Abstract：
:Primary progressive aphasia (PPA) was first recognized by Mesulam in 1982. Although dozens of cases have since been described, it has been difficult to place these cases into a coherent framework due to the wide variation in measures which have been reported. We review 170 contacts with 112 patients to provide a clinical, neuroanatomical, and neuropsychological profile of patients with the disorder. The progression of the disease is analyzed over a 10-year reporting period starting from symptom onset to show how progression affects five general linguistic skills: oral and written naming, reading, repetition, and general comprehension. The pattern of functional and neurological deficits in PPA is heterogeneous. Differences in the distribution of neurological anomalies between patients with bilateral and unilateral changes suggest that there may be two separate disease processes involved.
journal_name
Brain Langjournal_title
Brain and languageauthors
Westbury C,Bub Ddoi
10.1006/brln.1997.1840subject
Has Abstractpub_date
1997-12-01 00:00:00pages
381-406issue
3eissn
0093-934Xissn
1090-2155pii
S0093-934X(97)91840-Xjournal_volume
60pub_type
杂志文章,评审abstract：:Experience-dependent enhancement of neural encoding of pitch in the auditory brainstem has been observed for only specific portions of native pitch contours exhibiting high rates of pitch acceleration, irrespective of speech or nonspeech contexts. This experiment allows us to determine whether this language-dependent ...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2010.05.004
更新日期：2010-09-01 00:00:00
abstract：:A speculative neuronal model for vowel normalization and representation is offered. The neurophysiological basis for the premise is the "combination-sensitive" neuron recently documented in the auditory cortex of the mustached bat (N. Suga, W. E. O'Neill, K. Kujirai, and T. Manabe, 1983, Journal of Neurophysiology, 49...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(86)90087-8
更新日期：1986-05-01 00:00:00
abstract：:Lexical processing has long been associated with left-hemisphere function, especially for infrequently occurring words. Recently, however, persons with severe aphasia, including word-recognition deficits, were observed to recognize familiar proper nouns. Further, some patients suffering right-hemisphere damage were po...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.2000.2365
更新日期：2001-05-01 00:00:00
abstract：:We report results of an experimental study with Dutch agrammatic aphasics that investigated their ability to interpret pronominal elements in transitive clauses and Exceptional Case Marking constructions (ECM). Using the obtained experimental results as a tool, we distinguish between three competing linguistic theorie...
journal_title：Brain and language
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.bandl.2005.06.005
更新日期：2006-03-01 00:00:00
abstract：:Debate continues regarding the necessary role of right superior temporal gyrus (STG) regions in sublexical speech perception given the bilateral STG activation often observed in fMRI studies. To evaluate the causal roles, TMS pulses were delivered to inhibit and disrupt neuronal activity at the left and right STG regi...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2020.104838
更新日期：2020-10-01 00:00:00
abstract：:This study investigated the hypothesis that the syntactic trees formed by individuals with agrammatic aphasia cannot be constructed any higher than an impaired node as suggested by the tree-pruning hypothesis (Friedman, 1994; Friedmann & Grodzinsky, 1997) and hypothesis. It also examined their following implication th...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/s0093-934x(02)00515-1
更新日期：2003-02-01 00:00:00
abstract：:A variety of experimental paradigms has yielded surprisingly fine-grained evidence about the kinds of syntactic information to which agrammatic aphasics are sensitive. This paper contrasts three accounts of agrammatism which draw quite different conclusions about the implications of this disorder for normal function: ...
journal_title：Brain and language
pub_type： 杂志文章,评审
doi：10.1006/brln.1995.1040
更新日期：1995-07-01 00:00:00
abstract：:In this paper we examine the tendency for agrammatic aphasics to make thematic reversal errors in comprehension, e.g., a tendency for English-speaking agrammatics to assign a preposed object the subject role. Although this tendency has been argued to follow from either a linear (Grodzinsky, 1995) or a directionality (...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.1998.1988
更新日期：1998-11-01 00:00:00
abstract：:The traditional clinical picture for English nonfluent aphasics has generally presented the deficit as one of total loss of control over grammatical morphology, with some sparing of word order. This is at odds with recent research involving nonfluent aphasic speakers of highly inflected languages, which has shown that...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(91)90156-u
更新日期：1991-08-01 00:00:00
abstract：:Vocal reaction times were measured in Italian dyslexics and in proficient readers while they read single words. Three groups of control participants (for a total of 79) were tested. All were in the first, second or third grade of elementary school. Nine third graders with a low level of reading ability when assessed b...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2004.10.010
更新日期：2005-06-01 00:00:00
abstract：:It has been known that lesions in the left inferior frontal gyrus (L. IFG) do not always cause Broca's aphasia, casting doubt upon the specificity of this region. We have previously devised a picture-sentence matching task for a functional magnetic resonance imaging (fMRI) study, and observed that both pars triangular...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2009.05.001
更新日期：2009-08-01 00:00:00
abstract：:It is controversial as to how age of acquisition (AoA) and proficiency level of the second language influence the similarities and differences between the first (L1) and the second (L2) language brain networks. In this functional MRI study, we used representational similarity analysis to quantify the degree of neural ...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2019.104740
更新日期：2020-04-01 00:00:00
abstract：:Gestural communication is a modality considered in the literature as a candidate for determining the ancestral prerequisites of the emergence of human language. As reported in captive chimpanzees and human children, a study in captive baboons revealed that a communicative gesture elicits stronger degree of right-hand ...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2008.10.004
更新日期：2009-03-01 00:00:00
abstract：:The goal of the present research was to provide direct evidence for the cross-language interaction of phonologies at the sub-lexical level by using the masked onset priming paradigm. More specifically, we investigated whether there is a cross-language masked onset priming effect (MOPE) with L2 (English) primes and L1 ...
journal_title：Brain and language
pub_type： 临床试验,杂志文章
doi：10.1016/j.bandl.2014.04.003
更新日期：2014-07-01 00:00:00
abstract：:A well-known feature of Broca's aphasia is the problem of handling "small words." It has been claimed that patients show these problems in both language production and language perception. The traditional dichotomy of "function" words and "content" words is probably not a good description of the classes of words that ...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(86)90110-0
更新日期：1986-07-01 00:00:00
abstract：:The current study addresses the debate between so-called 'structural' and 'processing limitation' accounts of aphasia, i.e., whether language impairments reflect the 'loss' of linguistic knowledge or its representations, or instead reflect a limitation in processing resources. Confrontation-naming task and category-ju...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2004.06.002
更新日期：2005-02-01 00:00:00
abstract：:Does age constrain the outcome of all language acquisition equally regardless of whether the language is a first or second one? To test this hypothesis, the English grammatical abilities of deaf and hearing adults who either did or did not have linguistic experience (spoken or signed) during early childhood were inves...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/s0093-934x(03)00137-8
更新日期：2003-12-01 00:00:00
abstract：:Children with congenital left hemisphere damage due to perinatal stroke are capable of acquiring relatively normal language functions despite experiencing a cortical insult that in adults often leads to devastating lifetime disabilities. Although this observed phenomenon is accepted, its neurobiological mechanisms are...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2009.09.001
更新日期：2010-08-01 00:00:00
abstract：:Previous studies suggest that anatomical anomalies [Foundas, A. L., Bollich, A. M., Corey, D. M., Hurley, M., & Heilman, K. M. (2001). Anomalous anatomy of speech-language areas in adults with persistent developmental stuttering. Neurology, 57, 207-215; Foundas, A. L., Corey, D. M., Angeles, V., Bollich, A. M., Crabtr...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2007.04.005
更新日期：2008-02-01 00:00:00
abstract：:The role of attentional control in lexical ambiguity resolution was examined in two patients with damage to the left inferior frontal gyrus (LIFG) and one control patient with non-LIFG damage. Experiment 1 confirmed that the LIFG patients had attentional control deficits compared to normal controls while the non-LIFG ...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2010.09.012
更新日期：2011-01-01 00:00:00
abstract：:Although very young children seem to process ongoing language quickly and effortlessly, neuroimaging and behavioral studies reveal that children continue to mature in their language skills through adolescence. During this prolonged development, children likely engage the same basic cognitive processes and neural mecha...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2018.09.002
更新日期：2018-11-01 00:00:00
abstract：:Subjects were asked to indicate which item of a word/nonword pair was a word. On critical trials the nonword was a pseudohomophone of the word. RTs of dyslexics were shorter in blocks of trials in which a congruent auditory prime was simultaneously presented with the visual stimuli. RTs of normal readers were longer f...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.1998.1996
更新日期：1999-02-01 00:00:00
abstract：:Explicit associative-semantic processing of words and pictures activates a distributed set of brain areas that has been replicated across a wide range of studies. We applied graph analysis to examine the structure of this network. We determined how the left ventral occipitotemporal transition zone (vOT) was connected ...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2012.09.005
更新日期：2013-11-01 00:00:00
abstract：:We used fMRI to examine patterns of brain activity associated with component processes of visual word recognition and their relationships to individual differences in reading skill. We manipulated both the judgments adults made on written stimuli and the characteristics of the stimuli. Phonological processing led to a...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2011.12.011
更新日期：2012-03-01 00:00:00
abstract：:Two cases of acquired spelling dyslexia and one case of developmental spelling dyslexia are described along with accounts of their performance on various psycholinguistic tasks. It is argued that there is some evidence that spelling dyslexia may exist in developmental form but that parallels are difficult to draw beca...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(83)90045-7
更新日期：1983-11-01 00:00:00
abstract：:We report an experiment that evaluates whether BLANK or an unrelated prime is a more suitable baseline for assessing priming for an ERP study. Sixteen subjects performed a lexical decision task with a 1 s prime-target stimulus onset asynchrony. Increased amplitude for the N400 was observed for targets in the unrelated...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2005.08.002
更新日期：2006-04-01 00:00:00
abstract：:Does "the motor system" play "a role" in speech perception? If so, where, how, and when? We conducted a systematic review that addresses these questions using both qualitative and quantitative methods. The qualitative review of behavioural, computational modelling, non-human animal, brain damage/disorder, electrical s...
journal_title：Brain and language
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.bandl.2016.10.004
更新日期：2017-01-01 00:00:00
abstract：:Relatively few studies have analyzed the mechanisms underlying the cognitive changes that affect language in the elderly, and fewer have done so for narrative discourse. The goal of this study was to explore the neurofunctional changes associated with aging for different components of narrative discourse. Functional n...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2011.09.008
更新日期：2012-05-01 00:00:00
abstract：:In this special issue of Brain and Language, we examine what implications the division between the left and the right brain half has for the recognition of words presented in the center of the visual field. The different articles are a first indication that taking into account the split between the left and the right ...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/S0093-934X(03)00279-7
更新日期：2004-03-01 00:00:00
abstract：:The syllable has received considerable empirical support as a unit of processing in speech perception, but its status in speech production remains unclear. Some researchers propose that syllables are individually represented and retrieved during phonological encoding (e.g., Dell, 1986; Ferrand, Segui, & Grainger, 1996...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/s0093-934x(02)00501-1
更新日期：2003-03-01 00:00:00
