Abstract:
:Tropheryma whipplei endocarditis differs from classic Whipple disease, which primarily affects the gastrointestinal system. We diagnosed 28 cases of T. whipplei endocarditis in Marseille, France, and compared them with cases reported in the literature. Specimens were analyzed mostly by molecular and histologic techniques. Duke criteria were ineffective for diagnosis before heart valve analysis. The disease occurred in men 40-80 years of age, of whom 21 (75%) had arthralgia (75%); 9 (32%) had valvular disease and 11 (39%) had fever. Clinical manifestations were predominantly cardiologic. Treatment with doxycycline and hydroxychloroquine for at least 12 months was successful. The cases we diagnosed differed from those reported from Germany, in which arthralgias were less common and previous valve lesions more common. A strong geographic specificity for this disease is found mainly in eastern-central France, Switzerland, and Germany. T. whipplei endocarditis is an emerging clinical entity observed in middle-aged and older men with arthralgia.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Fenollar F,Célard M,Lagier JC,Lepidi H,Fournier PE,Raoult Ddoi
10.3201/eid1911.121356subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1721-30issue
11eissn
1080-6040issn
1080-6059journal_volume
19pub_type
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