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Association between asymptomatic carotid stenosis and cognitive function: a systematic review.

Abstract：

BACKGROUND:Asymptomatic carotid stenosis (CS), traditionally considered clinically silent, may be an independent risk factor for a cognitive impairment. METHODS:To determine whether an association exists between asymptomatic CS and cognitive function, we systematically reviewed the literature in the Cochrane Library, MEDLINE, EMBASE and the China National Knowledge Infrastructure databases. RESULTS:A total of 8 cross-sectional studies and 2 community-based cohort studies were included, comprising 763 participants in the CS group and 6308 participants in the non-CS group. All but one study supported the association between asymptomatic CS and cognitive impairment. Pooled analysis identified older age (2 studies) and cerebral hypoperfusion (2 studies) as additional factors in patients with asymptomatic CS that may linked to cognitive decline. CONCLUSIONS:These results suggest that rather than being clinically silent, asymptomatic CS may be associated with cognitive impairment, and this should be further investigated in high-quality studies.

journal_name

Neurosci Biobehav Rev

journal_title

Neuroscience and biobehavioral reviews

authors

Chang XL,Zhou HQ,Lei CY,Wu B,Chen YC,Hao ZL,Dong W,Liu M

doi

10.1016/j.neubiorev.2013.05.011

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

1493-9

issue

8

eissn

0149-7634

issn

1873-7528

pii

S0149-7634(13)00147-4

journal_volume

37

pub_type

杂志文章,评审

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