Abstract:
:Patients with retinitis pigmentosa (RP) show delayed inner retinal responses as measured by the cone ERG response to a 30 Hz stimulus. To determine the extent to which this delay results from abnormalities of cone phototransduction, cone ERGs to single flashes were obtained from 21 patients with RP and a model of cone phototransduction was fitted to the leading edge of the a-waves of these ERGs. Nearly all patients showed an abnormally low sensitivity of cone phototransduction consistent with a reduction in the amplification of transduction. This abnormality can account for part of the delayed 30 Hz response. Analysis of post-receptoral potentials indicated that RP also slows the responses of the inner retina. A combination of these two factors, a sensitivity change at the receptor and a delay in the response of the inner retina, produces the delayed response of the cone flicker ERG in patients with RP.
journal_name
Vision Resjournal_title
Vision researchauthors
Hood DC,Birch DGdoi
10.1016/0042-6989(95)00246-4subject
Has Abstractpub_date
1996-06-01 00:00:00pages
1699-709issue
11eissn
0042-6989issn
1878-5646pii
0042-6989(95)00246-4journal_volume
36pub_type
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