Paramutation: a trans-homolog interaction affecting heritable gene regulation.

Abstract:

:Paramutation describes both the process and results of trans-sensing between chromosomes that causes specific heritable changes in gene regulation. RNA molecules are implicated in mediating similar events in maize, mouse, and Drosophila. Changes in both small RNA profiles and cytosine methylation patterns in Arabidopsis hybrids represent a potential molecular equivalent to the interactions responsible for paramutations. Despite a seemingly unifying feature of RNA-directed changes, both recent and historical works show that paramutations in maize require plant-specific proteins and lack expected hallmarks of a trans-effect mediated solely by RNAs. Recent examples of nearby transposons affecting RNA polymerase II functions lead to an opinion that paramutations represent an emergent property of the transcriptional dynamics ongoing in plant genomes between repetitious features and nearby genes.

journal_name

Curr Opin Plant Biol

authors

Hollick JB

doi

10.1016/j.pbi.2012.09.003

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

536-43

issue

5

eissn

1369-5266

issn

1879-0356

pii

S1369-5266(12)00115-X

journal_volume

15

pub_type

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