Abstract:
OBJECTIVE:This paper presents continued research toward the development of a knowledge-based system for the diagnosis of human toxic exposures. In particular, this research focuses on the challenging task of diagnosing exposures to multiple toxins. Although only 10% of toxic exposures in the United States involve multiple toxins, multiple exposures account for more than half of all toxin-related fatalities. Using simple medical mathematics, we seek to produce a practical decision support system capable of supplying useful information to aid in the diagnosis of complex cases involving multiple unknown substances. METHODS:The system is automatically trained using data mining techniques to extract prior probabilities and likelihood ratios from a database managed by the Florida Poison Information Center (FPIC). When supplied with observed clinical effects, the system produces a ranked list of the most plausible toxic exposures. During testing, the system diagnosed toxins at three levels: identifying the substance, identifying the toxin's major and minor categories, and identifying the toxin's major category alone. To enable comparison between these three levels, accuracy was calculated as the percentage of exposures correctly identified in top 10% of trained diagnoses. RESULTS:System evaluation utilized a dataset of 8901 multiple exposure cases and 37,617 single exposure cases. Initial system testing using only multiple exposure cases yielded poor results, with diagnosis accuracies ranging from 18.5% to 50.1%. Further investigation revealed that the system's inability to diagnose multiple disorders resulted from insufficient data and that the clinical effects observed in multiple exposures are dominated by a single substance. Including single exposures when training, the system achieved accuracies as high as 83.5% when diagnosing the primary contributors in multiple exposure cases by substance, 86.9% when diagnosing by major and minor categories, and 79.9% when diagnosing by major category alone. CONCLUSIONS:Although the system failed to completely diagnose exposures to multiple toxins, the ability to identify the primary contributor in such cases may prove valuable in aiding medical personnel as they seek to diagnose and treat patients. As time passes and more cases are added to the FPIC database, we believe system accuracy will continue to improve, producing a viable decision support system for clinical toxicology.
journal_name
Artif Intell Medjournal_title
Artificial intelligence in medicineauthors
Schipper JD,Dankel DD 2nd,Arroyo AA,Schauben JLdoi
10.1016/j.artmed.2013.02.002subject
Has Abstractpub_date
2013-05-01 00:00:00pages
15-21issue
1eissn
0933-3657issn
1873-2860pii
S0933-3657(13)00010-9journal_volume
58pub_type
杂志文章abstract:OBJECTIVE:The objective of the present work was to develop and compare methods for automatic detection of bilateral sleep spindles. METHODS AND MATERIALS:All-night sleep electroencephalographic (EEG) recordings of 12 healthy subjects with a median age of 40 years were studied. The data contained 6043 visually scored b...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2007.04.003
更新日期:2007-07-01 00:00:00
abstract::Hospital laboratories perform examination tests upon patients, in order to assist medical diagnosis or therapy progress. Planning and scheduling patient requests for examination tests is a complicated problem because it concerns both minimization of patient stay in hospital and maximization of laboratory resources uti...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(00)00061-0
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:In this paper, we propose a novel algorithm to extract the active intervals of intracardiac electrograms during atrial fibrillation. METHODS:First, we show that the characteristics of the signal waveform at its inflection points are prominent features that are implicitly used by human annotators for distingu...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2018.02.003
更新日期:2018-04-01 00:00:00
abstract::We present a stochastic algorithm that computes threshold circuits designed to discriminate between two classes of computed tomography (CT) images. The algorithm employs a partition of training examples into several classes according to the average grey scale value of images. For each class, a sub-circuit is computed,...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(01)00101-4
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:This work presents a system for a simultaneous non-invasive estimate of the blood glucose level (BGL) and the systolic (SBP) and diastolic (DBP) blood pressure, using a photoplethysmograph (PPG) and machine learning techniques. The method is independent of the person whose values are being measured and does n...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2011.05.001
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:This paper identifies and reviews ethical issues associated with artificial intelligent care providers (AICPs) in mental health care and other helping professions. Specific recommendations are made for the development of ethical codes, guidelines, and the design of AICPs. METHODS:Current developments in the ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2014.06.004
更新日期:2014-09-01 00:00:00
abstract:AIM:A new automatic method for detecting specific points and lines (straight and curves) in dental panoramic radiographies (orthopantomographies) is proposed, where the human knowledge is mapped to the automatic system. The goal is to compute relevant mandibular indices (Mandibular Cortical Width, Panoramic Mandibular ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101816
更新日期:2020-03-01 00:00:00
abstract::We describe an approach for developing knowledge-based medical decision support systems based on the new technology of case-based reasoning. This work is based on the results of the Inreca European project and preliminary results from the Inreca + project which mainly deals with medical applications. One goal was to s...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(97)00038-9
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To assess whether a user-centred prototype clinical decision support system (CDSS) providing patient-specific advice better supports healthcare practitioners in terms of (a) types of usability problems detected and (b) effective and efficient retrieval of childhood cancer survivor's follow-up screening proced...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2013.04.004
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:There is an ongoing research effort devoted to characterize the signal regularity metrics approximate entropy (ApEn) and sample entropy (SampEn) in order to better interpret their results in the context of biomedical signal analysis. Along with this line, this paper addresses the influence of abnormal spikes ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2011.06.007
更新日期:2011-10-01 00:00:00
abstract:MOTIVATION:Prescribing cascade (PC) occurs when an adverse drug reaction (ADR) is misinterpreted as a new medical condition, leading to further prescriptions for treatment. Additional prescriptions, however, may worsen the existing condition or introduce additional adverse effects (AEs). Timely detection and prevention...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2016.06.002
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVES:The existence of proper non-invasive temperature estimators is an essential aspect when thermal therapy applications are envisaged. These estimators must be good predictors to enable temperature estimation at different operational situations, providing better control of the therapeutic instrumentation. In th...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2008.03.008
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:New medical systems may be rejected by staff because they do not integrate with local practice. An expert system, FLORENCE, is being developed to help staff in a neonatal intensive care unit (NICU) make decisions about ventilator settings when treating babies with respiratory distress syndrome. For FLORENCE t...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2005.01.004
更新日期:2005-11-01 00:00:00
abstract::Rough sets (Pawlak Z. Rough Sets: Theoretical Aspects of Reasoning about Data, Dordrecht: Kluwer Academic Publishers, 1991) is a relatively new approach to representing and reasoning with incomplete and uncertain knowledge. This article introduces the basic concepts of rough sets and Boolean reasoning (Brown FM. Boole...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(98)00051-7
更新日期:1999-02-01 00:00:00
abstract::Cancer is a fatal disease, responsible for one-quarter of all deaths in developed countries. Traditional anticancer therapies such as, chemotherapy and radiation, are highly expensive, susceptible to errors and ineffective techniques. These conventional techniques induce severe side-effects on human cells. Due to peri...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2017.06.008
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:In the last few years several complete genome sequences have been made available to the research community. The annotation of their complete inventory of protein coding genes, however, has been so far an elusive goal. Classical ab initio gene prediction methods have been of great support for this task, but sh...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2008.07.015
更新日期:2009-02-01 00:00:00
abstract::During the appointment booking process in out-patient departments, the level of patient satisfaction can be affected by whether or not their preferences can be met, including the choice of physicians and preferred time slot. In addition, because the appointments are sequential, considering future possible requests is ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2018.02.001
更新日期:2018-04-01 00:00:00
abstract::The decompressive laminectomy is a common operation for treatment of lumbar spinal stenosis. The tools for grinding and drilling are used for fenestration and internal fixation, respectively. The state recognition is one of the main technologies in robot-assisted surgery, especially in tele-surgery, because surgeons h...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2019.101763
更新日期:2020-01-01 00:00:00
abstract::Allowing exchange of information and cooperation among network-wide distributed and heterogeneous applications is a major need of current health-care information systems. The European project SynEx aims at developing an integration platform for both new and legacy applications on each partner's site. We developed, in ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(03)00007-1
更新日期:2003-03-01 00:00:00
abstract::Automatic arrhythmia detection based on electrocardiogram (ECG) is of great significance for early prevention and diagnosis of cardiac diseases. Recently, deep learning methods have been applied to arrhythmia detection and obtained great success. Among them, convolutional neural network (CNN) is an effective method fo...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101856
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:A major focus in computational system biology research is defining organizing principles that govern complex biological network formation and evolution. The task is considered a major challenge because network behavior and function prediction requires the identification of functionally and statistically impor...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2007.07.006
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:Sketching is ubiquitous in medicine. Physicians commonly use sketches as part of their note taking in patient records and to help convey diagnoses and treatments to patients. Medical students frequently use sketches to help them think through clinical problems in individual and group problem solving. Applicat...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2006.07.010
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Motor vehicle accidents (MVA) represent a significant burden on health systems globally. Tens of thousands of people are injured in Australia every year and may experience significant disability. Associated economic costs are substantial. There is little literature on the health service utilization patterns ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101997
更新日期:2021-01-01 00:00:00
abstract::Deregulated splicing machinery components have shown to be associated with the development of several types of cancer and, therefore, the determination of such alterations can help the development of tumor-specific molecular targets for early prognosis and therapy. Determining such splicing components, however, is not...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101950
更新日期:2020-08-01 00:00:00
abstract::To explore the design of computer-supported collaborative work in health care, a case study is described addressing the social contexts and conditions influencing the development process. The data set covers 13 consecutive meetings held in a systems design group over a 2-year period, in total approximately 24 h of vid...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(97)00046-8
更新日期:1998-02-01 00:00:00
abstract::INTERNIST-I was an expert system designed in the early 1970's to diagnose multiple diseases in internal medicine by modelling the behaviour of clinicians. Its form and operation are described, and evaluations of the system are surveyed. The major result of the project was its knowledge base which has been used in succ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/0933-3657(94)00028-q
更新日期:1995-04-01 00:00:00
abstract::Over the years, there has been growing interest in using machine learning techniques for biomedical data processing. When tackling these tasks, one needs to bear in mind that biomedical data depends on a variety of characteristics, such as demographic aspects (age, gender, etc.) or the acquisition technology, which mi...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101804
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:This paper proposes a novel method for the extraction and classification of individual motor unit action potentials (MUAPs) from intramuscular electromyographic signals. METHODOLOGY:The proposed method automatically detects the number of template MUAP clusters and classifies them into normal, neuropathic or ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2005.09.002
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:The objective of this work is to investigate a possibility of creating a computer-aided decision support system for an automated analysis of vocal cord images aiming to categorize diseases of vocal cords. METHODOLOGY:The problem is treated as a pattern recognition task. To obtain a concise and informative re...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2004.11.001
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:This work proposes creating an automatic system to locate and segment the optic nerve head (ONH) in eye fundus photographic images using genetic algorithms. METHODS AND MATERIAL:Domain knowledge is used to create a set of heuristics that guide the various steps involved in the process. Initially, using an ey...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2008.04.005
更新日期:2008-07-01 00:00:00