Abstract：
:Previous studies with octachlorodibenzo-p-dioxin (OCDD) and octachlorodibenzofuran (OCDF) in juvenile or adult fish exposed via water revealed no toxicity, despite significant bioaccumulation. With 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD), the fish early-life stage study has been shown to be the most sensitive test system. Therefore, the effects of OCDD and OCDF on the early-life stages of zebra fish (Brachydanio rerio) were determined during a flow-through test based on a column generator method. No statistically significant effect of OCDD and OCDF on the survival and hatching time of the eggs was found. Furthermore, no effects on survival, weight, general appearance or behaviour of the larvae were observed at the end of the exposure period of 32 days. GC-MS analysis of test solution samples revealed geometric mean measured concentrations of 32 (OCDD) and 34 ng/l (OCDF), respectively. Concentrations in surviving larvae at the end of the study were 61 (OCDD) and 94 (OCDF) micrograms/kg, respectively. These concentrations in zebra fish larvae were several orders of magnitude higher than concentrations in fish collected from the wild. In a review of the available laboratory fish experiments, we found a lack of biomagnification of OCDD and OCDF. We do not expect to find adverse effects of these compounds on the aquatic environment.
journal_name
Chemospherejournal_title
Chemosphereauthors
Berends AG,Boelhouwers EJ,Thus JL,de Gerlache J,de Rooij CGdoi
10.1016/s0045-6535(97)00129-xsubject
Has Abstractpub_date
1997-08-01 00:00:00pages
853-65issue
4eissn
0045-6535issn
1879-1298pii
S004565359700129Xjournal_volume
35pub_type
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