Abnormalities of the retinal cone system in retinitis pigmentosa.

Abstract:

:Patients with retinitis pigmentosa (RP) show delayed inner retinal responses as measured by the cone ERG response to a 30 Hz stimulus. To determine the extent to which this delay results from abnormalities of cone phototransduction, cone ERGs to single flashes were obtained from 21 patients with RP and a model of cone phototransduction was fitted to the leading edge of the a-waves of these ERGs. Nearly all patients showed an abnormally low sensitivity of cone phototransduction consistent with a reduction in the amplification of transduction. This abnormality can account for part of the delayed 30 Hz response. Analysis of post-receptoral potentials indicated that RP also slows the responses of the inner retina. A combination of these two factors, a sensitivity change at the receptor and a delay in the response of the inner retina, produces the delayed response of the cone flicker ERG in patients with RP.

journal_name

Vision Res

journal_title

Vision research

authors

Hood DC,Birch DG

doi

10.1016/0042-6989(95)00246-4

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

1699-709

issue

11

eissn

0042-6989

issn

1878-5646

pii

0042-6989(95)00246-4

journal_volume

36

pub_type

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