Abstract:
:Total synthetic studies on natural products with promising biological profiles, coupled with their intriguing structural features, are described. The target molecules dealt with in this article are five helianane-type sesquiterpenes (heliannuols A, D and K and heliespirones A and C) and three meroterpenes (breviones A, B and C) with allelopathic activity, as well as four cytotoxic polyketides (lasonolide A and aspergillides A, B and C) and two pyrrolidinoindoline alkaloids (physostigmine and psychotrimine) with acetylcholine esterase inhibitory and antibacterial activities.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Shishido Kdoi
10.1248/cpb.c13-00417subject
Has Abstractpub_date
2013-01-01 00:00:00pages
781-98issue
8eissn
0009-2363issn
1347-5223pii
DN/JST.JSTAGE/cpb/c13-00417journal_volume
61pub_type
杂志文章,评审abstract::Structural optimization of 2-aminonicotinamide derivatives as ghrelin receptor inverse agonists is reported. So as to avoid mechanism-based inactivation (MBI) of CYP3A4, 1,3-benzodioxol ring of the lead compound was modified. Improvement of the main activity and lipophilicity was achieved simultaneously, leading to co...
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