Comparative analysis of adiponectin isoform distribution in pregnant women with gestational diabetes mellitus and after delivery.


OBJECTIVE:To evaluate the distribution of circulating adiponectin isoforms in pregnant women with gestational diabetes mellitus (GDM) and compare isoform distribution changes 12 months after delivery. DESIGN CROSS-SECTIONAL STUDY SETTING:University Hospital. POPULATION:Sixty-four consecutive pregnant women who underwent routine prenatal tests for GDM between 24 and 28 weeks of gestation. The study group included 36 women diagnosed with GDM, 30 of whom underwent re-testing for diabetes 12 months after delivery. The control group included 28 healthy pregnant women. METHODS:Quantitative determination of total adiponectin and its isoforms in serum was performed with the multimeric adiponectin enzyme-linked immunosorbent assay. RESULTS:Total adiponectin concentration in women with GDM was significantly lower than in women without GDM. Among adiponectin isoforms, significantly lower concentrations of multimers and trimers in women with GDM were found in comparison to controls, while the concentration of hexamers did not differ between the groups. After delivery, a significant increase in total adiponectin and in the concentration of multimers and trimers was found in women with history of GDM. Additionally, we found that multimers and hexamers were negatively correlated with body mass index before and during gestation, as well as after delivery, and middle molecular weight isoforms in gestation were negatively correlated with birthweight. CONCLUSIONS:Hypoadiponectinemia during GDM was characterized by a significant, reversible decrease in multimeric levels; thus this isoform seems to function in a cohesive way with total adiponectin. Negative correlations of adiponectin isomers with body mass index indicate that there is a possibility to normalize total adiponectin and prevent GDM.


Matuszek B,Burska A,Leszczyńska-Gorzelak B,Donica H,Nowakowski A




Has Abstract


2013-08-01 00:00:00












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    authors: Andolf EG,Sydsjö GC,Bladh MK,Berg G,Sharma S

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    authors: Bychkov V

    更新日期:1986-01-01 00:00:00

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    journal_title:Acta obstetricia et gynecologica Scandinavica

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    pub_type: 杂志文章


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    authors: Steier JA,Myking OL

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    authors: Korhonen U,Taipale P,Heinonen S

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    authors: al-Zaid NS,Gumaa KA,Bou-Resli MN,Ibrahim ME

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    authors: Martinez LB,Leyva MZ,Romero IC

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    authors: Heinonen K,Saisto T,Gissler M,Kaijomaa M,Sarvilinna N

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    authors: Weber T

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    authors: Kozinszky Z,Orvos H,Zoboki T,Katona M,Wayda K,Pál A,Kovács L

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    authors: Helgesen AL,Gjersvik P,Jebsen P,Kirschner R,Tanbo T

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    journal_title:Acta obstetricia et gynecologica Scandinavica

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    journal_title:Acta obstetricia et gynecologica Scandinavica

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    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:2005-07-01 00:00:00

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    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章


    authors: Forsdahl F,Holst N,Hansen LJ,Bertheussen K

    更新日期:1991-01-01 00:00:00

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    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章


    authors: Soriguer FJ,González-Romero S,Esteva I,García-Arnés JA,Tinahones F,Ruiz de Adana MS,Olveira G,Mancha I,Vazques F

    更新日期:1995-07-01 00:00:00

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    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章


    authors: Hertz JB,Larsen JF,Svenstrup B,Johnsen SG

    更新日期:1979-01-01 00:00:00

  • Stillbirths and rate of neonatal deaths in 76,761 postterm pregnancies in Sweden, 1982-1991: a register study.

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    pub_type: 杂志文章,评审


    authors: Ingemarsson I,Källén K

    更新日期:1997-08-01 00:00:00

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