Bone marrow biopsy in myelodysplastic syndromes: morphological characteristics and contribution to the study of prognostic factors.

abstract：:We present the rare occurrence of an inhibitor of factor VIII procoagulant arising in a patient with mild haemophilia A and rheumatoid arthritis. The inhibitor was transient and behaved like a low titre, type II factor VIII procoagulant inhibitor similar to previously reported cases (Biggs et al, 1972b). In vitro stud...

journal_title：British journal of haematology

authors： Bovill EG,Burns SL,Golden EA

更新日期：1985-10-01 00:00:00

abstract：:Primary familial and congenital polycythaemia (PFCP) is a disease characterized by increased red blood cell mass, and can be associated with mutations in the intracellular region of the erythropoietin (EPO) receptor (EPOR). Here we explore the mechanisms by which EPOR mutations induce PFCP, using an experimental syste...

journal_title：British journal of haematology

authors： Gross M,Ben-Califa N,McMullin MF,Percy MJ,Bento C,Cario H,Minkov M,Neumann D

更新日期：2014-05-01 00:00:00

abstract：:Clonal heterogeneity in multisited or recurrent lymphoid neoplasms is a phenomenon that has been increasingly studied in recent years. However, in mucosa-associated lymphoid tissue (MALT) lymphomas it remains largely unexplored. Patients diagnosed at our institution with multisited MALT lymphoma, from January 2009 to ...

journal_title：British journal of haematology

authors： Condom M,Climent F,Fernández D,Colomer D,Lopez-Guerra M,Varela M,Carro I,Maluquer C,Mercadal S,Oliveira AC,Pané M,Matias-Guiu X,González-Barca E,Sureda A,Domingo-Domenech E

更新日期：2020-05-23 00:00:00

abstract：:The recent advent of an improved commercial serum enzyme-linked immunosorbent assay (ELISA) for the detection of circulating galactomannan (GM), a major constituent of Aspergillus cell walls, has contributed to the diagnosis of invasive aspergillosis (IA) in many haematology and transplant centres. However, the optima...

journal_title：British journal of haematology

authors： Maertens J,Theunissen K,Verbeken E,Lagrou K,Verhaegen J,Boogaerts M,Eldere JV

更新日期：2004-09-01 00:00:00

abstract：:Immunohistochemistry of acute leukaemias in bone-marrow paraffin sections is commonly thought to be useless because of the poor preservation of many lineage-related markers. The recent development of antibodies against fixative-resistant epitopes and of new antigen retrieval techniques, however, has expanded the possi...

journal_title：British journal of haematology

authors： Pileri SA,Ascani S,Milani M,Visani G,Piccioli M,Orcioni GF,Poggi S,Sabattini E,Santini D,Falini B

更新日期：1999-05-01 00:00:00

abstract：:Increased haemoglobin (Hb) A2 levels associated with reduced mean corpuscular volume (MCV) and Hb content per cell (MCH) are the most typical features of heterozygous beta thalassaemia. However, double heterozygotes for alpha and beta thalassaemia may have normal MCV and MCH but Hb A2 always in the carrier range. In t...

journal_title：British journal of haematology

authors： Gasperini D,Cao A,Paderi L,Barella S,Paglietti E,Perseu L,Loi D,Galanello R

更新日期：1993-05-01 00:00:00

abstract：:An unusual variant of congenital dyserythropoietic anaemia is described presenting as mild haemolytic anaemia with multinucleated erythroblasts in the marrow of the proband. The outcome of her non-consanguineous pregnancy was a third trimester, in utero, fetal demise. The hydropic fetus had dyserythropoiesis with circ...

journal_title：British journal of haematology

authors： Roberts DJ,Nadel A,Lage J,Rutherford CJ

更新日期：1993-07-01 00:00:00

abstract：:Patients with multiple myeloma (MM) undergoing high dose therapy and autologous stem cell transplantation (SCT) remain at risk for disease progression. Induction of the expression of highly immunogenic cancer testis antigens (CTA) in malignant plasma cells in MM patients may trigger a protective immune response follow...

journal_title：British journal of haematology

authors： Toor AA,Payne KK,Chung HM,Sabo RT,Hazlett AF,Kmieciak M,Sanford K,Williams DC,Clark WB,Roberts CH,McCarty JM,Manjili MH

更新日期：2012-09-01 00:00:00

abstract：:Two cases of Ph1-positive chronic granulocytic leukaemia with hitherto undescribed translocations are presented. In case 1 the deleted part of chromosome number 22q- was translocated to the short arm of the X chromosome, t(X;22)(p22;q11). Pronounced basophilia, trisomy 19 in the majority of metaphases, and a partial c...

journal_title：British journal of haematology

authors： Hossfeld DK,Köhler S

更新日期：1979-02-01 00:00:00

abstract：:The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lympho...

journal_title：British journal of haematology

authors： Miyamura T,Moritake H,Nakayama H,Tanaka S,Tomizawa D,Shiba N,Saito AM,Tawa A,Shimada A,Iwamoto S,Hayashi Y,Koike T,Horibe K,Manabe A,Mizutani S,Taga T,Adachi S

更新日期：2019-04-01 00:00:00

abstract：:We have investigated the kinetics of colony formation by progenitor cells in chronic myeloid leukaemia (CML) using erythroid burst-forming units (BFU-E) as a model system. For this, we scored the numbers of subcolonies produced by individual BFU-E in cultures of normal marrow and blood cells and in cultures of CML blo...

journal_title：British journal of haematology

authors： Marley SB,Lewis JL,Goldman JM,Gordon MY

更新日期：1996-06-01 00:00:00

abstract：:Leucocyte alkaline phosphatase (LAP) is a marker of post-mitotic granulocytes and its activity is reduced or absent in chronic myelogenous leukaemia (CML) granulocytes as a consequence of LAP messenger RNA (mRNA) deficiency. We provide evidence that along the granulocytic maturation in normal marrow, the acquisition o...

journal_title：British journal of haematology

authors： Dotti G,Garattini E,Borleri G,Masuhara K,Spinelli O,Barbui T,Rambaldi A

更新日期：1999-04-01 00:00:00

abstract：:The in vitro and in vivo activity of a deoxycytidine analogue, troxacitabine, alone or in combination with imatinib mesylate (IM), was evaluated against human chronic myeloid leukaemia (CML) cell lines both sensitive (KBM5 and KBM7) and resistant (KBM5-R and KBM7-R) to IM. These cell lines differ in their sensitivity ...

journal_title：British journal of haematology

authors： Orsolic N,Giles FJ,Gourdeau H,Golemovic M,Beran M,Cortes J,Freireich EJ,Kantarjian H,Verstovsek S

更新日期：2004-03-01 00:00:00

abstract：:The transport of iron through erythroid cell membrane was studied in a model system, measuring ferrous iron uptake by reticulocytes. It was found that these cells were able to take up ferrous iron and to incorporate it into haem at a rate similar to that observed when diferric transferrin was the iron donor. No compar...

journal_title：British journal of haematology

authors： Egyed A

更新日期：1988-04-01 00:00:00

abstract：:We report our long-term experience with autologous bone marrow transplantation (ABMT) for 32 adult patients with acute lymphocytic leukaemia (ALL) in second or later remission (CR), or in first CR but with high-risk. Bone marrow was purged with mafosfamide (n = 25) or with immunomagnetic beads and monoclonal antibodie...

journal_title：British journal of haematology

authors： Abdallah A,Egerer G,Goldschmidt H,Wannenmacher M,Körbling M,Ho AD

更新日期：2001-03-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) were recently demonstrated to exist in human cord blood. Phytohaemagglutinin (PHA), a potent mitogen for mononuclear cells was used to induce EPCs from unsorted cord blood mononuclear cells (CBMCs). Adherent cells in clusters appeared approximately 24 h after CBMCs were cultured in ...

journal_title：British journal of haematology

authors： Kang HJ,Kim SC,Kim YJ,Kim CW,Kim JG,Ahn HS,Park SI,Jung MH,Choi BC,Kimm K

更新日期：2001-06-01 00:00:00

abstract：:Heterozygosity for a C8524T transition in the protein C gene converting Ser270(TCG) to Leu(TTG) in the protease domain was identified in a family with venous thrombosis. The mutation was associated with parallel reduction in plasma levels of protein C anticoagulant activity and protein C antigen, which is consistent w...

journal_title：British journal of haematology

authors： Lind B,Koefoed P,Thorsen S

更新日期：2001-06-01 00:00:00

abstract：:Multiple myeloma (MM) tumour cells evade host immunity through a variety of mechanisms, which may potentially include the programmed cell death ligand-1 (PD-L1):programmed cell death protein-1 (PD-1) axis. This interaction contributes to the immunosuppressive bone marrow (BM) microenvironment, ultimately leading to re...

journal_title：British journal of haematology

authors： Chen H,Li M,Ng N,Yu E,Bujarski S,Yin Z,Wen M,Hekmati T,Field D,Wang J,Nassir I,Yu J,Huang J,Daniely D,Wang CS,Xu N,Spektor TM,Berenson JR

更新日期：2020-12-20 00:00:00

abstract：:The 5th International Symposium on Childhood, Adolescent and Young Adult (CAYA) Non-Hodgkin Lymphoma (NHL) was held in Varese, Italy, from 21-25 October 2015. This review represents a summary of the scientific sessions of this international symposium including childhood, adolescent and young adult (AYA) NHL in countri...

journal_title：British journal of haematology

authors： Cairo MS,Pinkerton R

更新日期：2016-05-01 00:00:00

abstract：:Besides circulating in normal plasma, von Willebrand factor (VWF) is also stored at relatively high concentration within the alpha-granules of platelets. This pool of platelet VWF exists distinct from plasma VWF, and is enriched in haemostatically-active high molecular weight multimers. Interestingly, the glycosylatio...

journal_title：British journal of haematology

authors： McGrath RT,McRae E,Smith OP,O'Donnell JS

更新日期：2010-03-01 00:00:00

abstract：:Eight patients with aplastic anaemia associated with dyskeratosis congenita received allogeneic marrow grafts from either HLA-identical siblings (six patients) or HLA-matched unrelated donors (two patients). Patients who received marrow from HLA-identical siblings were conditioned with cyclophosphamide (140-200 mg/kg)...

journal_title：British journal of haematology

authors： Langston AA,Sanders JE,Deeg HJ,Crawford SW,Anasetti C,Sullivan KM,Flowers ME,Storb R

更新日期：1996-03-01 00:00:00

abstract：:The endothelial hybridoma (EAhy926) cell line was employed to clarify whether antiphospholipid antibodies (aPA) [lupus anticoagulant (LA), antiprothrombin antibody (aPT) and/or anticardiolipin antibody (aCL)] and anti-endothelial cell antibodies (AECA) are identical, and establish whether beta2-glycoprotein I (beta2-G...

journal_title：British journal of haematology

authors： Matsuda J,Gotoh M,Gohchi K,Kawasugi K,Tsukamoto M,Saitoh N

更新日期：1997-04-01 00:00:00

abstract：:The heterogeneity of pyruvate kinase (PK) deficiency associated with hereditary haemolytic anaemia is emphasized by studies of a kindred harbouring two distinct mutant forms of this enzyme, both of which were kinetically defective with markedly decreased affinities for the substrate, phosphoenolypyruvate. The two isoe...

journal_title：British journal of haematology

authors： Pagila DE,Gray GR,Growe GH,Valentine WN

更新日期：1976-09-01 00:00:00

abstract：:Peripheral blood haematopoietic progenitor cell mobilization has become a standard procedure prior to autologous stem cell transplantation. Biosimilar granulocyte colony-stimulating factors (GCSF) have recently been awarded European Union (EU) licences for stem cell mobilization but data for their use in this context ...

journal_title：British journal of haematology

authors： Publicover A,Richardson DS,Davies A,Hill KS,Hurlock C,Hutchins D,Jenner MW,Johnson PW,Lamb J,Launders H,McKeag N,Newman J,Orchard KH

更新日期：2013-07-01 00:00:00

abstract：:Marginal zone B-cell lymphoma (MZBCL) represents a distinct subtype of B-cell non-Hodgkin's lymphoma (NHL) which has been recently recognized and defined as a disease entity. Cytogenetically, these lymphomas reveal a high prevalence of trisomy 3, and recent data obtained by comparative genomic hybridization indicate t...

journal_title：British journal of haematology

authors： Dierlamm J,Pittaluga S,Stul M,Wlodarska I,Michaux L,Thomas J,Verhoef G,Verhest A,Depardieu C,Cassiman JJ,Hagemeijer A,De Wolf-Peeters C,Van den Berghe H

更新日期：1997-09-01 00:00:00

abstract：:In this study we show that in vitro cultured human polyclonal NK cell lines and clones express the Ki-1/CD30 Hodgkin-associated antigen, identified by the BER-H2 monoclonal antibody. The percentage of BER-H2+ cells ranged from 19% to 67% in five polyclonal NK cell lines and was 31% and 20% in two NK clones. The intens...

journal_title：British journal of haematology

authors： Cambiaggi A,Cantoni C,Marciano S,De Totero D,Pileri S,Tazzari PL,Stein H,Ferrini S

更新日期：1993-10-01 00:00:00

abstract：:Follicular lymphoma (FL) constitutes a significant proportion of lymphomas and shows frequent relapses. Beyond conventional chemotherapy, new therapeutic approaches have emerged, focussing on the interplay between lymphoma cells and the microenvironment. Here we report the immunophenotypic investigation of the microen...

journal_title：British journal of haematology

authors： Menter T,Tzankov A,Zucca E,Kimby E,Hultdin M,Sundström C,Beiske K,Cogliatti S,Banz Y,Cathomas G,Karjalainen-Lindsberg ML,Grobholz R,Mazzucchelli L,Sander B,Hawle H,Hayoz S,Dirnhofer S

更新日期：2020-05-01 00:00:00

abstract：:Serum erythropoietin (Epo) was measured in 23 patients before, during and after intensive cytostatic treatment courses for acute leukaemia or before bone marrow transplantation. A marked increase was seen in all patients, starting 1 or 2 d after initiation of treatment. A peak was reached after about 7 d, at levels as...

journal_title：British journal of haematology

authors： Birgegård G,Wide L,Simonsson B

更新日期：1989-07-01 00:00:00

abstract：:Human amniotic fluid has been shown to contain blood group i as well as I antigens. Crude extracts of amniotic fluids at 16-23 weeks of gestation were in general more active than those obtained at term. A pool of amniotic fluids which had A, B, H as well as I and i activity was fractionated with an insolubilized anti-...

journal_title：British journal of haematology

authors： Feizi T,Cederqvist LL,Childs R

更新日期：1975-08-01 00:00:00

abstract：:The proteasome inhibitor, bortezomib, potentially increases cell sensitivity to chemotherapy. This study was performed to determine the overall response rate (ORR), overall survival (OS), progression-free survival (PFS) and toxicity of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) compared to CHOP...

journal_title：British journal of haematology

authors： Furtado M,Johnson R,Kruger A,Turner D,Rule S

更新日期：2015-01-01 00:00:00