The role of Djp1 in import of the mitochondrial protein Mim1 demonstrates specificity between a cochaperone and its substrate protein.

abstract：:In self-renewing tissues such as the skin epidermis and the bone marrow, Myc proteins control differentiation of stem cells and proliferation of progenitor cell types. In the epithelium of the small intestine, we show that c-Myc and N-Myc are expressed in a differential manner. Whereas c-Myc is expressed in the prolif...

journal_title：Molecular and cellular biology

authors： Bettess MD,Dubois N,Murphy MJ,Dubey C,Roger C,Robine S,Trumpp A

更新日期：2005-09-01 00:00:00

abstract：:The intracellular signaling mechanisms underlying the pathogenesis of cardiac diseases are not fully understood. We report here that selective deletion of Shp2, an SH2-containing cytoplasmic tyrosine phosphatase, in striated muscle results in severe dilated cardiomyopathy in mice, leading to heart failure and prematur...

journal_title：Molecular and cellular biology

authors： Princen F,Bard E,Sheikh F,Zhang SS,Wang J,Zago WM,Wu D,Trelles RD,Bailly-Maitre B,Kahn CR,Chen Y,Reed JC,Tong GG,Mercola M,Chen J,Feng GS

更新日期：2009-01-01 00:00:00

abstract：:Following hepatic injury or stress, gluconeogenic and acute-phase response genes are rapidly upregulated to restore metabolic homeostasis and limit tissue damage. Regulation of the liver-restricted insulin-like growth factor binding protein 1 (IGFBP-1) gene is dramatically altered by changes in the metabolic state and...

journal_title：Molecular and cellular biology

authors： Leu JI,Crissey MA,Leu JP,Ciliberto G,Taub R

更新日期：2001-01-01 00:00:00

abstract：:The interaction of the retinoblastoma susceptibility gene product (Rb)-related p107 protein with the E2F transcription factor in S-phase cells facilitates the formation of a multicomponent complex also containing cyclin A and the p33cdk2 kinase. We have created a series of p107 mutants to assess the ability of p107 to...

journal_title：Molecular and cellular biology

authors： Smith EJ,Nevins JR

更新日期：1995-01-01 00:00:00

abstract：:Hydroxyurea (HU) is a DNA replication inhibitor that negatively affects both the elongation and initiation phases of replication and triggers the "intra-S phase checkpoint." Previous work with budding yeast has shown that, during a short exposure to HU, MEC1/RAD53 prevent initiation at some late S phase origins. In th...

journal_title：Molecular and cellular biology

authors： Alvino GM,Collingwood D,Murphy JM,Delrow J,Brewer BJ,Raghuraman MK

更新日期：2007-09-01 00:00:00

abstract：:The cytokines tumor necrosis factor (TNF), beta interferon (IFN-beta), and IFN-gamma increase major histocompatibility complex class I molecule expression. A greater than additive (i.e., synergistic) induction of class I heavy-chain mRNA is observed in HeLa cells treated with TNF in combination with either type of IFN...

journal_title：Molecular and cellular biology

authors： Johnson DR,Pober JS

更新日期：1994-02-01 00:00:00

abstract：:The 5' ends of dihydrofolate reductase (DHFR)-specific transcripts have been mapped in the 5'-flanking region of the amplified DHFR gene of the human methotrexate-resistant cell line 6A3 by primer extension and S1 protection experiments. The main 5' end, at position -71 relative to the first nucleotide of the DHFR rea...

journal_title：Molecular and cellular biology

authors： Masters JN,Attardi G

更新日期：1985-03-01 00:00:00

abstract：:We describe a genetic transformation system which should prove useful for investigating tropomyosin assembly and function. Muscle abnormalities associated with a defective tropomyosin allele were corrected by integrating the wild-type gene into germ line chromosomes. The transformation protocol permits application of ...

journal_title：Molecular and cellular biology

authors： Fyrberg EA,Karlik CC

更新日期：1987-08-01 00:00:00

abstract：:The genes of the trithorax group (trxG) in Drosophila melanogaster are required to maintain the pattern of homeotic gene expression that is established early in embryogenesis by the transient expression of the segmentation genes. The precise role of each of the diverse trxG members and the functional relationships amo...

journal_title：Molecular and cellular biology

authors： Crosby MA,Miller C,Alon T,Watson KL,Verrijzer CP,Goldman-Levi R,Zak NB

更新日期：1999-02-01 00:00:00

abstract：:The pathway of vesicular stomatitis virus N protein from synthesis to assembly into capsids was studied by use of detergent extraction of infected HeLa cells together with protein cross-linking. One half of the newly synthesized N protein was extracted with the soluble cell proteins and, when cross-linked, never forme...

journal_title：Molecular and cellular biology

authors： Chatterjee PK,Cervera MM,Penman S

更新日期：1984-10-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent angiogenic inducer that stimulates the expression of tissue factor (TF), the major cellular initiator of blood coagulation. Here we show that signaling triggered by VEGF induced DNA-binding and transcriptional activities of nuclear factor of activated T cells (NFAT...

journal_title：Molecular and cellular biology

authors： Armesilla AL,Lorenzo E,Gómez del Arco P,Martínez-Martínez S,Alfranca A,Redondo JM

更新日期：1999-03-01 00:00:00

abstract：:Mammary epithelial cells (MECs) detached from the extracellular matrix (ECM) produce deleterious reactive oxygen species (ROS) and induce autophagy to survive. The coordination of such opposing responses likely dictates whether epithelial cells survive ECM detachment or undergo anoikis. Here, we demonstrate that the e...

journal_title：Molecular and cellular biology

authors： Avivar-Valderas A,Salas E,Bobrovnikova-Marjon E,Diehl JA,Nagi C,Debnath J,Aguirre-Ghiso JA

更新日期：2011-09-01 00:00:00

abstract：:White adipose tissue (WAT) serves as a reversible energy storage depot in the form of lipids in response to nutritional status. Cavin-1, an essential component in the biogenesis of caveolae, is a positive regulator of lipolysis in adipocytes. However, molecular mechanisms of cavin-1 in the modulation of lipolysis rema...

journal_title：Molecular and cellular biology

authors： Zhou SR,Guo L,Wang X,Liu Y,Peng WQ,Liu Y,Wei XB,Dou X,Ding M,Lei QY,Qian SW,Li X,Tang QQ

更新日期：2017-07-28 00:00:00

abstract：:The DNA single-strand break repair (SSBR) protein XRCC1 is required for genetic stability and for embryonic viability. XRCC1 possesses two BRCA1 carboxyl-terminal (BRCT) protein interaction domains, denoted BRCT I and II. BRCT II is required for SSBR during G(1) but is dispensable for this process during S/G(2) and co...

journal_title：Molecular and cellular biology

authors： Taylor RM,Thistlethwaite A,Caldecott KW

更新日期：2002-04-01 00:00:00

abstract：:The onc gene (v-fes) of the acutely transforming feline sarcoma virus (Snyder-Theilen strain) has homologous cellular sequences (c-fes) in all vertebrate species, including humans. We isolated from a human DNA library recombinant phages containing overlapping c-fes sequences. The human c-fes locus spans a region of 3....

journal_title：Molecular and cellular biology

authors： Franchini G,Gelmann EP,Dalla-Favera R,Gallo RC,Wong-Staal F

更新日期：1982-08-01 00:00:00

abstract：:Hepatocyte nuclear factor 4 (HNF-4), a highly conserved member of the steroid hormone receptor superfamily critical for development and liver-specific gene expression, is very similar to another superfamily member, retinoid X receptor alpha (RXR alpha), in overall amino acid sequence and DNA binding specificity. Since...

journal_title：Molecular and cellular biology

authors： Jiang G,Nepomuceno L,Hopkins K,Sladek FM

更新日期：1995-09-01 00:00:00

abstract：:Bach2 is a B-cell- and neuron-specific transcription repressor that forms heterodimers with the Maf-related oncoproteins. We show here that Bach2 activates transcription by interacting with its novel partner MAZR. MAZR was isolated by the yeast two-hybrid screen using the BTB/POZ domain of Bach2 as bait. Besides the B...

journal_title：Molecular and cellular biology

authors： Kobayashi A,Yamagiwa H,Hoshino H,Muto A,Sato K,Morita M,Hayashi N,Yamamoto M,Igarashi K

更新日期：2000-03-01 00:00:00

abstract：:Human La protein has been shown to serve as a transcription factor for RNA polymerase III (pol III) by facilitating transcription termination and recycling of transcription complexes. In addition, La binds to the 3' oligo(U) ends common to all nascent pol III transcripts, and in the case of B1-Alu RNA, protects it fro...

journal_title：Molecular and cellular biology

authors： Goodier JL,Fan H,Maraia RJ

更新日期：1997-10-01 00:00:00

abstract：:We have measured the frequency of meiotic recombination between marked Ty elements in the Saccharomyces cerevisiae genome. These recombination events were usually nonreciprocal (gene conversions) and sometimes involved nonhomologous chromosomes. The frequency of ectopic gene conversion among Ty elements appeared lower...

journal_title：Molecular and cellular biology

authors： Kupiec M,Petes TD

更新日期：1988-07-01 00:00:00

abstract：:Sphingomyelin is a major lipid in the bilayer of subcellular membranes of eukaryotic cells. Different sphingomyelinases catalyze the initial step in the catabolism of sphingomyelin, the hydrolysis to phosphocholine and ceramide. Sphingomyelinases have been postulated to generate ceramide as a lipophilic second messeng...

journal_title：Molecular and cellular biology

authors： Zumbansen M,Stoffel W

更新日期：2002-06-01 00:00:00

abstract：:A novel pp90rsk Ser/Thr kinase (referred to as RSK3) was cloned from a human cDNA library. The RSK3 cDNA encodes a predicted 733-amino-acid protein with a unique N-terminal region containing a putative nuclear localization signal. RSK3 mRNA was widely expressed (but was predominant in lung and skeletal muscle). By usi...

journal_title：Molecular and cellular biology

authors： Zhao Y,Bjørbaek C,Weremowicz S,Morton CC,Moller DE

更新日期：1995-08-01 00:00:00

abstract：:Cancer cells may evade immune surveillance as a result of defective antigen processing and presentation. In this study, we demonstrate that CD40 ligation overcomes this defect through the coordinated action of the transcription factors NF-kappaB and interferon regulatory factor 1 (IRF-1). We show that unlike interfero...

journal_title：Molecular and cellular biology

authors： Moschonas A,Kouraki M,Knox PG,Thymiakou E,Kardassis D,Eliopoulos AG

更新日期：2008-10-01 00:00:00

abstract：:We have constructed an ALDH3a1 null mouse to investigate the role of this enzyme that comprises nearly one-half of the total water-soluble protein in the mouse corneal epithelium. ALDH3a1-deficient mice are viable and fertile, have a corneal epithelium with a water-soluble protein content approximately half that of wi...

journal_title：Molecular and cellular biology

authors： Nees DW,Wawrousek EF,Robison WG Jr,Piatigorsky J

更新日期：2002-02-01 00:00:00

abstract：:The cellular transcription factor E2F appears to be a target for the regulatory action of the retinoblastoma tumor suppressor gene product. The recent isolation of the E2F1 cDNA clone, which encodes a polypeptide with properties characteristic of E2F, has now allowed a more detailed analysis of the regulation of E2F f...

journal_title：Molecular and cellular biology

authors： Cress WD,Johnson DG,Nevins JR

更新日期：1993-10-01 00:00:00

abstract：:The myeloperoxidase (MPO) and neutrophil elastase genes are expressed specifically in immature myeloid cells. The integrity of a polyomavirus enhancer core sequence, 5'-AACCACA-3', is critical to the activity of the murine MPO proximal enhancer. This element binds two species, myeloid nuclear factors 1 alpha and 1 bet...

journal_title：Molecular and cellular biology

authors： Nuchprayoon I,Meyers S,Scott LM,Suzow J,Hiebert S,Friedman AD

更新日期：1994-08-01 00:00:00

abstract：:Transcriptional coactivators play a crucial role in gene expression by communicating between regulatory factors and the basal transcription machinery. The coactivator multiprotein bridging factor 1 (MBF1) was originally identified as a bridging molecule that connects the Drosophila nuclear receptor FTZ-F1 and TATA-bin...

journal_title：Molecular and cellular biology

authors： Takemaru K,Harashima S,Ueda H,Hirose S

更新日期：1998-09-01 00:00:00

abstract：:Several eukaryotic transcription factors such as Sp1 or Oct1 contain glutamine-rich domains that mediate transcriptional activation. In human cells, promoter-proximally bound glutamine-rich activation domains activate transcription poorly in the absence of acidic type activators bound at distal enhancers, but synergis...

journal_title：Molecular and cellular biology

authors： Escher D,Bodmer-Glavas M,Barberis A,Schaffner W

更新日期：2000-04-01 00:00:00

abstract：:Caspases play important roles in apoptotic cell death and in some other functions, such as cytokine maturation, inflammation, or differentiation. We show here that the 5'-flanking region of the human CASP-2 gene contains three functional response elements for sterol regulatory element binding proteins (SREBPs), protei...

journal_title：Molecular and cellular biology

authors： Logette E,Le Jossic-Corcos C,Masson D,Solier S,Sequeira-Legrand A,Dugail I,Lemaire-Ewing S,Desoche L,Solary E,Corcos L

更新日期：2005-11-01 00:00:00

abstract：:A variety of genes, including c-myc, are activated by chemical toxicants in vivo and in vitro. Although enforced c-myc expression induces apoptosis after withdrawing survival factors, it is not clear if activation of the endogenous c-myc gene is an apoptotic signal after toxicant exposure. The renal tubular epithelium...

journal_title：Molecular and cellular biology

authors： Zhan Y,Cleveland JL,Stevens JL

更新日期：1997-11-01 00:00:00

abstract：:Scaffold proteins have been established as important mediators of signal transduction specificity. The insulin receptor substrate (IRS) proteins represent a critical group of scaffold proteins that are required for signal transduction by the insulin receptor, including the activation of phosphatidylinositol 3 kinase. ...

journal_title：Molecular and cellular biology

authors： Standen CL,Kennedy NJ,Flavell RA,Davis RJ

更新日期：2009-09-01 00:00:00