Abstract:
:Green tea and (-)-epigallocatechin gallate (EGCG: one of main components of green tea) are well known to have preventive activities against human cancers. Previously, using a galloyl group as a core structure derived from EGCG, we developed alkyl gallate and gallamide derivatives, which showed strong antiproliferative activity towards human leukemia HL-60 cells by inducing apoptosis. Here, as a further structural development study, we planned to introduce an additional galloyl group into alkyl gallates and gallamides. According to this strategy, various bisgallate and bisgallamide derivatives were synthesized and tested for antiproliferative activity towards HL-60 cells. In gallamide derivatives having a short alkyl chain, the additional galloyl group enhanced the antiproliferative activity. In contrast, in the gallate derivatives, the additional galloyl group had no effect on the antiproliferative activity.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Dodo K,Minato T,Hashimoto Ydoi
10.1248/cpb.57.190subject
Has Abstractpub_date
2009-02-01 00:00:00pages
190-4issue
2eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/57.190journal_volume
57pub_type
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journal_title:Chemical & pharmaceutical bulletin
pub_type: 杂志文章
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