Abstract:
:Developments in microarray and high-throughput sequencing (HTS) technologies have resulted in a rapid expansion of research into epigenomic changes that occur in normal development and in the progression of disease, such as cancer. Not surprisingly, copy number variation (CNV) has a direct effect on HTS read densities and can therefore bias differential detection results. We have developed a flexible approach called ABCD-DNA (affinity-based copy-number-aware differential quantitative DNA sequencing analyses) that integrates CNV and other systematic factors directly into the differential enrichment engine.
journal_name
Genome Resjournal_title
Genome researchauthors
Robinson MD,Strbenac D,Stirzaker C,Statham AL,Song J,Speed TP,Clark SJdoi
10.1101/gr.139055.112subject
Has Abstractpub_date
2012-12-01 00:00:00pages
2489-96issue
12eissn
1088-9051issn
1549-5469pii
gr.139055.112journal_volume
22pub_type
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