Severe hypertension and cardiac failure associated with neuroblastoma: a case report.

Abstract:

:The authors report on 3-year-old-girl with neuroblastoma complicated by severe hypertension and cardiac failure. She had cardiomegaly and pleural and pericardial effusions. Echocardiogram showed left ventricular hypertrophy and decrease of the left ventricular ejection fraction to 0.36 (normal > .40). Abdominal computed tomographic scan indicated a 7 x 7-cm tumor in the left suprarenal area. There was a marked increase in catecholamines and metabolites in her body fluids. After hypertension was controlled with doxazosin (a long-acting alpha 1 adrenergic blocker), her cardiac function gradually improved. A tumor was surgically removed and diagnosed as a poorly differentiated ganglioneuroblastoma. Preoperative differentiation between neuroblastoma and pheochromocytoma was not possible on the basis of catecholamine analysis or imaging studies including computed tomography scan and magnetic resonance imaging. It is important to control hypertension quickly in the patients with catecholamine-induced cardiomyopathy to facilitate surgical intervention for diagnosis and treatment.

journal_name

J Pediatr Surg

authors

Sendo D,Katsuura M,Akiba K,Yokoyama S,Tanabe S,Wakabayashi T,Sato S,Otaki S,Obata K,Yamagiwa I,Hayasaka K

doi

10.1016/s0022-3468(96)90051-2

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

1688-90

issue

12

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(96)90051-2

journal_volume

31

pub_type

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