Tropheryma whipplei endocarditis.

Abstract:

:Tropheryma whipplei endocarditis differs from classic Whipple disease, which primarily affects the gastrointestinal system. We diagnosed 28 cases of T. whipplei endocarditis in Marseille, France, and compared them with cases reported in the literature. Specimens were analyzed mostly by molecular and histologic techniques. Duke criteria were ineffective for diagnosis before heart valve analysis. The disease occurred in men 40-80 years of age, of whom 21 (75%) had arthralgia (75%); 9 (32%) had valvular disease and 11 (39%) had fever. Clinical manifestations were predominantly cardiologic. Treatment with doxycycline and hydroxychloroquine for at least 12 months was successful. The cases we diagnosed differed from those reported from Germany, in which arthralgias were less common and previous valve lesions more common. A strong geographic specificity for this disease is found mainly in eastern-central France, Switzerland, and Germany. T. whipplei endocarditis is an emerging clinical entity observed in middle-aged and older men with arthralgia.

journal_name

Emerg Infect Dis

authors

Fenollar F,Célard M,Lagier JC,Lepidi H,Fournier PE,Raoult D

doi

10.3201/eid1911.121356

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1721-30

issue

11

eissn

1080-6040

issn

1080-6059

journal_volume

19

pub_type

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