Abstract:
OBJECTIVE:Connect-Four, a new sensorimotor rhythm (SMR) based brain-computer interface (BCI) gaming application, was evaluated by four severely motor restricted end-users; two were in the locked-in state and had unreliable eye-movement. METHODS:Following the user-centred approach, usability of the BCI prototype was evaluated in terms of effectiveness (accuracy), efficiency (information transfer rate (ITR) and subjective workload) and users' satisfaction. RESULTS:Online performance varied strongly across users and sessions (median accuracy (%) of end-users: A=.65; B=.60; C=.47; D=.77). Our results thus yielded low to medium effectiveness in three end-users and high effectiveness in one end-user. Consequently, ITR was low (0.05-1.44bits/min). Only two end-users were able to play the game in free-mode. Total workload was moderate but varied strongly across sessions. Main sources of workload were mental and temporal demand. Furthermore, frustration contributed to the subjective workload of two end-users. Nevertheless, most end-users accepted the BCI application well and rated satisfaction medium to high. Sources for dissatisfaction were (1) electrode gel and cap, (2) low effectiveness, (3) time-consuming adjustment and (4) not easy-to-use BCI equipment. All four end-users indicated ease of use as being one of the most important aspect of BCI. CONCLUSION:Effectiveness and efficiency are lower as compared to applications using the event-related potential as input channel. Nevertheless, the SMR-BCI application was satisfactorily accepted by the end-users and two of four could imagine using the BCI application in their daily life. Thus, despite moderate effectiveness and efficiency BCIs might be an option when controlling an application for entertainment.
journal_name
Artif Intell Medjournal_title
Artificial intelligence in medicineauthors
Holz EM,Höhne J,Staiger-Sälzer P,Tangermann M,Kübler Adoi
10.1016/j.artmed.2013.08.001subject
Has Abstractpub_date
2013-10-01 00:00:00pages
111-20issue
2eissn
0933-3657issn
1873-2860pii
S0933-3657(13)00114-0journal_volume
59pub_type
杂志文章abstract::The automated analysis of retinal images is a widely researched area which can help to diagnose several diseases like diabetic retinopathy in early stages of the disease. More specifically, separation of vessels and lesions is very critical as features of these structures are directly related to the diagnosis and trea...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2019.07.010
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:Gene Ontology (GO) has become a routine resource for functional analysis of gene lists. Although a number of tools have been provided to identify enriched GO terms in one or two gene lists, two technical challenges remain. First, how to handle multiple hypothesis testing in the analysis given that the tests a...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2007.08.002
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:Suitable techniques for microarray analysis have been widely researched, particularly for the study of marker genes expressed to a specific type of cancer. Most of the machine learning methods that have been applied to significant gene selection focus on the classification ability rather than the selection ab...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2011.06.008
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:In this paper a new nonlinear system identification approach is developed for dynamical quantification of cardiovascular regulation. This approach is specifically focused on the identification of the heart rate (HR) baroreflex mechanism. The principal objective of this paper is to improve the model accuracy i...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2011.01.002
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVES:Access to the world wide web and multimedia content is an important aspect of life. We present a web browser and a multimedia user interface adapted for control with a brain-computer interface (BCI) which can be used by severely motor impaired persons. METHODS:The web browser dynamically determines the most...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2014.12.001
更新日期:2015-01-01 00:00:00
abstract::Pressure injuries represent a tremendous healthcare challenge in many nations. Elderly and disabled people are the most affected by this fast growing disease. Hence, an accurate diagnosis of pressure injuries is paramount for efficient treatment. The characteristics of these wounds are crucial indicators for the progr...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2019.101742
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The successful preparation of cells for therapy depends on the characterization of causal factors affecting cell quality. Ultra scale-down methods are used to characterize cells in terms of their response to process engineering causal factors of hydrodynamic shear stress and time. This response is in turn cha...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2014.07.003
更新日期:2014-10-01 00:00:00
abstract::Knowledge discovery from omics data has become a common goal of current approaches to personalised cancer medicine and understanding cancer genotype and phenotype. However, high-throughput biomedical datasets are characterised by high dimensionality and relatively small sample sizes with small signal-to-noise ratios. ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101821
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:The objective of this paper is to classify 3D medical images by analyzing spatial distributions to model and characterize the arrangement of the regions of interest (ROIs) in 3D space. METHODS AND MATERIAL:Two methods are proposed for facilitating such classification. The first method uses measures of simila...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2004.07.001
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:Our goal is to propose and solve a new formulation of the recently-formalized patient admission scheduling problem, extending it by including several real-world features, such as the presence of emergency patients, uncertainty in the length of stay, and the possibility of delayed admissions. METHOD:We devise...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2012.09.001
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:We present the implementation and application of a case-based reasoning (CBR) system for breast cancer related diagnoses. By retrieving similar cases in a breast cancer decision support system, oncologists can obtain powerful information or knowledge, complementing their own experiential knowledge, in their m...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2017.02.003
更新日期:2017-03-01 00:00:00
abstract::Accounting for patients with multiple health conditions is a complex task that requires analysing potential interactions among recommendations meant to address each condition. Although some approaches have been proposed to address this issue, important features still require more investigation, such as (re)usability a...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2017.03.012
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:The objective of this work is to investigate a possibility of creating a computer-aided decision support system for an automated analysis of vocal cord images aiming to categorize diseases of vocal cords. METHODOLOGY:The problem is treated as a pattern recognition task. To obtain a concise and informative re...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2004.11.001
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:This paper presents continued research toward the development of a knowledge-based system for the diagnosis of human toxic exposures. In particular, this research focuses on the challenging task of diagnosing exposures to multiple toxins. Although only 10% of toxic exposures in the United States involve multi...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2013.02.002
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Motor vehicle accidents (MVA) represent a significant burden on health systems globally. Tens of thousands of people are injured in Australia every year and may experience significant disability. Associated economic costs are substantial. There is little literature on the health service utilization patterns ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101997
更新日期:2021-01-01 00:00:00
abstract:MOTIVATION:Prescribing cascade (PC) occurs when an adverse drug reaction (ADR) is misinterpreted as a new medical condition, leading to further prescriptions for treatment. Additional prescriptions, however, may worsen the existing condition or introduce additional adverse effects (AEs). Timely detection and prevention...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2016.06.002
更新日期:2016-07-01 00:00:00
abstract::Manual delineation of vestibular schwannoma (VS) by magnetic resonance (MR) imaging is required for diagnosis, radiosurgery dose planning, and follow-up tumor volume measurement. A rapid and objective automatic segmentation method is required, but problems have been encountered due to the low through-plane resolution ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101911
更新日期:2020-07-01 00:00:00
abstract::In this contribution we present an application of a knowledge-based neural network technique in the domain of medical research. We consider the crucial problem of intensive care patients developing a septic shock during their stay at the intensive care unit. Septic shock is of prime importance in intensive care medici...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(03)00057-5
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:The current situation of critical progression in resistance to more effective antibiotics has forced the reuse of old highly toxic antibiotics and, for several reasons, the extension of the indications of combined antibiotic therapy as alternative options to broad spectrum empirical mono-therapy. A key aspec...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2019.101751
更新日期:2020-01-01 00:00:00
abstract::This work presents a hybrid expert system (HES) intended to minimise some complex problems pervasive to knowledge engineering such as: the knowledge elicitation process, known as the bottleneck of expert systems; the choice of a model for knowledge representation to codify human reasoning; the number of neurons in the...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(00)00090-7
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:The aim of this paper is to provide an improved method for solving the so-called dynamic patient admission scheduling (DPAS) problem. This is a complex scheduling problem that involves assigning a set of patients to hospital beds over a given time horizon in such a way that several quality measures reflecting...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2016.10.002
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:High dose radiation has been well known for increasing the risk of carcinogenesis. However, the understanding of biological effects of low dose radiation is limited. Low dose radiation is reported to affect several signaling pathways including deoxyribonucleic acid repair, survival, cell cycle, cell growth, a...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2010.04.001
更新日期:2010-07-01 00:00:00
abstract::Cancer is a fatal disease, responsible for one-quarter of all deaths in developed countries. Traditional anticancer therapies such as, chemotherapy and radiation, are highly expensive, susceptible to errors and ineffective techniques. These conventional techniques induce severe side-effects on human cells. Due to peri...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2017.06.008
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:The amount of new discoveries (as published in the scientific literature) in the biomedical area is growing at an exponential rate. This growth makes it very difficult to filter the most relevant results, and thus the extraction of the core information becomes very expensive. Therefore, there is a growing int...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2006.08.005
更新日期:2007-02-01 00:00:00
abstract::Computer-aided detection (CADe) systems play a crucial role in pulmonary nodule detection via chest radiographs (CXRs). A two-stage CADe scheme usually includes nodule candidate detection and false positive reduction. A pure deep learning model, such as faster region convolutional neural network (faster R-CNN), has be...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101881
更新日期:2020-07-01 00:00:00
abstract::The research at the IIIA has produced over more than a decade two versions of a tool for developing knowledge-based systems: Milord and Milord II. This tool has been mainly used for the development of medical applications. In this paper we summarize the Milord II approximate reasoning approach based on fuzzy sets, and...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(00)00080-4
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:In the last few years several complete genome sequences have been made available to the research community. The annotation of their complete inventory of protein coding genes, however, has been so far an elusive goal. Classical ab initio gene prediction methods have been of great support for this task, but sh...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2008.07.015
更新日期:2009-02-01 00:00:00
abstract::INTERNIST-I was an expert system designed in the early 1970's to diagnose multiple diseases in internal medicine by modelling the behaviour of clinicians. Its form and operation are described, and evaluations of the system are surveyed. The major result of the project was its knowledge base which has been used in succ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/0933-3657(94)00028-q
更新日期:1995-04-01 00:00:00
abstract::Electronic medical records (EMRs) contain a wealth of knowledge that can be used to assist doctors in making clinical decisions like disease diagnosis. Constructing a medical knowledge network (MKN) to link medical concepts in EMRs is an effective way to manage this knowledge. The quality of the diagnostic result made...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101927
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:We address the task of inducing explanatory models from observations and knowledge about candidate biological processes, using the illustrative problem of modeling photosynthesis regulation. METHODS:We cast both models and background knowledge in terms of processes that interact to account for behavior. We a...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2006.04.003
更新日期:2006-07-01 00:00:00