Abstract:
:Despite recent advances in the management of thyroid cancer, the survival rate of this tumor may still be improved. Therefore, the identification of biological and molecular features of indolent and aggressive disease would be critical to define clinically useful predictors of high-risk lesions. microRNAs (miRNAs) are small RNA molecules with regulatory function and marked tissue specificity that modulate multiple targets belonging to several pathways. They are frequently deregulated in cancer and constitute a new class of blood-based biomarkers useful for cancer detection and prognosis definition, including thyroid cancer. In this review, the role of miRNAs in thyroid cancer development is described. The most common miRNAs detected in thyroid cancer along with their clinical significance are also discussed. Further studies aimed to detect plasma-based miRNA biomarkers in thyroid cancer patients may provide further insight into the management of thyroid cancer.
journal_name
Int J Mol Medjournal_title
International journal of molecular medicineauthors
Leonardi GC,Candido S,Carbone M,Colaianni V,Garozzo SF,Cinà D,Libra Mdoi
10.3892/ijmm.2012.1089subject
Has Abstractpub_date
2012-11-01 00:00:00pages
991-9issue
5eissn
1107-3756issn
1791-244Xjournal_volume
30pub_type
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