Abstract：
BACKGROUND:The kidney performs a multitude of essential functions to maintain homeostasis. In clinical medicine, glomerular filtration rate (GFR) provides the best index of overall kidney function, and proteinuria adds additional information on renal and nonrenal prognosis. Several novel biomarkers of kidney injury and function are under investigation. CONTENT:Plasma creatinine concentration is the most widely used measure for estimation of GFR. Plasma cystatin C and β-trace protein may eventually prove to be superior to creatinine. GFR may be measured directly by use of exogenous filtration markers, although their role is primarily limited to the research setting. Real-time, noninvasive measurement of GFR by using fluorescently labeled markers may be available in the future. Novel biomarkers of tubular injury such as neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, liver-type fatty acid binding protein, N-acetyl-β-(D)-glucosaminidase, and interleukin-18 may enable the early detection of acute kidney injury before or in the absence of a change in GFR. SUMMARY:A variety of methods are available to assist clinicians in the assessment of kidney function and injury. Ongoing investigation will help determine the utility of several new markers and clarify their role in the care of patients with and at risk for kidney disease.
journal_name
Clin Chemjournal_title
Clinical chemistryauthors
Ferguson MA,Waikar SSdoi
10.1373/clinchem.2011.167494subject
Has Abstractpub_date
2012-04-01 00:00:00pages
680-9issue
4eissn
0009-9147issn
1530-8561pii
clinchem.2011.167494journal_volume
58pub_type
杂志文章,评审abstract：:A radioimmunoassay for 1,25-dihydroxycholecalciferol which did not cross react with 1,25-dihydroxyergocalciferol is described. IgG fractions were prepared from the serum of rabbits that had been immunized with 1,25-dihydroxycholecalciferol-3-hemisuccinate coupled to bovine albumin. Radioligand binding by the IgG fract...
journal_title：Clinical chemistry
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更新日期：1981-03-01 00:00:00
abstract：BACKGROUND:Newborn screening for deficiency in the lysosomal enzymes that cause Fabry, Gaucher, Krabbe, Niemann-Pick A/B, and Pompe diseases is warranted because treatment for these syndromes is now available or anticipated in the near feature. We describe a multiplex screening method for all five lysosomal enzymes tha...
journal_title：Clinical chemistry
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doi：10.1373/clinchem.2004.035907
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doi：10.1373/clinchem.2004.040311
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journal_title：Clinical chemistry
pub_type： 杂志文章,评审
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journal_title：Clinical chemistry
pub_type： 杂志文章
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journal_title：Clinical chemistry
pub_type： 杂志文章,评审
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journal_title：Clinical chemistry
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doi：
更新日期：1986-01-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1976-08-01 00:00:00
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journal_title：Clinical chemistry
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journal_title：Clinical chemistry
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更新日期：1992-12-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章,评审
doi：
更新日期：1994-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1373/clinchem.2009.125856
更新日期：2010-01-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章,多中心研究
doi：
更新日期：2002-09-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：2000-04-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
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doi：10.1373/clinchem.2018.291104
更新日期：2019-03-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1977-03-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
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journal_title：Clinical chemistry
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更新日期：1997-08-01 00:00:00
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journal_title：Clinical chemistry
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更新日期：1978-12-01 00:00:00
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journal_title：Clinical chemistry
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journal_title：Clinical chemistry
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doi：
更新日期：2001-06-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1993-06-01 00:00:00
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journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
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doi：
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