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The Pediatric Obsessive-Compulsive Disorder Treatment Study II: rationale, design and methods.

Abstract：

UNLABELLED:This paper presents the rationale, design, and methods of the Pediatric Obsessive-Compulsive Disorder Treatment Study II (POTS II), which investigates two different cognitive-behavior therapy (CBT) augmentation approaches in children and adolescents who have experienced a partial response to pharmacotherapy with a serotonin reuptake inhibitor for OCD. The two CBT approaches test a "single doctor" versus "dual doctor" model of service delivery. A specific goal was to develop and test an easily disseminated protocol whereby child psychiatrists would provide instructions in core CBT procedures recommended for pediatric OCD (e.g., hierarchy development, in vivo exposure homework) during routine medical management of OCD (I-CBT). The conventional "dual doctor" CBT protocol consists of 14 visits over 12 weeks involving: (1) psychoeducation, (2), cognitive training, (3) mapping OCD, and (4) exposure with response prevention (EX/RP). I-CBT is a 7-session version of CBT that does not include imaginal exposure or therapist-assisted EX/RP. In this study, we compared 12 weeks of medication management (MM) provided by a study psychiatrist (MM only) with two types of CBT augmentation: (1) the dual doctor model (MM+CBT); and (2) the single doctor model (MM+I-CBT). The design balanced elements of an efficacy study (e.g., random assignment, independent ratings) with effectiveness research aims (e.g., differences in specific SRI medications, dosages, treatment providers). The study is wrapping up recruitment of 140 youth ages 7-17 with a primary diagnosis of OCD. Independent evaluators (IEs) rated participants at weeks 0,4,8, and 12 during acute treatment and at 3,6, and 12 month follow-up visits. TRIAL REGISTRATION:NCT00074815.

journal_name

Child Adolesc Psychiatry Ment Health

journal_title

Child and adolescent psychiatry and mental health

authors

Freeman JB,Choate-Summers ML,Garcia AM,Moore PS,Sapyta JJ,Khanna MS,March JS,Foa EB,Franklin ME

doi

10.1186/1753-2000-3-4

subject

Has Abstract

pub_date

2009-01-30 00:00:00

pages

4

issue

1

issn

1753-2000

pii

1753-2000-3-4

journal_volume

3

pub_type

杂志文章

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