Indium 111 oxine-labeled leukocytes for early diagnosis of ischemic enterocolitis.


:The feasibility of the use of indium 111 oxine-labeled autologous leukocytes for the diagnosis of ischemic enterocolitis in vivo was examined in an experimental model of ischemia in dogs. A 30-cm segment of small intestine was devascularized by ligating the arteries and veins from the last arcade in 7 dogs. A sham operation was performed in 3 control dogs. 111In oxine-labeled autologous white blood cells were infused 3.5 hours after operation. Anterior and lateral nuclear scanning was performed at 6 and 24 hours postinfusion with a gamma camera equipped with a low-energy magnifying multihole collimator. The animals were killed after 24 hours. The gross and microscopic appearance of the bowel was evaluated. The radioactivity in the serial specimens of the bowel was measured. In vivo scans were positive (ie, increased uptake in the bowel loop) in all dogs with intestinal ischemia at 6 and 24 hours. No significant uptake was noted in control dogs. Rectilinear scan of the bowel removed at autopsy showed a correlation between the area of infarction and tracer accumulation. In addition, there was a progressive decrease in uptake of 111In oxine from the center of the ischemic lesions to the periphery. Forty percent of the total radioactivity was measured at the center of the lesion, whereas only 6.5% was present at 22.5 cm from the center. Thus the ratio between the ischemic and normal tissue was 10:1 (range, 6.5 to 16). These studies demonstrate that 111In oxine-labeled autologous white blood cells can be used for the diagnosis of ischemic enterocolitis.(ABSTRACT TRUNCATED AT 250 WORDS)


J Pediatr Surg


De Agustin J,Kalhan S,Grisoni E




Has Abstract


1991-09-01 00:00:00














  • Comparative analysis of successful and unsuccessful candidates for the pediatric surgical matching program.

    abstract::Only one third of the applicants for training in pediatric surgery obtain a position through the pediatric surgery matching program. In order to identify factors that contribute to a successful outcome, we conducted a retrospective survey of all participants in the matching process for positions during the years 1983 ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Hirthler MA,Glick PL,Hassett JM Jr,Rossman J,Mendola P,Allen JE,Jewett TC Jr,Cooney DR

    更新日期:1992-02-01 00:00:00

  • Diamond-shaped anastomosis for duodenal atresia: an experience with 44 patients over 15 years.

    abstract::During the period between 1974 and 1988 44 patients were treated for congenital intrinsic duodenal obstruction using a diamond-shaped anastomosis (35 atresias, including two multiple atresias and nine stenoses). Neither gastrostomy nor transanastomotic tube was used. Postoperatively, oral feeding was started on days 2...

    journal_title:Journal of pediatric surgery

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    authors: Kimura K,Mukohara N,Nishijima E,Muraji T,Tsugawa C,Matsumoto Y

    更新日期:1990-09-01 00:00:00

  • Use of angioembolization as an effective technique for the management of pediatric solid tumors.

    abstract:PURPOSE:In oncology practice, angioembolization has been reported for tumor reduction before surgery, treatment of life-threatening conditions, and for palliative care. Nevertheless, the overall experience with angioembolization for the treatment of tumors is limited. We report our experience in 7 nonvascular solid ped...

    journal_title:Journal of pediatric surgery

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    authors: Krauel L,Albert A,Mora J,Sola T,Cruz O,Mortera C,Ribó JM

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    journal_title:Journal of pediatric surgery

    pub_type: 临床试验,杂志文章


    authors: Leppert A,Nadalin S,Schirg E,Petersen C,Kardorff R,Galanski M,Fuchs J

    更新日期:2002-10-01 00:00:00

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Matalon SV,Ewald RG,Hunt CE,Leonard AS

    更新日期:1976-12-01 00:00:00

  • Vascular control for resection of suprahepatic intracaval Wilms' tumor: technical considerations.

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    journal_title:Journal of pediatric surgery

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    authors: Lodge AJ,Jaggers J,Adams D,Rice HE

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    journal_title:Journal of pediatric surgery

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    authors: Kobayashi H,Yamataka A,Lane GJ,Miyano T

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    journal_title:Journal of pediatric surgery

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    journal_title:Journal of pediatric surgery

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    journal_title:Journal of pediatric surgery

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    authors: Lee SC,Chun YS,Jung SE,Park KW,Kim WK

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Sapin E,Mahieu D,Borgnon J,Douvier S,Carricaburu E,Sagot P

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Prabhakar AR,Rai KK,Bedi S

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    journal_title:Journal of pediatric surgery

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    更新日期:2004-06-01 00:00:00

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    authors: Vachharajani AJ,Shah JK,Paes BA

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  • Thoracic gunshot wounds in children under 17 years of age.

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Tuggle DW,Perkins TA,Tunell WP

    更新日期:1989-07-01 00:00:00

  • Combined antenatal thyrotropin-releasing hormone and low-dose glucocorticoid therapy improves the pulmonary biochemical immaturity in congenital diaphragmatic hernia.

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    journal_title:Journal of pediatric surgery

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    authors: Suen HC,Losty P,Donahoe PK,Schnitzer JJ

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    authors: Dickinson EC,Tuncer R,Nadler EP,Koltuksuz U,Boyle P,Alber SM,Watkins SC,Ford HR

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Ein SH,Shandling B,Williams WG,Trusler G

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


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