Abstract:
:Ranolazine is a relatively novel antiischemic/antianginal compound with antiarrhythmic properties. We investigated its ability to shorten the time to conversion of postoperative atrial fibrillation (POAF) when added to amiodarone after coronary artery bypass graft (CABG) surgery. In this prospective, randomized, allocation-concealed, single-blind, single-site clinical trial, we enrolled consecutive eligible patients who developed POAF after elective on-pump CABG surgery. Participants were randomized to receive either ranolazine 375 mg twice daily orally plus intravenous amiodarone (active group) or intravenous amiodarone alone (control group). We enrolled 41 patients; 20 in the active and 21 in the control group. There were no significant differences between the groups in terms of age, procedural duration, extracorporeal circulation time, and aortic cross-clamp time. Mean time of conversion was significantly shorter in the active group (19.9 ± 3.2 vs 37.2 ± 3.9 hours, P < .001), suggesting that compared to amiodarone alone, the ranolazine-amiodarone combination had a superior antiarrhythmic effect against POAF.
journal_name
Angiologyjournal_title
Angiologyauthors
Simopoulos V,Tagarakis GI,Daskalopoulou SS,Daskalopoulos ME,Lenos A,Chryssagis K,Skoularingis I,Molyvdas PA,Tsilimingas NB,Aidonidis Idoi
10.1177/0003319713477911subject
Has Abstractpub_date
2014-04-01 00:00:00pages
294-7issue
4eissn
0003-3197issn
1940-1574pii
0003319713477911journal_volume
65pub_type
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