Protective effects of Ginkgo biloba extract on ligature-induced periodontitis in rats.

Abstract:

OBJECTIVE:The aim of this study was to test the hypothesis that the systemic administration of extract of Ginkgo biloba (EGb) would prevent excessive tissue destruction in ligature-induced periodontitis in a rat model. MATERIALS AND METHODS:Thirty-two male Wistar albino rats were used in the current study. The rats were randomly divided into four groups of eight rats each: (1) non-ligated treatment (NL) group, (2) ligature-only (LO) group, (3) ligature plus GB28 (28 mg/kg, daily for 11 days) group and (4) ligature plus GB56 (56 mg/kg, daily for 11 days) group. RESULTS:Measurement of alveolar bone loss in the mandibular molar tooth revealed significantly lower bone loss values in the LO group compared to groups NL, GB28 and GB56 (p < 0.05). CONCLUSION:The present results are the first data which suggests that host response in periodontitis can be modified by EGb administration. EGb minimized progression of periodontal disease.

journal_name

Acta Odontol Scand

authors

Sezer U,Kara Mİ,Ercıyas K,Ozdemir H,Üstün K,Ozer H,Göze F

doi

10.3109/00016357.2011.650195

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

38-44

issue

1

eissn

0001-6357

issn

1502-3850

journal_volume

71

pub_type

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