Abstract:
:The permeation enhancing property of 5% oleic acid in ethanol on beta-estradiol was investigated in vitro and in vivo using symmetrical and asymmetrical side-by-side diffusion cells and the human skin sandwich flap, respectively. beta-Estradiol permeability in vitro and in vivo was similar in 75% ethanol (ETOH). Oleic acid (5%) did not alter beta-estradiol permeability in vivo but increased permeability six-fold in vitro in symmetrical diffusion cells. beta-Estradiol permeability in oleic acid was not different from that in ETOH, however, using asymmetrical diffusion cells. Stratum corneum-to-vehicle partition coefficients of beta-estradiol in the vehicles were similar, yet fourfold more steroid was detected in skin biopsies from the in vitro symmetrical diffusion cells. Thus, oleic acid increased beta-estradiol permeability in vitro only when skin was equilibrated with fatty acid. Attention to in vitro diffusion cell design and its relevance in vivo is critical to defining the mechanisms of enhanced solute permeation.
journal_name
Pharm Resjournal_title
Pharmaceutical researchauthors
Pershing LK,Parry GE,Lambert LDdoi
10.1023/a:1018974131236subject
Has Abstractpub_date
1993-12-01 00:00:00pages
1745-50issue
12eissn
0724-8741issn
1573-904Xjournal_volume
10pub_type
杂志文章abstract::Many drugs and desirable phytochemicals are bitter, and bitter tastes are aversive. Food and pharmaceutical manufacturers share a common need for bitterness-masking strategies that allow them to deliver useful quantities of the active compounds in an acceptable form and in this review we compare and contrast the chall...
journal_title:Pharmaceutical research
pub_type: 杂志文章,评审
doi:10.1007/s11095-014-1480-6
更新日期:2014-11-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章,随机对照试验
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更新日期:2005-04-01 00:00:00
abstract::Knowledge Management (KM) is a key enabler for achieving quality in a lifecycle approach for production of biopharmaceuticals. Due to the important role that it plays towards successful implementation of Quality by Design (QbD), an analysis of KM solutions is needed. This work provides a comprehensive review of the in...
journal_title:Pharmaceutical research
pub_type: 杂志文章,评审
doi:10.1007/s11095-016-2043-9
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:Lapatinib, a small molecule EGFR/HER2 inhibitor, partially inhibits the outgrowth of HER2+ brain metastases in preclinical models and in a subset of CNS lesions in clinical trials of HER2+ breast cancer. We investigated the ability of lapatinib to reach therapeutic concentrations in the CNS following (14)C-lapa...
journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1007/s11095-011-0601-8
更新日期:2012-03-01 00:00:00
abstract::A reverse-phase HPLC method for the analysis of tryptic digests of recombinant porcine growth hormone (pGH) has been developed and validated. Digestion was performed at 4 degrees C for a 20-hr period with TPCK-treated trypsin at a 1:20 (w/w) trypsin:pGH ratio. Gradient elution HPLC, using an Aquapore RP300 C8 column, ...
journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1018927426268
更新日期:1993-10-01 00:00:00
abstract:PURPOSE:The prognosis for glioma patients is poor, and development of new treatments is critical. Previously, we engineered polymer-based vaccines that control GM-CSF, CpG-oligonucleotide, and tumor-lysate presentation to regulate immune cell trafficking and activation, which promoted potent immune responses against pe...
journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1007/s11095-010-0361-x
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:We present a smart intradermal interface suitable for skin-attached drug delivery devices. Our solution enables injections or infusions that are less invasive compared to subcutaneous injections and are leakage-free at the location of penetration. METHODS:The intradermal interface is based on a 31-gauge cannul...
journal_title:Pharmaceutical research
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更新日期:2011-03-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1015973425708
更新日期:1988-08-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2004-08-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2016-01-01 00:00:00
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更新日期:2018-07-30 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2003-08-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-03-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1018918022865
更新日期:1994-11-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:2018-05-22 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1014212630566
更新日期:2002-02-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
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更新日期:1997-12-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2011-05-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2017-12-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:1995-05-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1011914618109
更新日期:1998-02-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1016479305603
更新日期:1987-04-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:2002-06-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:1992-02-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1015841715384
更新日期:1991-06-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:1996-11-01 00:00:00