Abstract:
OBJECTIVES:To systematically evaluate the cost-effectiveness of screening and treatment of familial hypercholesterolaemia (FH). METHODS:An extensive search strategy using MeSH terms was used to search Medline, Embase, EBM review (includes databases such as the Centre for Reviews and Dissemination database), the NHS Economic-Evaluation Database, the HTA database, the Cochrane Library and the Database of Abstracts of Reviews of Effects. Completed studies that evaluated cost-effectiveness of treatment and screening of FH were included. Two reviewers independently assessed the quality of the studies. The studies were assessed using the Consensus on Health-Economic Criteria and a published checklist for evaluating model-based economic evaluations (EE). RESULTS:Nine studies were identified. Three studies that focused on lipid-lowering treatment among patients with known FH suggested this strategy is highly cost-effective. Six studies reported on the cost-effectiveness of FH screening, and subsequent treatment of those identified with the condition. Compared with no screening, the incremental cost-effectiveness ratio of screening ranged from €3177-€29,554 per life year gained. The results of modelled EE were sensitive to the underlying prevalence of FH among the population being screened, the validity of the screening test and the price and efficacy of lipid-lowering therapy. CONCLUSION:Overall, cascade screening for new cases of FH appears to be cost-effective. However, there were uncertainties in the modelling methods, especially with regard to the underlying prevalence of FH, validity of the screening tests, and use of different approaches to assess the outcomes of treatment. Further health EE based on high quality and country-specific data are required.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Ademi Z,Watts GF,Juniper A,Liew Ddoi
10.1016/j.ijcard.2013.01.280subject
Has Abstractpub_date
2013-09-10 00:00:00pages
2391-6issue
6eissn
0167-5273issn
1874-1754pii
S0167-5273(13)00380-Xjournal_volume
167pub_type
杂志文章,评审abstract::Pericardial metastasis is a rare localization of a malignant neoplasm. We report a 28-year-old man with metastatic spread of an epithelial thymoma into the pericardium. This in turn compressed the heart with induction of exertional dyspnea, hepatomegaly, chest pain and increased jugular venous pressure. All these feat...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(88)90038-1
更新日期:1988-01-01 00:00:00
abstract::In this article the authors deal with the intricate relationship between acute brain injuries and stress cardiomyopathies. The complexity of heart–brain relationship raises some questions about the occurrence of Takotsubo cardiomyopathy in young patients with acute brain ischemia and vice versa. ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.05.003
更新日期:2010-11-19 00:00:00
abstract::There continues to be interest in understanding the role of vitamin D in the pathogenesis, epidemiology and prevention of cardiovascular disease (CVD). In fact vitamin D deficiency has been associated to an increased risk of developing CVD given to the relationship between low vitamin D levels and obesity, diabetes me...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2016.12.053
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Left ventricular assist devices (LVAD) are implanted in patients with end-stage heart failure (ESHF) as a mechanical support for the failing myocardium, which is characterized by an activation of the neuro-hormonal system, with release of vasoactive mediators, such as endothelin (ET)-1 and relaxin (RLX)-2. T...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.02.058
更新日期:2020-05-01 00:00:00
abstract::An analysis of the Coronary Artery Surgery Registry (CASS) was performed to determine the occurrence of stroke after coronary artery bypass surgery in patients entered into the Coronary Artery Surgery Study Registry. Of the 10,098 patients having coronary artery bypass surgery at the Coronary Artery Surgery Study part...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/0167-5273(92)90009-r
更新日期:1992-08-01 00:00:00
abstract::To evaluate the effects of chronic smoking on exercise performance we studied 5 smokers and 7 nonsmokers of comparable age and physical characteristics. The resting heart rate in smokers (75 +/- 3 beats/min; mean +/- SD) was significantly (P less than 0.01) higher than in nonsmokers (64 +/- 5). During exercise on a bi...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0167-5273(86)90034-3
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:Unknown is the predictive value of the coronary artery diameter without the administration of vasomotor stimuli. A small reference diameter of the target vessel has been demonstrated to be an adverse prognostic factor in patients undergoing revascularisation. The present study investigated the prognostic val...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.08.037
更新日期:2005-08-18 00:00:00
abstract::A previous trial was completed in 24 patients with coronary heart disease, randomly assigned to a group who undertook a 6-month exercise training programme (5BX/XBX) and a control (no training) group. It was shown that the patients in the training group were able to achieve during exercise a higher heart rate at ST se...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(84)90214-6
更新日期:1984-06-01 00:00:00
abstract:BACKGROUND:For patients in whom statins are not tolerated or effective as monotherapy, proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) represent a new class of lipid lowering therapies that may reduce low-density lipoprotein cholesterol (LDL-C) levels by up to 50% and lower cardiovascular events. Whil...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.04.122
更新日期:2018-09-15 00:00:00
abstract::A 60-year-old male patient with ischemic cardiomyopathy experienced an electrical storm 1 month after implantation of an internal cardioverter-defibrillator. Recurrent life-threatening episodes of ventricular tachycardia persisted despite maximal antiarrhythmic theraphy with amiodarone, metoprolol and mexiletine. Afte...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2003.11.033
更新日期:2005-03-18 00:00:00
abstract::It is important that a cardiologist knows and recognizes the entity of takotsubo cardiomyopathy or apical ballooning, but remains aware that a subsequent similar episode is not necessarily a recurrence of this syndrome. Relapse may be caused by "classical" coronary atherosclerosis, as described in this case report. ...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.04.134
更新日期:2008-07-21 00:00:00
abstract::Clinical guidelines represent statements that seek to synthesize the best evidence to guide a course of action to improve health outcomes and more cost-effective use of resources. However, even when the evidence is not definitive, comprehensive documents are still needed to guide clinical decision-making. In these cir...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2015.06.059
更新日期:2015-11-15 00:00:00
abstract::Autoimmune polyglandular syndromes (APS) consist of the failure of two or more endocrinal glands together requiring hormone replacement. Type II APS, first described by Schmidt in 1926, is the commonest type of APS. In majority of patients, type II APS consists of Addison's disease in combination with autoimmune thyro...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.03.020
更新日期:2011-05-19 00:00:00
abstract:BACKGROUND AND AIMS:It is well known that beta-blockers are useful in patients with chronic heart failure (CHF). These favourable effects have recently been observed even in elderly CHF patients. Objectives of the present study were to evaluate the feasibility, tolerability and safety of carvedilol therapy in a cohort ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.03.028
更新日期:2006-02-15 00:00:00
abstract::During acute myocardial infarction and in the reperfused heart, loss of cardiomyocytes is mostly caused by apoptosis and necrosis. As apoptosis was considered as the only form of regulated cell death for many years, initial studies investigating cardiomyocyte cell death mainly focused on direct inhibition of apoptosis...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2012.03.055
更新日期:2013-05-25 00:00:00
abstract:BACKGROUND:Recent population-based estimates for long-term cardiovascular disease (CVD) mortality after hospitalization for a first acute myocardial infarction (AMI) are not well established. METHODS:Data from the Swedish hospital discharge and death registries were used to record all first-ever hospital admissions in...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2010.10.047
更新日期:2012-03-22 00:00:00
abstract::This investigation was carried out to compare the clinical course of patients with chronic Chagas' heart disease with that of patients with dilated cardiomyopathy. A total of 125 patients (75 chagasic and 50 nonchagasic) prospectively followed up at the Cardiomyopathy clinic of Santa Casa Hospital from January 1990 to...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(97)00083-1
更新日期:1997-07-25 00:00:00
abstract::Migration of retained fractured pacemaker electrodes to the pulmonary artery is a rare but recognised complication. It is imperative that if this occurs the electrode is removed from this position due to the increased risk of associated infection and thrombus formation. Historically open surgery has been required to m...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2009.05.046
更新日期:2011-06-16 00:00:00
abstract::The effect of intracoronary administration of autologous bone marrow cells on autonomic modulation of heart rate has not yet been demonstrated. Therefore, we investigated different parameters of heart rate variability (HRV) in 46 patients without (n=23) or with (n=23) intracoronary stem cell therapy after transmural m...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.07.169
更新日期:2007-07-31 00:00:00
abstract:BACKGROUND:Cardiovascular diseases represent the leading cause of death in Italy and one of the most frequent cause of disability in the elderly. The aim of the study was to investigate the influence of age and sex of patient on the utilisation of cardiac procedure and interventions in Italy. METHODS:Retrospective ana...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2004.03.032
更新日期:2005-05-25 00:00:00
abstract:BACKGROUND:Dilated cardiomyopathy (DCM) incidence during and after anthracycline therapy is highly dependent on anthracycline cumulative dose (CD), but its detailed risk factors remained unexplored. Our aim was to assess heart failure (HF) incidence after epirubicin therapy and construct a HF risk-prediction score. ME...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2019.03.013
更新日期:2019-06-15 00:00:00
abstract::We studied 36 patients with successful transluminal coronary angioplasty (group 1) noninvasively using exercise electrocardiography, exercise T1-201 myocardial scintigraphy and equilibrium radionuclide ventriculography before and 3-5 days after the procedure. Six patients who underwent aortocoronary-bypass surgery (gr...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(83)90169-9
更新日期:1983-06-01 00:00:00
abstract::To examine whether smoking cessation would improve the short-term prognosis for patients with variant angina, 37 smokers with variant angina who were discharged after the complete disappearance of angina by medical treatment with calcium blockers were advised to stop smoking and were followed-up for 1 year. Urinary co...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(94)90019-1
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:The presence of small areas of necrosis has been occasionally reported immediately following apical ballooning syndrome (ABS). However, their persistence at later stages and impact on long-term prognosis are currently unknown. METHODS:Twenty consecutive patients admitted for ABS between 2004 and 2007 were p...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ijcard.2008.08.023
更新日期:2010-02-18 00:00:00
abstract::Central obesity is closely linked to hypertension and type-2 diabetes (DM2) in young/middle-age. In the elderly, systolic hypertension is a reflection of aging/stiff arteries. Diastolic (± systolic) hypertension in young/middle-age is accompanied by increased sympathetic nerve activity, particularly in the presence of...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2014.04.204
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Subcutaneous ICD (S-ICD) is a promising option for Hypertrophic Cardiomyopathy (HCM) patients at risk of Sudden Cardiac Death (SCD). However, its effectiveness in terminating ventricular arrhythmias in HCM is yet unresolved. METHODS:Consecutive HCM patients referred for S-ICD implantation were prospectively...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.12.187
更新日期:2017-03-15 00:00:00
abstract:BACKGROUND:Limited data exist about the clinical presentation and outcomes of patients with inferior vena cava agenesis (IVCA) who develop deep vein thrombosis (DVT). METHODS:We used the RIETE (Registro Informatizado Enfermedad Trombo Embólica) registry to compare clinical characteristics and outcomes of patients with...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2020.01.013
更新日期:2020-04-15 00:00:00
abstract::Fifty three of the 5778 patients included in the MIAMI (Metoprolol in Acute Myocardial Infarction) trial were investigated with long-term ECG recordings in order to evaluate the effect of acute beta-blockade on premature ventricular complexes in and after acute myocardial infarction. Twenty five patients were given pl...
journal_title:International journal of cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0167-5273(87)90335-4
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:Assessment of disease activity in patients with Takayasu's arteritis (TA) is difficult due to absence of definitive tests. Presence of carotid intima-medial thickening has been suggested as a possible marker of inflammation and disease activity. METHODS:We evaluated common carotid artery carotid intima-medi...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2005.05.033
更新日期:2006-04-14 00:00:00
abstract:OBJECTIVE:To assess the importance of an abnormal lipid profile as a risk factor in relation to non-biochemical risk factors, and to define the risk levels for lipid, lipoprotein and apolipoprotein in a Chinese population. PATIENTS AND METHODS:Serum lipids, lipoproteins, apolipoproteins and other cardiovascular risk f...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(93)90038-i
更新日期:1993-06-01 00:00:00