Abstract:
:The evidence to date on the relation between the risk of venous thromboembolic disease (VTE) and antipsychotic agents derives primarily from observational and case history studies. While an increased risk of VTE has been associated with first-generation low-potency antipsychotic agents, particularly clozapine, there appears to be a growing number of reports on the occurrence of this adverse reaction during the use of second-generation antipsychotics, such as risperidone and olanzapine. The highest risk of pathological blood clotting emerges during the first 3 months after initiation of treatment with the product. Potential etiopathogenetic factors leading to VTE during treatment with antipsychotic agents include sedation, obesity, elevation of antiphospholipid antibodies, increased platelet activation and aggregation, hyperhomocysteinemia, and hyperprolactinemia. Diagnoses of schizophrenia and/or bipolar affective disorder, as well as hospitalization or stress with sympathetic activation and elevation of catecholamine levels, have been reported as known prothrombogenic factors. The present article contains the new version of the guideline for the prevention of VTE in psychiatric patients with limited mobility. Further prospective studies are necessary to elucidate the biological mechanisms of the relations between antipsychotic agents and VTE.
journal_name
Psychiatry Clin Neuroscijournal_title
Psychiatry and clinical neurosciencesauthors
Masopust J,Malý R,Vališ Mdoi
10.1111/pcn.12001subject
Has Abstractpub_date
2012-12-01 00:00:00pages
541-52issue
7eissn
1323-1316issn
1440-1819journal_volume
66pub_type
杂志文章,评审abstract::Among 448 patients with obstructive sleep apnea-hypopnea syndrome (OSAHS), 40 patients (8.9%) had been involved in one or more automobile accidents during the preceding 5 years. The main cause of these accidents was falling asleep while driving. Excessive sleepiness during driving was associated with an Epworth sleepi...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2002.01004.x
更新日期:2002-06-01 00:00:00
abstract::A modified version of the Waldrop scale (WS) was used to assess the prevalence of minor physical anomalies in schizophrenic patients (n = 71) and healthy controls (n = 65). The mean total WS score was 3.32 (SD 1.98) for the schizophrenic patients, significantly higher than that for the controls (2.19, SD 1.18). Minor ...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
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更新日期:2003-02-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
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doi:10.1111/j.1440-1819.1998.tb01009.x
更新日期:1998-04-01 00:00:00
abstract:AIMS:This paper examines the relationship between observational behavior and the observers' result assumptions, using a contained diagram that includes significant non-verbal information, such as gestures. The ability of care workers to assess a patient's mental status on the basis of non-verbal information would be co...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2010.02077.x
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2001.00844.x
更新日期:2001-06-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
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doi:10.1111/j.1440-1819.2003.01210.x
更新日期:2004-04-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章,meta分析
doi:10.1111/pcn.12976
更新日期:2020-04-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/pcn.12091
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journal_title:Psychiatry and clinical neurosciences
pub_type: 临床试验,杂志文章
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更新日期:2005-04-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.1995.tb01862.x
更新日期:1995-03-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2010.02102.x
更新日期:2010-08-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2006.01524.x
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journal_title:Psychiatry and clinical neurosciences
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doi:10.1046/j.1440-1819.2001.00909.x
更新日期:2001-12-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2009.01996.x
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abstract::The validity of two kinds of brief intelligence tests for patients with Alzheimer's disease (AD) was investigated. In study 1, five short forms of the Japanese Wechsler Adult Intelligence Scale-Revised (JWAIS-R) were administered to 102 AD patients. The results showed that the intra-class correlation coefficients (ICC...
journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
pub_type: 临床试验,杂志文章
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更新日期:2005-06-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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doi:10.1111/j.1440-1819.1998.tb00989.x
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