The relationship between carbohydrate intake and glucose tolerance in pregnant women.

Abstract:

OBJECTIVE:We verified whether a misdiagnosis of gestational diabetes mellitus can result in pregnant women when glucose tolerance has deteriorated after a low-carbohydrate meal, and tried to elucidate the mechanism behind the different outcome of the test. STUDY DESIGN:Twenty-seven pregnant women were given directions for their evening meal the day before each of two 75-g oral glucose tolerance tests (OGTT). The evening meal was either a low-carbohydrate meal (carbohydrate, 6.7%; Low), or a high-carbohydrate meal (carbohydrate, 85.7%; High). RESULTS:The OGTT showed that the glucose tolerance was significantly impaired after Low than after High, with a significant increase of fasting plasma non-esterified fatty acids (NEFA) level. Moreover, the insulinogenic index (I-I) after High significantly decreased than that after Low. CONCLUSIONS:The present data suggests that there is a risk of misdiagnosis of impaired glucose tolerance with only one intake of this extremely low-carbohydrate meal on the evening before testing. The decrease of insulin secretion and the activation of glucose-fatty acid cycle may be considered as the mechanism.

authors

Takizawa M,Kaneko T,Kohno K,Fukada Y,Hoshi K

doi

10.1046/j.1600-0412.2003.00187.x

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

1080-5

issue

12

eissn

0001-6349

issn

1600-0412

pii

187

journal_volume

82

pub_type

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