A multiphase system bone implant for regenerating the calvaria.

Abstract:

:The regeneration of bone with a biodegradable, biocompatible carrier and osteo-regenerative proteins may be possible if the carrier has the appropriate architecture to support osteoconduction and prevent soft-tissue prolapse into ablated bone segments. Using radiomorphometry and histomorphometry, our group assessed individually and combined the components of a multiphase system bone implant (MSI) in rabbit cranial defects (critical-size defects: CSDs): two disks of biodegradable polymer (PLG) and demineralized bone matrix (DBM), a recognized osteo-regenerative material. We used 48 rabbits evenly divided between four treatment groups and two time periods. Six weeks after treatment, both DBM and PLG had significant positive effects on bone regeneration (based on a three-factor analysis of variance, p < 0.05). These effects were synergistic when the components were combined (MSI). Defects treated with DBM or PLG alone continued to regenerate bone through 12 weeks. By this time, bone within the defects treated with MSI appeared to be maturing and consolidating. We conclude that the concept of placing osteo-regenerative factors between two biodegradable disks for regenerating segments of calvaria is viable.

journal_name

Plast Reconstr Surg

authors

Kleinschmidt JC,Marden LJ,Kent D,Quigley N,Hollinger JO

doi

10.1097/00006534-199304000-00002

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

581-8

issue

4

eissn

0032-1052

issn

1529-4242

journal_volume

91

pub_type

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