Hypopituitarism in pediatric survivors of inflicted traumatic brain injury.

abstract：:Mild traumatic brain injury (mTBI) disrupts hippocampal function and can lead to long-lasting episodic memory impairments. The encoding of episodic memories relies on spatial information processing within the hippocampus. As the primary entry point for spatial information into the hippocampus, the dentate gyrus is tho...

journal_title：Journal of neurotrauma

authors： Folweiler KA,Samuel S,Metheny HE,Cohen AS

更新日期：2018-06-01 00:00:00

abstract：:The fluid-percussion technique produces experimental brain injury by rapid injection of a fluid volume into the closed cranial cavity. The experiments reported here characterize a new, more controlled technique for fluid-percussion brain injury in the rat and systematically examine systemic physiologic, histopathologi...

journal_title：Journal of neurotrauma

authors： Dixon CE,Lighthall JW,Anderson TE

更新日期：1988-01-01 00:00:00

abstract：:Anatomical studies of spinal cord injury (SCI) using magnetic resonance imaging (MRI) report diverging observations, from "no changes" to "tissue atrophy in motor and non-motor regions." These discrepancies among studies can be attributed to heterogeneity in extent, level, and post-injury duration observed within the ...

journal_title：Journal of neurotrauma

authors： Karunakaran KD,He J,Zhao J,Cui JL,Zang YF,Zhang Z,Biswal BB

更新日期：2019-06-15 00:00:00

abstract：:Head injury patients not meeting the American Congress of Rehabilitation Medicine (ACRM)'s criteria for mild traumatic brain injury (mTBI), referred to hereafter as HIBRID (Head Injury BRain Injury Debatable), are often excluded from studies. The prognostic importance of HIBRID is unclear. We investigated the differen...

journal_title：Journal of neurotrauma

authors： Korley FK,Diaz-Arrastia R,Falk HJ,Peters ME,Leoutsakos JS,Roy D,Rao V,Sair HI,Ofoche U,Hall AJ,Akbari F,Van Meter TE,Everett AD,Van Eyk JE,Bechtold KT

更新日期：2017-04-15 00:00:00

abstract：:Blast injury to the brain is one of the major causes of death and can also significantly affect cognition and physical and psychological skills in survivors of blast. The complex mechanisms via which blast injury causes impairment of cognition and other symptoms are poorly understood. In this study, we investigated th...

journal_title：Journal of neurotrauma

authors： Lu J,Ng KC,Ling G,Wu J,Poon DJ,Kan EM,Tan MH,Wu YJ,Li P,Moochhala S,Yap E,Lee LK,Teo M,Yeh IB,Sergio DM,Chua F,Kumar SD,Ling EA

更新日期：2012-05-01 00:00:00

abstract：:Striatal-enriched tyrosine phosphatase (STEP) has been identified as a component of physiological and pathophysiological signaling pathways mediated by N-methyl-d-aspartate (NMDA) receptor/calcineurin/calpain activation. Activation of these pathways produces a subsequent change in STEP isoform expression or activation...

journal_title：Journal of neurotrauma

authors： Mesfin MN,von Reyn CR,Mott RE,Putt ME,Meaney DF

更新日期：2012-07-01 00:00:00

abstract：:Information on the nature of deficits and adaptive mechanisms occurring after spinal cord injury is essential to the design of strategies for promoting functional recovery. Motor impairments and compensations were quantified by three-dimensional kinematic analysis in freely walking rats, 6 months after mild cervical (...

journal_title：Journal of neurotrauma

authors： Collazos-Castro JE,Soto VM,Gutiérrez-Dávila M,Nieto-Sampedro M

更新日期：2005-05-01 00:00:00

abstract：:Neuropathic pain and motor deficits are detrimental consequences of injury to the spinal cord. In experimental settings, numerous neuroprotective agents are being explored for their therapeutic benefits. Vascular endothelial growth factor (VEGF) is an interesting candidate molecule in this respect since it is not only...

journal_title：Journal of neurotrauma

authors： van Neerven S,Joosten EA,Brook GA,Lambert CA,Mey J,Weis J,Marcus MA,Steinbusch HW,van Kleef M,Patijn J,Deumens R

更新日期：2010-10-01 00:00:00

abstract：:Clinical studies have documented the importance of secondary brain insults in determining neurologic outcome after head injury. Delayed intracranial hematomas are one of the most easily remediable causes of secondary injury if identified early, but can cause significant disability or death if not promptly recognized a...

journal_title：Journal of neurotrauma

authors： Robertson CS,Gopinath SP,Chance B

更新日期：1995-08-01 00:00:00

abstract：:Depression is associated with poorer recovery after traumatic brain injury (TBI), yet awareness of depression risk post-TBI among providers and patients is low. The aim of this study was to estimate risk of depression post-TBI among adults 18 years of age and older and to identify risk factors associated with developi...

journal_title：Journal of neurotrauma

authors： Albrecht JS,Barbour L,Abariga SA,Rao V,Perfetto EM

更新日期：2019-01-15 00:00:00

abstract：:Prevention of the immediate excitotoxic phase occurring in response to spinal cord injury (SCI) is a major issue to reduce the neuronal damage responsible for any ensuing motor deficits. The present study evaluated the neuroprotective efficacy of three noncompetitive NMDA receptor antagonists: Gacyclidine (GK-11), a n...

journal_title：Journal of neurotrauma

authors： Feldblum S,Arnaud S,Simon M,Rabin O,D'Arbigny P

更新日期：2000-11-01 00:00:00

abstract：:Acute subdural hematoma (ASDH) is associated with high morbidity and mortality. Whether the volume effect of the hematoma and increase of intracranial pressure (ICP) or the local effect of blood are responsible for this severe pathophysiology is unclear. Therefore, we compared subdural infusion of autologous blood and...

journal_title：Journal of neurotrauma

authors： Jussen D,Krenzlin H,Papaioannou C,Ens S,Kempski O,Alessandri B

更新日期：2017-02-15 00:00:00

abstract：:Remarkable advances have been made in pharmacologic treatments of acute and chronic spinal cord injury. The recent National Acute Spinal Cord Injury Study (NASCIS) showed that very high dose methylprednisolone given within 8 hr after injury improves neurologic recovery. The mechanism is believed to be inhibition of li...

journal_title：Journal of neurotrauma

authors： Nockels R,Young W

更新日期：1992-03-01 00:00:00

abstract：:The role of endothelin (ET) in the pathophysiology of secondary neural damage after experimental spinal cord injury (SCI) was examined in a rat model of weight-drop contusion injury. Initial studies demonstrated a significant increase in spinal ET concentrations in a 7.5-mm segment of tissue (centered at the impact si...

journal_title：Journal of neurotrauma

authors： Salzman SK,Acosta R,Beck G,Madden J,Boxer B,Ohlstein EH

更新日期：1996-02-01 00:00:00

abstract：:Despite an improved understanding of traumatic head and neck injury mechanisms, the impact tests required by major motorcycle helmet standards have remained unchanged for decades. Development of new test methods must reflect the specific impact loads causing injury in real crashes as well as test criteria appropriate ...

journal_title：Journal of neurotrauma

authors： Whyte T,Gibson T,Anderson R,Eager D,Milthorpe B

更新日期：2016-10-01 00:00:00

abstract：:The current lack of diagnostic and prognostic biomarkers for traumatic brain injury (TBI) confounds treatment and management of patients and is of increasing concern as the TBI population grows. We have generated plasma proteomic profiles from mice receiving TBI by controlled cortical impact at either 1.3 mm or 1.8 mm...

journal_title：Journal of neurotrauma

authors： Crawford F,Crynen G,Reed J,Mouzon B,Bishop A,Katz B,Ferguson S,Phillips J,Ganapathi V,Mathura V,Roses A,Mullan M

更新日期：2012-01-20 00:00:00

abstract：:The goal of this investigation was to develop a method to study the neurophysiological integrity of the central motor tract using motor evoked potentials in the awake rat and assess the effects of different anesthetics in this model. Rats were implanted with six subcutaneous electrodes (pediatric myocardial pacing lea...

journal_title：Journal of neurotrauma

authors： Oria M,Chatauret N,Raguer N,Córdoba J

更新日期：2008-03-01 00:00:00

abstract：:The lectin pathway of the complement system has been implicated in secondary ischemic/inflammatory injury after traumatic brain injury (TBI). However, previous experimental studies have yielded conflicting results, and human studies are scarce. In this exploratory study, we investigated associations of several lectin ...

journal_title：Journal of neurotrauma

authors： Osthoff M,Walder B,Delhumeau C,Trendelenburg M,Turck N

更新日期：2017-09-01 00:00:00

abstract：:Acute subdural hemorrhage (ASDH) is common and associated with severe morbidity and mortality. To date, the role of spontaneous cortical spreading depression (sCSD) in exaggerating secondary injury after ASDH, is poorly understood. The present study contains two experimental groups: First, we investigated and characte...

journal_title：Journal of neurotrauma

authors： Krenzlin H,Jussen D,Plath M,Tretzel SJ,Krämer T,Kempski O,Alessandri B

更新日期：2019-01-15 00:00:00

abstract：:Studies measuring the volume of infarcted tissue and survival after pharmacologic intervention in stroke are complicated by the potential effect of survival time on infarct volume. In this study, the volume of infarcted tissue as defined by 2,3,5-triphenyltetrazolium chloride staining was determined in rabbits at 28 h...

journal_title：Journal of neurotrauma

authors： Browning JL,Widmayer MA,Hoffmann KK,Dudley AW Jr,Baskin DS

更新日期：1996-10-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is commonly observed in military service members with mild traumatic brain injury (mTBI); however, the relationship between mTBI and PTSD is complex and not well understood. The present study aims to elucidate a link between the degree of alteration in limbic system-related white ...

journal_title：Journal of neurotrauma

authors： Santhanam P,Teslovich T,Wilson SH,Yeh PH,Oakes TR,Weaver LK

更新日期：2019-04-01 00:00:00

abstract：:Post-traumatic epilepsy (PTE) is a consequence of traumatic brain injury (TBI), occurring in 10-25% of patients with moderate to severe injuries. The development of animal models for testing antiepileptogenic therapies and validation of biomarkers to follow epileptogenesis in humans necessitates sophisticated understa...

journal_title：Journal of neurotrauma

authors： Gupta PK,Sayed N,Ding K,Agostini MA,Van Ness PC,Yablon S,Madden C,Mickey B,D'Ambrosio R,Diaz-Arrastia R

更新日期：2014-08-15 00:00:00

abstract：:To examine the mechanism of the increase in cerebral blood flow induced by L-arginine administration after traumatic brain injury, the cerebral hemodynamic effects of L-arginine, D-arginine, and the free radical scavengers superoxide dismutase (SOD) and catalase were compared in the controlled cortical impact injury m...

journal_title：Journal of neurotrauma

authors： Cherian L,Robertson CS

更新日期：2003-01-01 00:00:00

abstract：:Although chronic sleepiness is common after head trauma, the cause remains unclear. Transcranial magnetic stimulation (TMS) represents a useful complementary approach in the study of sleep pathophysiology. We aimed to determine in this study whether post-traumatic sleep-wake disturbances (SWD) are associated with chan...

journal_title：Journal of neurotrauma

authors： Nardone R,Bergmann J,Kunz A,Caleri F,Seidl M,Tezzon F,Gerstenbrand F,Trinka E,Golaszewski S

更新日期：2011-07-01 00:00:00

abstract：:Traumatic brain injury (TBI) has been identified as a risk factor for Alzheimer's disease (AD). However, how such neural damage contributes to AD pathology remains unclear; specifically, the relationship between the timing of a TBI relative to aging and the onset of AD pathology is not known. In this study, we have ex...

journal_title：Journal of neurotrauma

authors： Collins JM,King AE,Woodhouse A,Kirkcaldie MTK,Vickers JC

更新日期：2019-06-01 00:00:00

abstract：:Perceived injustice is a belief that one has been treated unfairly and disrespectfully, and is suffering unnecessarily as a result of another person's actions. Perceived injustice predicts chronic disability after musculoskeletal injury but to our knowledge has not been empirically studied in people with mild traumati...

journal_title：Journal of neurotrauma

authors： Iverson GL,Terry DP,Karr JE,Panenka WJ,Silverberg ND

更新日期：2018-05-15 00:00:00

abstract：:Few studies have assessed the long-term functional outcomes of patients with a disorder of consciousness due to traumatic brain injury (TBI). This study examined functional status during the first 10 years after TBI among a cohort with disorders of consciousness (i.e., coma, vegetative state, minimally conscious state...

journal_title：Journal of neurotrauma

authors： Hammond FM,Giacino JT,Nakase Richardson R,Sherer M,Zafonte RD,Whyte J,Arciniegas DB,Tang X

更新日期：2019-04-01 00:00:00

abstract：:Efforts to understand spinal cord injury (SCI) and other complex neurotrauma disorders at the pre-clinical level have shown progress in recent years. However, successful translation of basic research into clinical practice has been slow, partly because of the large, heterogeneous data sets involved. In this sense, tra...

journal_title：Journal of neurotrauma

authors： Nielson JL,Guandique CF,Liu AW,Burke DA,Lash AT,Moseanko R,Hawbecker S,Strand SC,Zdunowski S,Irvine KA,Brock JH,Nout-Lomas YS,Gensel JC,Anderson KD,Segal MR,Rosenzweig ES,Magnuson DS,Whittemore SR,McTigue DM,Popovic

更新日期：2014-11-01 00:00:00

abstract：:Formation of a glial scar is one of the major obstacles to axonal growth after injury to the adult CNS. In this study, we have addressed this issue by focusing on reactive astrocytes in a mouse model of spinal cord injury (SCI). First, we attempted to identify profile changes in the expression of astrocytic gliosis 10...

journal_title：Journal of neurotrauma

authors： Ito M,Natsume A,Takeuchi H,Shimato S,Ohno M,Wakabayashi T,Yoshida J

更新日期：2009-01-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) play a key role in tissue repair and regeneration. Previous studies have shown a positive correlation between the number of circulating EPCs and clinical outcomes of patients with traumatic brain injury (TBI). A recent study has further shown that intravenous infusion of human umbil...

journal_title：Journal of neurotrauma

authors： Huang XT,Zhang YQ,Li SJ,Li SH,Tang Q,Wang ZT,Dong JF,Zhang JN

更新日期：2013-12-15 00:00:00