Abstract:
:Fourteen new bisnor- and norditerpene dilactones, makilactones E-R, having a 7alpha : 8alpha-epoxy-9,11-enolide substructure, were isolated from a methanolic extract of the root and the bark of Podocarpus macrophyllus D. DON (Podocarpaceae) with thirteen known bisnor- and norditerpenoids, and the structures of those new bisnor- and norditerpenoids were determined on the basis of their spectroscopic studies. Of the thirteen known ones isolated, the structures of two, i.e., podolactone B and inumakilactone B, were revised on the basis of X-ray crystallographic analysis and spectroscopic analysis. Many of the compounds of this type isolated in this study showed potent cytotoxic activities against P388 murine leukemia cells.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Sato K,Inaba Y,Park HS,Akiyama T,Koyama T,Fukaya H,Aoyagi Y,Takeya Kdoi
10.1248/cpb.57.668subject
Has Abstractpub_date
2009-07-01 00:00:00pages
668-79issue
7eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/57.668journal_volume
57pub_type
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