Abstract:
OBJECTIVE:To present the design, methods, and rationale of the Child/Adolescent Anxiety Multimodal Study (CAMS), a recently completed federally-funded, multi-site, randomized placebo-controlled trial that examined the relative efficacy of cognitive-behavior therapy (CBT), sertraline (SRT), and their combination (COMB) against pill placebo (PBO) for the treatment of separation anxiety disorder (SAD), generalized anxiety disorder (GAD) and social phobia (SoP) in children and adolescents. METHODS:Following a brief review of the acute outcomes of the CAMS trial, as well as the psychosocial and pharmacologic treatment literature for pediatric anxiety disorders, the design and methods of the CAMS trial are described. RESULTS:CAMS was a six-year, six-site, randomized controlled trial. Four hundred eighty-eight (N = 488) children and adolescents (ages 7-17 years) with DSM-IV-TR diagnoses of SAD, GAD, or SoP were randomly assigned to one of four treatment conditions: CBT, SRT, COMB, or PBO. Assessments of anxiety symptoms, safety, and functional outcomes, as well as putative mediators and moderators of treatment response were completed in a multi-measure, multi-informant fashion. Manual-based therapies, trained clinicians and independent evaluators were used to ensure treatment and assessment fidelity. A multi-layered administrative structure with representation from all sites facilitated cross-site coordination of the entire trial, study protocols and quality assurance. CONCLUSIONS:CAMS offers a model for clinical trials methods applicable to psychosocial and psychopharmacological comparative treatment trials by using state-of-the-art methods and rigorous cross-site quality controls. CAMS also provided a large-scale examination of the relative and combined efficacy and safety of the best evidenced-based psychosocial (CBT) and pharmacologic (SSRI) treatments to date for the most commonly occurring pediatric anxiety disorders. Primary and secondary results of CAMS will hold important implications for informing practice-relevant decisions regarding the initial treatment of youth with anxiety disorders. TRIAL REGISTRATION:ClinicalTrials.gov NCT00052078.
journal_name
Child Adolesc Psychiatry Ment Healthjournal_title
Child and adolescent psychiatry and mental healthauthors
Compton SN,Walkup JT,Albano AM,Piacentini JC,Birmaher B,Sherrill JT,Ginsburg GS,Rynn MA,McCracken JT,Waslick BD,Iyengar S,Kendall PC,March JSdoi
10.1186/1753-2000-4-1subject
Has Abstractpub_date
2010-01-05 00:00:00pages
1issn
1753-2000pii
1753-2000-4-1journal_volume
4pub_type
杂志文章abstract:BACKGROUND:Autism is a biological disorder with clearly defined phenomenology. Studies from the Middle East on this topic have been particularly rare. Little is known about the influence of culture on clinical features, presentations and management of autism. The current study was done to compare characteristics of aut...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/1753-2000-5-34
更新日期:2011-11-03 00:00:00
abstract:UNLABELLED:This paper presents the rationale, design, and methods of the Pediatric Obsessive-Compulsive Disorder Treatment Study II (POTS II), which investigates two different cognitive-behavior therapy (CBT) augmentation approaches in children and adolescents who have experienced a partial response to pharmacotherapy ...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/1753-2000-3-4
更新日期:2009-01-30 00:00:00
abstract::Parents can transmit their anxiety to their child, and just as children can pick up on parental anxiety, they can also respond to a parent's ability to stay calm in stressful situations. Therefore, when treating children, it is important to address parental anxiety and to improve their understanding of their child's a...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/1753-2000-1-7
更新日期:2007-08-02 00:00:00
abstract::The Hastings Center, a bioethics research institute, is holding a series of 5 workshops to examine the controversies surrounding the use of medication to treat emotional and behavioral disturbances in children. These workshops bring together clinicians, researchers, scholars, and advocates with diverse perspectives an...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/1753-2000-3-1
更新日期:2009-01-19 00:00:00
abstract:BACKGROUND:Young offenders are known to be a population with high prevalence of mental health disorders. In most cases, these disorders are neither identified nor treated properly, with the majority of them being chronic and difficult to treat. In many countries, the prevalence rates of psychopathology in male young of...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/s13034-016-0131-6
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:To evaluate health-related quality of life (HRQL) and medication satisfaction after switching from a stable dose of oral extended-release methylphenidate (ER-MPH) to methylphenidate transdermal system (MTS) via a dose-transition schedule in children with attention-deficit/hyperactivity disorder (ADHD). METH...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/1753-2000-3-39
更新日期:2009-12-10 00:00:00
abstract:BACKGROUND:Loneliness is associated with peer victimization, and the two adverse experiences are both related to ill health in childhood and adolescence. There is, however, a lack of knowledge on the importance of loneliness among victimized children. Therefore, possible modifying effects of loneliness on victimized sc...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/1753-2000-6-20
更新日期:2012-05-29 00:00:00
abstract:BACKGROUND:There are indications that teachers have limited knowledge about attention deficit hyperactivity disorder (ADHD), despite its high prevalence in childhood and its long-term effects on students such as academic underachievement, reduced self-esteem, and social and behavioural difficulties. This study is there...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/s13034-017-0153-8
更新日期:2017-03-20 00:00:00
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journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章,评审
doi:10.1186/s13034-016-0104-9
更新日期:2016-06-14 00:00:00
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journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/1753-2000-7-4
更新日期:2013-02-13 00:00:00
abstract:BACKGROUND:The transition from high school to post-secondary education and work is difficult for adolescents on the autism spectrum. Transition planning can be an effective way of supporting adolescents on the autism spectrum to prepare for leaving school and to succeed in obtaining employment; however, there is a need...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/s13034-016-0137-0
更新日期:2016-12-28 00:00:00
abstract::For the first time, we publish a special section of four related articles in the online, open-access journal Child and Adolescent Psychiatry and Mental Health. ...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 社论
doi:10.1186/1753-2000-2-35
更新日期:2008-12-08 00:00:00
abstract:Background:The coronavirus disease 2019 (COVID-19) is profoundly affecting life around the globe. Isolation, contact restrictions and economic shutdown impose a complete change to the psychosocial environment in affected countries. These measures have the potential to threaten the mental health of children and adolesce...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章,评审
doi:10.1186/s13034-020-00329-3
更新日期:2020-05-12 00:00:00
abstract:BACKGROUND:Early intervention and preventive interventions are attracting increasing attention in the child and adolescent mental health field because recent research findings offer new insights into risk mechanisms and because of the growing expectation that they may hold clues to reducing suffering and health cost bu...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/1753-2000-3-24
更新日期:2009-09-04 00:00:00
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journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/s13034-015-0036-9
更新日期:2015-02-12 00:00:00
abstract:BACKGROUND:Adolescents rarely seek psychiatric help; they even hesitate to disclose their feelings to their parents. However; the adolescents especially the females experience depressive symptoms more frequently than general population. Do they experience classic depressive symptoms? Are there symptoms specific to this...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/1753-2000-4-26
更新日期:2010-10-10 00:00:00
abstract:BACKGROUND:Both early alcohol debut, behavioural and health problems are reported to enhance adolescence substance use. This prospective study investigate the influence of behavioural and health problems on adolescents' alcohol and drug use. METHOD:Prospective population based cohort study of 2 399 adolescents attendi...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/1753-2000-5-17
更新日期:2011-05-20 00:00:00
abstract::The situation of crisis produced by the Coronavirus (COVID-19) pandemic poses major challenges to societies all over the world. While efforts to contain the virus are vital to protect global health, these same efforts are exposing children and adolescents to an increased risk of family violence. Various criminological...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章,评审
doi:10.1186/s13034-020-00347-1
更新日期:2020-10-20 00:00:00
abstract:BACKGROUND:The aim of this study is to investigate the psychometric properties and the perceived usefulness of the BARO (Dutch: BAsisRaadsOnderzoek; Protection Board Preliminary Examination of Juvenile Suspects). The BARO is a first-line screening instrument for the identification of psychiatric disorders, adverse envi...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/1753-2000-5-24
更新日期:2011-06-29 00:00:00
abstract:BACKGROUND:Parents are the ones who decide whether or not to participate in parent focused prevention trials. Their decisions may be affected by internal factors (e.g., personality, attitudes, sociodemographic characteristics) or external barriers. Some of these barriers are study-related and others are intervention-re...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/1753-2000-4-15
更新日期:2010-05-28 00:00:00
abstract:BACKGROUND:Although child welfare youth and juvenile offenders in residential care have different judicial placement reasons, there seems to be overlap in their demographic and psychosocial backgrounds. This could raise the question whether these adolescents should be placed in strictly separated institutions based on ...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/s13034-020-00355-1
更新日期:2021-01-21 00:00:00
abstract:Background:Obesity has become a global problem in childhood and adolescence. The objective of the present study was to investigate the impact of family communication and function, and body image satisfaction, on psychological well-being by considering: the mediating role of self-esteem and depression. Methods:In this ...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/s13034-020-00345-3
更新日期:2020-10-12 00:00:00
abstract:OBJECTIVES:We examined whether co-rumination with online friends buffered the link between social anxiety and depressive symptoms over time in a community sample. METHODS:In a sample of 526 participants (358 girls; M age = 14.05) followed at three time points, we conducted...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/s13034-017-0179-y
更新日期:2017-08-22 00:00:00
abstract:Background:One in seven members of China's population are migrants. There are an estimated 41 million children left behind in rural areas who are living without one or both of their parents. The impact of two- and single-parent migration on child mental health and risk behaviors is unclear. The aim of this study was to...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/s13034-019-0298-8
更新日期:2019-10-22 00:00:00
abstract:Background:Nepal is a developing low-income country in Southeast Asia. There is a huge burden of child and adolescent mental health (CAMH) in Nepal which has a population of around 29 million and 40-50% of the population comprises of children and adolescents. Child and Adolescent Psychiatry (CAP) has not been formally ...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/s13034-020-00319-5
更新日期:2020-04-06 00:00:00
abstract:Background:Studies throughout Europe have shown that asylum-seeking children and adolescents (ASC) are at risk of developing mental disorders. The most common mental-health problems in ASC include posttraumatic stress symptoms (PTSS), internalizing symptoms such as depression and anxiety, and externalizing behaviour. B...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/s13034-019-0268-1
更新日期:2019-01-30 00:00:00
abstract:Background:The population in juvenile justice institutions is heterogeneous, as juveniles display a large variety of individual, psychological and social problems. This variety of risk factors and personal characteristics complicates treatment planning. Insight into subgroups and specific profiles of problems in seriou...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/s13034-017-0201-4
更新日期:2017-12-22 00:00:00
abstract:BACKGROUND:Mental health problems (MHPs) in preschoolers are precursors of mental disorders which have shown to be associated with suffering, functional impairment, exposure to stigma and discrimination, as well as enhanced risk of premature death. A better understanding of factors associated with MHPs in preschoolers ...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/s13034-017-0149-4
更新日期:2017-03-08 00:00:00
abstract:BACKGROUND:Parents' perspectives on their children's treatment process and outcomes are valuable to treatment development and improvement. Participants' engagement in Routine Outcome Monitoring (ROM) has, however, been difficult and may particularly be so in specialized settings, such as semi-residential psychiatry. In...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/s13034-015-0049-4
更新日期:2015-06-11 00:00:00
abstract:BACKGROUND:Current clinical knowledge suggests that children can have different types of depressive symptoms (irritability and aggression), but presents no theoretical basis for these differences. Using a developmental approach, the present study sought to test the relationship between developmental level (mental age) ...
journal_title:Child and adolescent psychiatry and mental health
pub_type: 杂志文章
doi:10.1186/1753-2000-1-9
更新日期:2007-08-22 00:00:00