrosis. Yet, no definition of abMI in patients undergoing primary percutaneous coronary intervention (pPCI) has been proposed so far. AIMS:This study aimed to iden...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.33963/KP.15650
更新日期:2021-01-25 00:00:00
abstract:BACKGROUND:Patients with advanced lower limb ischaemia are, at present, mainly treated using revascularisation. AIM:The aim of the study was to investigate whether the dynamics of blood flow in below-the-knee (BTK) arteries assessed by angiography correlate with clinical outcomes after a 12-month follow-up in patients...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.5603/KP.a2018.0212
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Nesfatin-1 is a novel anorectic neuropeptide with potent metabolic regulatory effects. AIM:We aimed to evaluate the relationship between nesfatin-1 levels and slow coronary flow (SCF). METHODS:A total of 60 consecutive patients with SCF and 60 consecutive patients with normal coronary flow (NCF) were enrol...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.5603/KP.a2017.0210
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Despite the increasing number of patients after percutaneous coronary intervention (PCI) requiring coronary artery bypass grafting (CABG), studies on the impact of these procedures on surgical revascularisation outcomes are sparse. Furthermore, advances in cardiology require reassessment of their potential p...
journal_title:Kardiologia polska
pub_type: 杂志文章
doi:10.5603/KP.a2018.0039
更新日期:2018-01-01 00:00:00