Abstract:
:A crush-avulsion anastomosis model was established on the rat femoral vein. Saline or heparin was used as a luminal topical agent and was allowed to contact the damaged endothelium for 10 min. Patency and coagulation parameters were investigated for 1 week. The heparin treated group had a patency rate of 93% at 1 hr vs. 13% for the saline treated group (P < 0.001). At 7 days, the heparin treated group had an 87% patency vs. 7% for the saline-treated group (P < 0.001). Scanning electron micrography (SEM) provided evidence of the deposition of the components of early thrombosis in the crushed venous wall. In contrast, the SEM of the heparin treated group shows a paucity of any evidence of thrombus. These results indicate that the rat vein crush-avulsion model is a reliable and reproducible thrombosis model with low patency. The methods used with the topical agent may improve the patency rate in crush avulsion injuries.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Fu K,Izquierdo R,Hubbard T,Fareed Jdoi
10.1002/micr.1920160806subject
Has Abstractpub_date
1995-01-01 00:00:00pages
536-41issue
8eissn
0738-1085issn
1098-2752journal_volume
16pub_type
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