Abstract：
PURPOSE:We present a smart intradermal interface suitable for skin-attached drug delivery devices. Our solution enables injections or infusions that are less invasive compared to subcutaneous injections and are leakage-free at the location of penetration. METHODS:The intradermal interface is based on a 31-gauge cannula embedded in a slider, movable relative to a carrier plate that can easily be fixed onto the skin. By simply pushing the slider, the cannula is inserted into the dermis. RESULTS:We performed injections and infusions with stained water and polyethylene glycol (PEG) solution in ex vivo pig skin. The sizes of coloured spots in the skin range from 3.5 mm(2) to 15.4 mm(2) for stained water depending on the infused volume. Infusing stained PEG solution resulted in stained tissue areas about one order of magnitude larger. One of three investigated leakage modes is unacceptable but can be reliably avoided by proper site selection. At low flow rates and at the beginning of an infusion an initial back pressure overshoot was identified. This effect was identified as the limiting parameter for the design of small programmable or intelligent devices based on micro actuators. CONCLUSIONS:With the proposed easy-to-use interface, intradermal injections and infusions can be performed reliably. Therefore, it is supposed to be an ideal and clinically relevant solution for self-administration of parenteral drugs in home care applications.
journal_name
Pharm Resjournal_title
Pharmaceutical researchauthors
Vosseler M,Jugl M,Zengerle Rdoi
10.1007/s11095-010-0319-zsubject
Has Abstractpub_date
2011-03-01 00:00:00pages
647-61issue
3eissn
0724-8741issn
1573-904Xjournal_volume
28pub_type
杂志文章abstract：:During protein lyophilization, it is common practice to complete the freezing step as fast as possible in order to avoid protein denaturation, as well as to obtain a final product of uniform quality. We report a contradictory observation made during lyophilization of recombinant tissue-type plasminogen activator (t-PA...
journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1023/a:1016270103863
更新日期：1995-01-01 00:00:00
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journal_title：Pharmaceutical research
pub_type： 杂志文章
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journal_title：Pharmaceutical research
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doi：10.1007/s11095-016-2082-2
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journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1023/a:1018930718979
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journal_title：Pharmaceutical research
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doi：10.1023/a:1020492213172
更新日期：2002-10-01 00:00:00
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journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1023/a:1018946512445
更新日期：1994-09-01 00:00:00
abstract：:Determination of methadone (MET) in biological fluids can serve to adjust dosages in patients suffering from cancer pain or participating in methadone maintenance programs. We developed a gas chromatographic assay using nitrogen-phosphorus detection. The method involves a single-step extraction from alkalized plasma, ...
journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1023/a:1018904825958
更新日期：1993-03-01 00:00:00
abstract：PURPOSE:Bioadhesion is an important property of biological membranes, that can be utilized in pharmaceutical and biomedical applications. In this study, we have fabricated mucoadhesive drug releasing films with bio-based, non-toxic and biodegradable polymers that do not require chemical modifications. METHODS:Nanofibr...
journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1007/s11095-018-2428-z
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journal_title：Pharmaceutical research
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journal_title：Pharmaceutical research
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doi：10.1007/s11095-012-0932-0
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journal_title：Pharmaceutical research
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doi：10.1023/a:1018973530443
更新日期：1993-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11095-007-9490-2
更新日期：2008-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1023/b:pham.0000033007.27278.60
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journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1023/a:1015931105660
更新日期：1988-10-01 00:00:00
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journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1023/b:pham.0000003383.86238.d1
更新日期：2003-11-01 00:00:00
abstract：:The use of microdialysis sampling to study the binding of drugs to plasma proteins was evaluated. Microdialysis sampling is accomplished by placing a short length of dialysis fiber in the sample and perfusing the fiber with a vehicle. Small molecules in the sample, such as drugs, diffuse into the fiber and are transpo...
journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1023/a:1015955503708
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journal_title：Pharmaceutical research
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journal_title：Pharmaceutical research
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journal_title：Pharmaceutical research
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journal_title：Pharmaceutical research
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journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1007/s11095-012-0953-8
更新日期：2013-06-01 00:00:00
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journal_title：Pharmaceutical research
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doi：10.1023/a:1013042817281
更新日期：2001-11-01 00:00:00
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journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1023/a:1016002606705
更新日期：1996-07-01 00:00:00
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journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1023/a:1018910200420
更新日期：1999-11-01 00:00:00
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journal_title：Pharmaceutical research
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更新日期：1994-01-01 00:00:00
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journal_title：Pharmaceutical research
pub_type： 杂志文章
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更新日期：2021-01-15 00:00:00
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journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1023/a:1018887216098
更新日期：1999-01-01 00:00:00
abstract：PURPOSE:To investigate if gamma-Hydroxybutyrate (GHB) tolerance is mediated by alterations in GHB systemic pharmacokinetics, transport (blood brain barrier (BBB) and neuronal) or membrane fluidity. MATERIALS AND METHODS:GHB tolerance in rats was attained by repeated GHB administration (5.31 mmol/kg, s.c., QD for 5 day...
journal_title：Pharmaceutical research
pub_type： 杂志文章
doi：10.1007/s11095-006-9066-6
更新日期：2006-09-01 00:00:00
