Perspective on neuromuscular factors in poststroke fatigue.

Abstract:

PURPOSE:To summarize the potential origins of fatigue poststroke from a neuromuscular perspective, including stroke-induced alterations at the cortical, spinal and muscle levels. METHOD:Perspective based on narrative literature review. RESULTS:Fatigue is a highly prevalent, but poorly understood symptom poststroke. Neuromuscular fatigue has central and peripheral origins. Individuals with stroke experienced greater central fatigue and less peripheral fatigue during voluntary contractions of the paretic leg in comparison to healthy participants. Neuromuscular adaptations to stroke create an increased susceptibility to central fatigue, which may be a contributing factor to the increased perception of tiredness during performance of activities of daily living. Future studies should investigate whether intervention-induced cortical plasticity, gains in muscle strength and endurance will attenuate self-reported fatigability. CONCLUSIONS:Fatigue is a common and debilitating consequence of stroke. Neuromuscular fatigue of central origin may contribute to self-reported fatigue. Continued focused and properly designed research studies should provide substantial insight into the therapeutic interventions that will improve the management of fatigue poststroke.

journal_name

Disabil Rehabil

authors

Knorr S,Rice CL,Garland SJ

doi

10.3109/09638288.2012.683233

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

2291-9

issue

26

eissn

0963-8288

issn

1464-5165

journal_volume

34

pub_type

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