IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

Abstract:

:We investigated the dynamics of seroconversion in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During March 29-May 22, 2020, we collected serum samples and associated clinical data from 177 persons in London, UK, who had SARS-CoV-2 infection. We measured IgG against SARS-CoV-2 and compared antibody levels with patient outcomes, demographic information, and laboratory characteristics. We found that 2.0%-8.5% of persons did not seroconvert 3-6 weeks after infection. Persons who seroconverted were older, were more likely to have concurrent conditions, and had higher levels of inflammatory markers. Non-White persons had higher antibody concentrations than those who identified as White; these concentrations did not decline during follow-up. Serologic assay results correlated with disease outcome, race, and other risk factors for severe SARS-CoV-2 infection. Serologic assays can be used in surveillance to clarify the duration and protective nature of humoral responses to SARS-CoV-2 infection.

journal_name

Emerg Infect Dis

authors

Staines HM,Kirwan DE,Clark DJ,Adams ER,Augustin Y,Byrne RL,Cocozza M,Cubas-Atienzar AI,Cuevas LE,Cusinato M,Davies BMO,Davis M,Davis P,Duvoix A,Eckersley NM,Forton D,Fraser AJ,Garrod G,Hadcocks L,Hu Q,Johnson M,

doi

10.3201/eid2701.203074

subject

Has Abstract

pub_date

2021-01-01 00:00:00

issue

1

eissn

1080-6040

issn

1080-6059

journal_volume

27

pub_type

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