Abstract:
:The inability to examine initiation and progression of periodontal disease and to assess certain therapies in humans has led to a great interest in the use of animal models in periodontal research. Some of the most prominent animals used are non-human primates. This article reviews the characteristics of non-human primate models in periodontal health, in the transition from health to gingivitis to periodontitis, and in experimental gingivitis and periodontitis. Where possible, the results of these studies are compared with results from human studies. Only a few studies have compared in detail the anatomy, physiology, immunology, and tissue interactions in monkeys with those of humans. With the exceptions of differences and variations in size of the dentition, the number of each tooth type as well as larger canines, presence of diastemata between anterior teeth, and an edge-to-edge relationship of the incisors, the dental and periodontal anatomy of non-human primates seem quite similar to that of humans. Clinically healthy gingiva can be established and maintained in non-human primates, and gingivitis as well as periodontitis occur in these animals. It is possible to induce experimental periodontitis by placement of peri-dental silk ligatures or orthodontic elastics as well as by surgical removal of alveolar bone. Although the most appropriate model for studies of periodontal disease pathogenesis in non-human primates appears to involve the application of silk ligatures, some difficulties may occur in establishing periodontal break-down by using this model. Many clinical, histological, microbiological, and immunological characteristics of spontaneous and experimental marginal inflammation in most non-human primates are similar to those in humans. The most significant differences between small non-human primates and humans are the very limited number of lymphocytes and plasma cells in the inflammatory infiltrate of squirrel monkeys (Saimiri sciureus) and marmosets. Therefore, the use of squirrel monkeys and marmosets may not be appropriate in many studies of periodontal disease pathogenesis. The most significant microbial differences between macaque species and humans are a lower proportion of Actinomyces species, the presence of a catalase-producing Prevotella melaninogenica strain, and the high carrier rate for Actinobacillus actinomycetemcomitans in subgingival plaque of macaque species. The significance of these differences is presently unknown. It is concluded that the use of many non-human primate species due to the apparent close anatomic and biologic similarities to humans is appropriate in experimental studies of periodontal disease, provided the use of laboratory animals is requisite and lower species are not applicable.(ABSTRACT TRUNCATED AT 400 WORDS)
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Schou S,Holmstrup P,Kornman KSdoi
10.1902/jop.1993.64.6.497subject
Has Abstractpub_date
1993-06-01 00:00:00pages
497-508issue
6eissn
0022-3492issn
1943-3670journal_volume
64pub_type
杂志文章,评审abstract::The aim of this investigation was to induce alveolar bone defects experimentally in dogs and to study the effects of mechanical tooth cleaning on their subsequent development. Thirty premolars from four beagle dogs were used. Bone defects were created by surgically exposing the adjacent alveolar bone and applying stee...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1978.49.3.135
更新日期:1978-03-01 00:00:00
abstract:BACKGROUND:Several studies have indicated a relationship between rheumatoid arthritis and periodontal disease. The aim of this study was to investigate the association between the circulating proinflammatory mediators tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta, prostaglandin E(2), serotonin, rheumatoid ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2008.070599
更新日期:2008-09-01 00:00:00
abstract::The inter-incisal distance and dimension of the interdental papilla between the mandibular incisors were examined in cyclosporin A (CSA) fed rats over 6 weeks. Rats in the test group received CSA daily in mineral oil by gastric feeding (30 mg/kg body weight); the control group received mineral oil only. The inter-inci...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1997.68.12.1231
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Gingival recession (GR) defects can be treated by various methods, including acellular dermal matrix (ADM) or coronally advanced flaps (CAFs). The aim of this histomorphometric experiment is to compare the efficacy of ADM and CAF for treating GR defects in dogs. METHODS:In eight beagle dogs, a critical-size...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2012.120380
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:The adjunctive use of enamel matrix derivative (EMD) in the surgical therapy of intrabony defects results in improved outcomes compared to surgical debridement alone. However, the role of EDTA root conditioning in EMD therapy has not been investigated. The purpose of this study was to compare the 12-month ou...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.77.1.103
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:To date only a few studies have evaluated the long-term influence of smoking and smoking cessation on periodontal health. The present study, therefore, was undertaken with the aim to prospectively investigate the influence of smoking exposure over time on the periodontal health condition in a targeted popula...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2000.71.8.1338
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:Porphyromonas gingivalis (Pg) is a major etiologic agent of periodontitis, whose virulence has been attributed to different factors, including lipopolysaccharide (LPS). Vascular ectopic calcification as a well-known major risk factor for adverse cardiovascular diseases is a highly prevalent vascular pathophe...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.150602
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:In a previous study, recombinant human transforming growth factor-beta1 (rhTGF-β1 ) in a calcium carbonate carrier was implanted into critical-size, supraalveolar periodontal defects under conditions for guided tissue regeneration (GTR) to study whether rhTGF-β1 would enhance or accelerate periodontal regene...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060336
更新日期:2007-04-01 00:00:00
abstract::The relation between utilization of dental services from community dentists and the extent and severity of alveolar bone loss is reported for a panel of men followed for over 6 years. Oral health data were collected by the Department of Veterans Affairs, Dental Longitudinal Study, which began in 1969 and still continu...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1994.65.5s.551
更新日期:1994-05-01 00:00:00
abstract::von Willebrand's disease (vWD) is one of the most common hereditary hemorrhagic disorders. A mild to moderate deficiency of factor VIII and von Willebrand factor (vWf) often is associated with gingival bleeding. In this case report, the periodontal treatment of a patient with vWD is described. A 45-year-old woman with...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.5.548
更新日期:1999-05-01 00:00:00
abstract::This review defines terms such as accuracy, validity, and reliability, which are used to describe the quality of methods for taking x-rays and for analyzing digital images. Values for these parameters are described for techniques of taking standardized x-rays such as ear-rod fixation and fixation by use of teeth with ...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2000.71.3.497
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:The purpose of this multicenter randomly controlled clinical trial was to compare two acellular dermal matrix (ADM) materials produced by different processing techniques, freeze-dried (FDADM) and solvent-dehydrated (SDADM) ADM, in their ability to correct Miller Class I and II recession defects. METHODS:Eig...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1902/jop.2014.140198
更新日期:2014-12-01 00:00:00
abstract::A scanning electron microscope and electron probe study was carried out to compare root structure from deep within periodontal pockets with roots exhibiting no periodontal disease. To eliminate the possibility of extraneous ion introduction or deletion, no attempt was made to subject the roots to fixation, embedding, ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.9.634
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:It has been shown that toll-like receptor (TLR) 2- and TLR4-stimulating abilities of supragingival plaque (SPP) are associated with periodontal conditions. It is hypothesized that SPP might affect the periodontium through its influence on subgingival plaque (SBP). This study investigates relationships betwee...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2016.150573
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated that bone demineralization can improve consolidation in bone grafts. The biologic mechanisms underlying this phenomenon remain unclear. METHODS:Twelve adult male guinea pigs were used in this experiment. Forty-five bone samples removed from the calvaria of nine animals wer...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.130657
更新日期:2015-01-01 00:00:00
abstract::A retrospective study of tooth loss in 211 patients who were treated for periodontal disease in private practice and maintained for 15 to 34 years on 3- to 6-month recall schedules is reported. The average age of the patients was 42 years, and the average length of time in maintenance was 22 years. On the basis of res...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.6.347
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:Alveolar ridge augmentation procedures are often needed prior to implant placement or prosthetic rehabilitation. The purpose of this study was to develop a quantitative method to assess the clinical outcome of such procedures. METHODS:Two volumetric methods, based on the volume difference between the pre- a...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2002.73.3.302
更新日期:2002-03-01 00:00:00
abstract::The effects of twice weekly topical applications of hydrogen peroxide on the buccal epithelium of Syrian hamsters were studied. Animals were treated either with hydrogen peroxide alone, with hydrogen peroxide and the carcinogen 9, 10-dimethyl-1,2-benzanthracene (DMBA), or with DMBA alone. In animals treated with 30% H...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.11.685
更新日期:1986-11-01 00:00:00
abstract::Oral malodor was measured using a portable sulphide monitor in 2,672 individuals aged 18 to 64 years. In addition, dental (DMFT) and periodontal conditions (CPITN and attachment loss), dental plaque, and tongue coating status were assessed. Before clinical examination, subjects were interviewed about their oral health...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1995.66.8.679
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Microbial internal contamination of oral implants has been suggested as being responsible for inflammatory infiltration of peri-implant tissues at the fixture-abutment interface of 2-stage and 2-component implant systems; it is also considered as a potential source of pathogens. The present in vivo study eva...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2001.72.12.1652
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Periodontitis and osteoporosis are characterized by the loss of bone mass. Osteocalcin levels have been postulated as a marker of inhibition of bone formation. The aim of the present study was to assess plasma, saliva, and gingival crevicular fluid (GCF) levels of osteocalcin and correlate them with periodon...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.4.513
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Chronic exposure to occupational noise is reported to cause a wide range of health problems. But, there are no reports on studies investigating the association between noise exposure and periodontitis. The purpose of this study was to examine the relationship between occupational noise exposure and periodont...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.17-0484
更新日期:2018-04-01 00:00:00
abstract::A technique designed to utilize the autogenous free gingival graft without the use of sutures was demonstrated. Necessary objectives were maintained but achieved without unnecessarily piercing the graft, and in less time. The only variance in results would be due to the underlying physical properties of the recipient ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1979.50.2.75
更新日期:1979-02-01 00:00:00
abstract:BACKGROUND:Systemic antibiotics are often used as adjunctive treatment modalities for periodontal diseases. Testing of antimicrobial efficacy can be relevant only if the bacteria are in the form of biofilms rather than the planktonic state, and at concentrations of physiologic relevance, i.e., reachable in the periodon...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2013.130167
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Pigmentations of the oral cavity are commonly noted in clinical practice and may have physiologic, non-physiologic, or pathologic etiologies. The most common non-physiologic localized pigmentation is the amalgam tattoo; another, less common, non-physiologic pigmentation is the graphite tattoo. Graphite tatto...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2005.76.9.1572
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:We used epidemiologic data of clinical periodontal status from two population-based samples in two countries, United States and Germany, to examine 1) the impact of age on the relative contribution of recession and pocketing on the distribution of clinical attachment loss, and 2) whether it is feasible to def...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.17-0670
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Earlier studies have shown an association between obesity and periodontitis, which is mediated by cytokine production. The aim of this study is to assess the role of obesity as a modifying factor on periodontal clinical parameters and on circulating proinflammatory cytokine levels in subjects undergoing non-...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2010.100545
更新日期:2011-05-01 00:00:00
abstract::A National Survey of the Oral Health of U.S. children aged 5 to 17 was conducted by the National Institute of Dental Research during the 1986-87 school year. Eleven thousand and seven adolescents aged 14 to 17 years received a periodontal assessment. Their patterns of loss of periodontal attachment as assessed by prob...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1991.62.10.608
更新日期:1991-10-01 00:00:00
abstract::This study clinically analyzed the efficacy of a connective tissue graft including the periosteum used as a barrier to enhance new attachment and osseous regeneration. Fifteen patients, with no systemic diseases, and adult periodontitis including 2 Class II furcation involvements in lower molars comprised the study gr...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.1991.62.12.775
更新日期:1991-12-01 00:00:00
abstract::Extracts of corn and some nuts were found to ubiquitously stimulate both adult and newborn cord blood lymphocytes to transform and produce a factor chemotactic for monocytes. This indicates that corn and nuts contain a mitogen and are potential stimulators of the cellular immune response. The exposure of lymphocytes t...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.9.562
更新日期:1975-09-01 00:00:00