当前位置： SCI文献检索 > NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS期刊下所有文献 > Meta-analysis of functional network alterations in Alzheimer's disease: toward a network biomarker.

Meta-analysis of functional network alterations in Alzheimer's disease: toward a network biomarker.

Abstract：

:The increasing prevalence of Alzheimer's disease (AD) emphasizes the need for sensitive biomarkers. Memory, a core deficit in AD, involves the interaction of distributed brain networks. We propose that biomarkers should be sought at the level of disease-specific disturbances in large-scale neural networks instead of alterations in a single brain region. This is the first voxel-level quantitative meta-analysis of default mode connectivity and task-related activation in 1196 patients and 1255 controls to detect robust changes in components of large-scale neural networks. We show that with disease progression, specific components of networks are widespread altered. The medial parietal regions and the subcortical areas are differentially affected depending on the disease stage. Specific compensatory mechanisms are only seen in the earliest stages, before symptoms are evident, and could become a functional network biomarker or target for interventions. These results underline the need to further fine-grain these networks spatially and temporally across disease stages. To conclude, AD should indeed be considered as a syndrome involving neural network disruption before cognitive deficits are detectable.

journal_name

Neurosci Biobehav Rev

journal_title

Neuroscience and biobehavioral reviews

authors

Jacobs HI,Radua J,Lückmann HC,Sack AT

doi

10.1016/j.neubiorev.2013.03.009

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

753-65

issue

5

eissn

0149-7634

issn

1873-7528

pii

S0149-7634(13)00069-9

journal_volume

37

pub_type

杂志文章,meta分析,评审

相关文献

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS文献大全
  • The relationship between reinforcement and memory: parallels in the rewarding and mnemonic effects of the neuropeptide substance P.

    abstract：:A theory of reinforcement is presented which accounts for the backward action of a reinforcer on operant behavior in terms of its effect on memory traces left by the operant. Several possible ways in which a reinforcer could strengthen the probability of recurrence of an operant are discussed. Predictions from the mod...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/s0149-7634(89)80027-2

    authors： Huston JP,Oitzl MS

    更新日期：1989-07-01 00:00:00

  • Understanding heterogeneity in conduct disorder: A review of psychophysiological studies.

    abstract：:The present review is concerned with the role of different physiological systems (e.g., skin conductance, heart rate, electromyography, and the eye-bling startle reflex) in understanding heterogeneity in conduct disorder (CD). Four subtyping approaches are considered: age of onset, comorbid psychopathology, callous-un...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2016.09.022

    authors： Fanti KA

    更新日期：2018-08-01 00:00:00

  • Functional imaging studies of dopamine system and cognition in normal aging and Parkinson's disease.

    abstract：:Modern functional imaging methods, such as positron emission tomography (PET) and single photon emission computed tomography (SPECT), provide non-invasive, quantitative tools for the direct measurement of neurotransmitter function in the living human brain. The dopamine system has been of key interest; first, because ...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/s0149-7634(02)00065-9

    authors： Kaasinen V,Rinne JO

    更新日期：2002-11-01 00:00:00

  • Commentary on the special issue on the adolescent brain: Adolescence, trajectories, and the importance of prevention.

    abstract：:Adolescence as highlighted in this special issue is a period of tremendous growth, synaptic exuberance, and plasticity, but also a period for the emergence of mental illness and addiction. This commentary aims to stimulate research on prevention science to reduce the impact of early life events that often manifest dur...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章

    doi：10.1016/j.neubiorev.2016.07.012

    authors： Andersen SL

    更新日期：2016-11-01 00:00:00

  • Effects of pre-natal alcohol exposure on hippocampal synaptic plasticity: Sex, age and methodological considerations.

    abstract：:The consumption of alcohol during gestation is detrimental to the developing central nervous system (CNS). The severity of structural and functional brain alterations associated with alcohol intake depends on many factors including the timing and duration of alcohol consumption. The hippocampal formation, a brain regi...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2016.02.014

    authors： Fontaine CJ,Patten AR,Sickmann HM,Helfer JL,Christie BR

    更新日期：2016-05-01 00:00:00

  • Pretreatment biomarkers predicting PTSD psychotherapy outcomes: A systematic review.

    abstract：:Although our understanding of the relationship between posttraumatic stress disorder (PTSD), brain structure and function, neural networks, stress-related systems, and genetics is growing, there is considerably less attention given to which biological markers predict evidence-based PTSD psychotherapy outcomes. Our sys...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2017.01.027

    authors： Colvonen PJ,Glassman LH,Crocker LD,Buttner MM,Orff H,Schiehser DM,Norman SB,Afari N

    更新日期：2017-04-01 00:00:00

  • Association between asymptomatic carotid stenosis and cognitive function: a systematic review.

    abstract：BACKGROUND:Asymptomatic carotid stenosis (CS), traditionally considered clinically silent, may be an independent risk factor for a cognitive impairment. METHODS:To determine whether an association exists between asymptomatic CS and cognitive function, we systematically reviewed the literature in the Cochrane Library, ...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2013.05.011

    authors： Chang XL,Zhou HQ,Lei CY,Wu B,Chen YC,Hao ZL,Dong W,Liu M

    更新日期：2013-09-01 00:00:00

  • The search for neuroimaging and cognitive endophenotypes: A critical systematic review of studies involving unaffected first-degree relatives of individuals with bipolar disorder.

    abstract：:The phenomenology and underlying pathophysiology of bipolar disorder (BD) are heterogeneous. The identification of putative endophenotypes for BD can aid in the investigation of unique patho-etiological pathways, which may lead to the development of personalised preventative and therapeutic approaches for this multi-f...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2016.12.011

    authors： Miskowiak KW,Kjærstad HL,Meluken I,Petersen JZ,Maciel BR,Köhler CA,Vinberg M,Kessing LV,Carvalho AF

    更新日期：2017-02-01 00:00:00

  • Crossmodal links in endogenous and exogenous spatial attention: evidence from event-related brain potential studies.

    abstract：:The adaptive control of behaviour in response to relevant external objects and events often requires the selection of information delivered by different sensory systems, but from the same region in external space. This can be facilitated by crossmodal links in the attentional processing of information across sensory m...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/s0149-7634(01)00029-x

    authors： Eimer M,Driver J

    更新日期：2001-08-01 00:00:00

  • Neural correlates of emotion-attention interactions: From perception, learning, and memory to social cognition, individual differences, and training interventions.

    abstract：:Due to their ability to capture attention, emotional stimuli tend to benefit from enhanced perceptual processing, which can be helpful when such stimuli are task-relevant but hindering when they are task-irrelevant. Altered emotion-attention interactions have been associated with symptoms of affective disturbances, an...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2019.08.017

    authors： Dolcos F,Katsumi Y,Moore M,Berggren N,de Gelder B,Derakshan N,Hamm AO,Koster EHW,Ladouceur CD,Okon-Singer H,Pegna AJ,Richter T,Schweizer S,Van den Stock J,Ventura-Bort C,Weymar M,Dolcos S

    更新日期：2020-01-01 00:00:00

  • The hierarchical basis of neurovisceral integration.

    abstract：:The neurovisceral integration (NVI) model was originally proposed to account for observed relationships between peripheral physiology, cognitive performance, and emotional/physical health. This model has also garnered a considerable amount of empirical support, largely from studies examining cardiac vagal control. How...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2017.02.003

    authors： Smith R,Thayer JF,Khalsa SS,Lane RD

    更新日期：2017-04-01 00:00:00

  • Neurobehavioral evidence for changes in dopamine system activity during adolescence.

    abstract：:Human adolescence has been characterized by increases in risk-taking, emotional lability, and deficient patterns of behavioral regulation. These behaviors have often been attributed to changes in brain structure that occur during this developmental period, notably alterations in gray and white matter that impact synap...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2009.12.007

    authors： Wahlstrom D,White T,Luciana M

    更新日期：2010-04-01 00:00:00

  • Will testing for apolipoprotein E assist in tailoring dementia risk reduction? A review.

    abstract：:This paper aims to systematically review the influence of apolipoprotein E (ApoE) on the effects of potentially modifiable mid and late life risk factors for dementia. Scopus, Medline, PubMed, PsycINFO, and HuGE databases were searched up to November 2008. Two independent reviewers selected 94 articles from 13,122 res...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2009.08.007

    authors： Low LF,Yap MH,Brodaty H

    更新日期：2010-03-01 00:00:00

  • Lateralization of brain mechanisms underlying automatic and controlled forms of spatial orienting of attention.

    abstract：:Unilateral Spatial Neglect (USN) can be considered as a defect in spatial orienting of attention toward the half space contralateral to the damaged hemisphere. Since the classical work of Brain, W.R. Brain 64:224-272 (1941), several authors have emphasized that this defect is definitely more frequent and severe in pat...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/0149-7634(95)00074-7

    authors： Gainotti G

    更新日期：1996-01-01 00:00:00

  • Conflicting emergences. Weak vs. strong emergence for the modelling of brain function.

    abstract：:The concept of "emergence" has become commonplace in the modelling of complex systems, both natural and man-made; a functional property" emerges" from a system when it cannot be readily explained by the properties of the system's sub-units. A bewildering array of adaptive and sophisticated behaviours can be observed f...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2019.01.023

    authors： Turkheimer FE,Hellyer P,Kehagia AA,Expert P,Lord LD,Vohryzek J,De Faria Dafflon J,Brammer M,Leech R

    更新日期：2019-04-01 00:00:00

  • Is subcortical-cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach.

    abstract：:Major depressive disorder has recently been characterized by abnormal resting state hyperactivity in anterior midline regions. The neurochemical mechanisms underlying resting state hyperactivity remain unclear. Since animal studies provide an opportunity to investigate subcortical regions and neurochemical mechanisms ...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.neubiorev.2009.11.023

    authors： Alcaro A,Panksepp J,Witczak J,Hayes DJ,Northoff G

    更新日期：2010-03-01 00:00:00

  • Animal models of mental retardation: from gene to cognitive function.

    abstract：:About 2-3% of all children are affected by mental retardation, and genetic conditions rank among the leading causes of mental retardation. Alterations in the information encoded by genes that regulate critical steps of brain development can disrupt the normal course of development, and have profound consequences on me...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/s0149-7634(03)00016-2

    authors： Branchi I,Bichler Z,Berger-Sweeney J,Ricceri L

    更新日期：2003-01-01 00:00:00

  • The socially stressed heart. Insights from studies in rodents.

    abstract：:The existence of a close relationship between psychosocial factors and cardiovascular morbidity is not just a hypothesis anymore. Research on humans has been attempting to unravel the significance of this association by investigating psychological and social characteristics in relation to cardiovascular health. Howeve...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2013.12.005

    authors： Sgoifo A,Carnevali L,Grippo AJ

    更新日期：2014-02-01 00:00:00

  • The neurobiology of thalamic amnesia: Contributions of medial thalamus and prefrontal cortex to delayed conditional discrimination.

    abstract：:Although medial thalamus is well established as a site of pathology associated with global amnesia, there is uncertainty about which structures are critical and how they affect memory function. Evidence from human and animal research suggests that damage to the mammillothalamic tract and the anterior, mediodorsal (MD)...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2015.01.011

    authors： Mair RG,Miller RL,Wormwood BA,Francoeur MJ,Onos KD,Gibson BM

    更新日期：2015-07-01 00:00:00

  • Pharmacogenetic and optical dissection for mechanistic understanding of Parkinson's disease: potential utilities revealed through behavioural assessment.

    abstract：:The technology toolbox by which neural elements can be selectively manipulated in vertebrate and invertebrate brains has expanded greatly in recent years, to now include sophisticated optogenetics and novel designer receptors. Application of such tools allow for ascertaining whether a particular behavioural phenotype ...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2014.07.026

    authors： Sharma P,Pienaar IS

    更新日期：2014-11-01 00:00:00

  • Towards a neuroscience of empathy: ontogeny, phylogeny, brain mechanisms, context and psychopathology.

    abstract：:Empathy allows individuals to share the affective states of others, predict others' actions, and stimulate prosocial behavior. Whilst the proximate mechanisms of empathy, modulated in part by neuropeptides such as oxytocin, control the ways we interact with our social environment, the ultimate causes seem to have aris...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2013.05.001

    authors： Gonzalez-Liencres C,Shamay-Tsoory SG,Brüne M

    更新日期：2013-09-01 00:00:00

  • Effects of MDMA on complex brain function in laboratory animals.

    abstract：:This review surveys experiments that have examined the effects of acute and chronic MDMA exposure on schedule-controlled operant behaviors thought to engender responses that reflect the expression of complex brain functions. Such functions include time estimation, short-term memory, learning, motivation, and color and...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/0149-7634(95)00064-x

    authors： Frederick DL,Paule MG

    更新日期：1997-01-01 00:00:00

  • Beyond good and evil: A putative continuum-sorting hypothesis for the functional role of proBDNF/BDNF-propeptide/mBDNF in antidepressant treatment.

    abstract：:Depression and posttraumatic stress disorder are assumed to be maladaptive responses to stress and antidepressants are thought to counteract such responses by increasing BDNF (brain-derived neurotrophic factor) levels. BDNF acts through TrkB (tropomyosin-related receptor kinase B) and plays a central role in neuroplas...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2018.04.001

    authors： Diniz CRAF,Casarotto PC,Resstel L,Joca SRL

    更新日期：2018-07-01 00:00:00

  • From single neuron-firing to consciousness--towards the true solution of the binding problem.

    abstract：:The human brain consists of millions of neural nerve cells being interconnected and firing in parallel in order to process information. A fundamental question is how this parallel neuron-firing can result in a unified experience. This is the so-called binding problem--a problem that is one of today's key questions abo...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,收录出版,评审

    doi：10.1016/j.neubiorev.2009.11.014

    authors： Velik R

    更新日期：2010-06-01 00:00:00

  • Adaptation to potential threat: the evolution, neurobiology, and psychopathology of the security motivation system.

    abstract：:The risk of improbable, uncertain, but grave potential dangers poses unique adaptive challenges. We argue that to manage such risks, a special motivational system evolved, which we term the security motivation system. Review of work across a range of species indicates that this system is designed to detect subtle indi...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2010.08.003

    authors： Woody EZ,Szechtman H

    更新日期：2011-03-01 00:00:00

  • Depression biomarkers using non-invasive EEG: A review.

    abstract：:Depression is a serious neurological disorder characterized by strong loss of interest, possibly leading to suicide. According to the World Health Organization, more than 300 million people worldwide suffer from this disorder, being the leading cause of disability. The advancements in electroencephalography (EEG) make...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2019.07.021

    authors： de Aguiar Neto FS,Rosa JLG

    更新日期：2019-10-01 00:00:00

  • Duchenne muscular dystrophy: a cerebellar disorder?

    abstract：:Cyrulnik, S.C., and V.J. Hinton. Duchenne muscular dystrophy: A cerebellar disorder? NEUROSCI. BIOBEHAV. REV. Duchenne muscular dystrophy (DMD) is a genetic disorder that is often associated with cognitive deficits. These cognitive deficits have been linked to the absence of dystrophin, a protein product which is norm...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2007.09.001

    authors： Cyrulnik SE,Hinton VJ

    更新日期：2008-01-01 00:00:00

  • Psychiatric vulnerability: suggestions from animal models and role of neurotrophins.

    abstract：:Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are well-studied neurotrophins involved in the neurogenesis, differentiation, growth and maintenance of selected peripheral and central populations of neuronal cells during development and at adulthood. Neurotrophins, in concert to hypothalamic-pit...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2008.09.004

    authors： Alleva E,Francia N

    更新日期：2009-04-01 00:00:00

  • Tryptophan supplementation modulates social behavior: A review.

    abstract：:Tryptophan (TRP), the precursor of serotonin (5-HT), is one of the most investigated amino-acids. TRP supplementation can increase 5-HT levels in the brain and for this reason numerous studies have investigated whether administration of TRP can positively influence social behavior that relies on serotonergic function....

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2016.02.022

    authors： Steenbergen L,Jongkees BJ,Sellaro R,Colzato LS

    更新日期：2016-05-01 00:00:00

  • Behavioural state affects saccades elicited electrically from neocortex.

    abstract：:Reviewed is how behavioural context influences saccadic eye movements elicited electrically from the neocortex of monkeys. Factors found to affect stimulation-evoked saccades include (1) motor state, i.e. whether stimulation is delivered during free-viewing, or during or after active fixation, or before an animal is a...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2003.10.001

    authors： Tehovnik EJ,Slocum WM

    更新日期：2004-03-01 00:00:00