Comet assay to assess the genotoxicity of Persian walnut (Juglans regia L.) husks with statistical evaluation.

Abstract:

:The aim of this study was to confirm the utility of the Comet assay as a genotoxicity screening test for evaluating the impact of walnut husk aqueous extract. Phytotoxicity assays using diluted and undiluted walnut husk aqueous extracts were performed on young roots of Raphanus sativus (radish), and the Comet assay was used to evaluate DNA integrity in isolated radish radicle nuclei. The results reveal a dose-dependent accumulation of DNA damage in radish radicles treated with walnut husks water extract and that the Kolmogorov-Smirnov test combined with Johnson SB distribution was the best approach for describing Comet assay data.

authors

Petriccione M,Ciniglia C

doi

10.1007/s00128-012-0637-4

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

166-71

issue

1

eissn

0007-4861

issn

1432-0800

journal_volume

89

pub_type

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