Potential therapeutic targeting of platelet-mediated cellular interactions in atherosclerosis and inflammation.

abstract：:Drug repositioning is a strategy to identify new uses for approved or investigational drugs that are used off-label outside the scope of the original medical indication. In this review we report the most relevant studies about drug repositioning in hematology, reporting the signalling pathways and molecular targets of...

journal_title：Current medicinal chemistry

authors： Allegra A,Imbesi C,Bitto A,Ettari R

更新日期：2020-08-16 00:00:00

abstract：:Ornithine transcarbamylase (OTC; EC 2.1.3.3) is a one-carbon-unit transferring enzyme that synthesizes citrulline using ornithine and carbamoylphosphate as substrates. It is involved in the metabolic transformation of arginine and proline, and it participates in the urea cycle in vertebrates and in the formation of pu...

journal_title：Current medicinal chemistry

authors： Díaz-Muñoz M,Hernández-Muñoz R

更新日期：2010-01-01 00:00:00

abstract：:Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hybrid compound with improved affinity and efficacy, when compared to the parent drugs. Additionally, this strategy can result in compounds pres...

journal_title：Current medicinal chemistry

authors： Viegas-Junior C,Danuello A,da Silva Bolzani V,Barreiro EJ,Fraga CA

更新日期：2007-01-01 00:00:00

abstract：:The discovery and development of novel drugs has been influenced over the last several decades by new techniques in medicinal chemistry. Combinatorial and parallel synthesis chemistry techniques have opened up immense opportunities in drug discovery and development efforts. These techniques, which include solid phase ...

journal_title：Current medicinal chemistry

authors： Musonda CC,Chibale K

更新日期：2004-10-01 00:00:00

abstract：:Dendritic cells (DCs) play a central role in the establishment of tolerance/immunity, because they activate naïve T cells (TCs). Therefore, the pharmacological modulation of DCs has become a major field of interest in immunology. A large body of literature has arisen from the studies of DC biology during immunosuppres...

journal_title：Current medicinal chemistry

authors： Schlichting CL,Schareck WD,Nickel T,Weis M

更新日期：2005-01-01 00:00:00

abstract：:The hyaluronidases (HAases) are a group of less extensively studied glycosidases distributed throughout the animal kingdom and are popularly known as 'spreading factors'. In recent years, HAases received much attention due to their ability to abruptly alter the hyaluronic acid (HA) homeostasis. HAases preferentially d...

journal_title：Current medicinal chemistry

authors： Girish KS,Kemparaju K,Nagaraju S,Vishwanath BS

更新日期：2009-01-01 00:00:00

abstract：:Agents modulating apoptosis are of extraordinary promise for the treatment of several states of disease including cancer, AIDS, neurodegenerative and ischemic diseases. In this review a brief summary of cellular pathways relevant to programmed cell death first is given and potential therapeutic targets therein are emp...

journal_title：Current medicinal chemistry

authors： Deigner HP,Kinscherf R

更新日期：1999-05-01 00:00:00

abstract：:Vitamin D has been known for a long time as a major factor involved in the calcium- phosphate balance and homeostasis, along with parathyroid hormone (PTH). While vitamin D effects on calcium and phosphate are fully known, recent studies attempted to link vitamin D status and cardiovascular diseases. The involvement o...

journal_title：Current medicinal chemistry

authors： Santoro D,Pellicanò V,Cernaro V,Lacava V,Lacquaniti A,Atteritano M,Buemi M

更新日期：2016-01-01 00:00:00

abstract：:Receptor-binding peptides have attracted an enormous interest in targeting molecules for the development of tumour specific radiopharmaceutical compounds. The overexpression of many receptors on human tumour makes such peptide-ligands attractive agents for diagnostic imaging and therapy of cancers. The use of solid-ph...

journal_title：Current medicinal chemistry

authors： Bolzati C,Refosco F,Marchiani A,Ruzza P

更新日期：2010-01-01 00:00:00

abstract：:The story of antimalarials as antinflammatory drugs dates back several centuries. Chinin, the extract of the Cinchona bark, has been exploited since the 18th century for its antimalarial and antifebrile properties. Later, during the Second World War, the broad use of antimalarials allowed arguing their antirheumatic e...

journal_title：Current medicinal chemistry

authors： Piscianz E,Cuzzoni E,Sharma R,Tesser A,Sapra P,Tommasini A

更新日期：2018-01-01 00:00:00

abstract：:Iron is a key element for every single living process. On a fundamental level, targeting iron is a valuable approach for the treatment of disorders caused by iron overload. Utilizing iron chelators as therapeutic agents has received expanding consideration in chelation therapy. Approved low molecular weight (MW) iron ...

journal_title：Current medicinal chemistry

authors： Bulbake U,Singh A,Domb AJ,Khan W

更新日期：2019-01-01 00:00:00

abstract：:With the recent market approval of Pitolisant (Wakix®), the interest in clinical application for novel multifunctional histamine H3 receptor antagonists has clearly increased. Several combinations of different H3R pharmacophores with pharmacophoric elements of other G-protein coupled receptors, transporters or enzymes...

journal_title：Current medicinal chemistry

authors： Szczepańska K,Kuder KJ,Kieć-Kononowicz K

更新日期：2020-08-05 00:00:00

abstract：:Tumor necrosis factor (TNF) is a cytokine with well known anticancer properties and is being utilized as anticancer agent for the treatment of patients with locally advanced solid tumors. However, TNF role in cancer biology is debated. In fact, in spite of the wealth of evidence supporting its antitumor activity, the ...

journal_title：Current medicinal chemistry

authors： Bertazza L,Mocellin S

更新日期：2010-01-01 00:00:00

abstract：:Within the pharmaceutical industry, the ultimate source of continuing profitability is the unremitting process of drug discovery. To be profitable, drugs must be marketable: legally novel, safe and relatively free of side effects, efficacious, and ideally inexpensive to produce. While drug discovery was once typified ...

journal_title：Current medicinal chemistry

authors： Hattotuwagama CK,Davies MN,Flower DR

更新日期：2006-01-01 00:00:00

abstract：:Paclitaxel has been proven to be effective against different types of cancer. A delivery system loaded with paclitaxel at tumor site should provide a high local concentration of the drug detrimental to malignant cells, which prevents the re-growth and metastasis of tumor. In this review, paclitaxel formulations for sy...

journal_title：Current medicinal chemistry

authors： Pawar R,Shikanov A,Vaisman B,Domb AJ

更新日期：2004-02-01 00:00:00

abstract：:Mitogen-activated protein kinase p38 is a serine/threonine kinase originally isolated from lipopolysaccharide (LPS) stimulated monocytes. There are four isoforms p38alpha p38beta, p38gamma, and p38delta. The most thoroughly studied isoform is p38alpha, whose activation has been observed in many hematopoietic and non-h...

journal_title：Current medicinal chemistry

authors： Lee MR,Dominguez C

更新日期：2005-01-01 00:00:00

abstract：:Excitatory neurotransmission mediated by NMDA (N-methyl-D-aspartic acid) receptors plays a key role in both healthy and diseased processes in the brain. Therefore, bioactive compounds that can interact selectively with these receptors have been the aim of extensive research in the search of effective therapeutic agent...

journal_title：Current medicinal chemistry

authors： Bonaccorso C,Micale N,Ettari R,Grasso S,Zappalà M

更新日期：2011-01-01 00:00:00

abstract：:Fourier-transform infrared (FT-IR) based mapping and imaging is a fast emerging technology which is being increasingly applied to investigate tissues in the high-throughput mode. The high resolution close to the cellular level, the possibility to determine the bio-distribution of molecules of interest (proteins, pepti...

journal_title：Current medicinal chemistry

authors： Petter CH,Heigl N,Rainer M,Bakry R,Pallua J,Bonn GK,Huck CW

更新日期：2009-01-01 00:00:00

abstract：:Glucocorticoids (GC) play a fundamental role in controlling physiologic homeostasis and, when present in excess, can have a detrimental impact on glucose control, blood pressure and lipid levels. The oxidoreductase 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) mainly catalyzes the intracellular regeneration...

journal_title：Current medicinal chemistry

authors： Ge R,Huang Y,Liang G,Li X

更新日期：2010-01-01 00:00:00

abstract：:This update covers the literature for 2002 and 2003 dealing with the main topic of the previous review entitled Heterocyclic nucleosides. Chemical synthesis and biological properties and published in Curr. Med. Chem.-AIA, 2002, 1, 389. As in the first review, the papers in this survey are grouped by the type of the he...

journal_title：Current medicinal chemistry

authors： Merino P

更新日期：2006-01-01 00:00:00

abstract：:Systemic Lupus Erythematosus (SLE) is a chronic and relapsing heterogenous autoimmune disease that primarily affects women of reproductive age. Genetic and environmental risk factors are involved in the pathogenesis of SLE, and susceptibility genes have recently been identified. However, as gene therapy is far from cl...

journal_title：Current medicinal chemistry

authors： Pan Q,Guo Y,Guo L,Liao S,Zhao C,Wang S,Liu HF

更新日期：2020-01-01 00:00:00

abstract：: ...

journal_title：Current medicinal chemistry

authors： Biava PM,Nicolini A

更新日期：2019-01-01 00:00:00

abstract：:Many of the currently available treatments for obsessive-compulsive and related disorders (OCRDs) such as pharmacotherapy augmentation strategies, partial hospitalization programs, deep brain stimulation, and neurosurgery are efficacious for individuals suffering from more severe forms of these conditions. Unfortunate...

journal_title：Current medicinal chemistry

authors： Fontenelle LF,Zeni-Graiff M,Quintas JN,Yücel M

更新日期：2018-01-01 00:00:00

abstract：:Specific noncovalent interactions that are indicative of attractive, directional intermolecular forces have always been of key interest to medicinal chemists in their search for the "glue" that holds drugs and their targets together. With the rapid increase in the number of solved biomolecular structures as well as th...

journal_title：Current medicinal chemistry

authors： Zhou P,Huang J,Tian F

更新日期：2012-01-01 00:00:00

abstract：:Pentacyclic triterpenoids including the oleanane, ursane and lupane groups are widely distributed in many medicinal plants, such as Glycyrrhiza species, Gymnema species, Centella asiatica, Camellia sinensis, Crataegus species and Olea europaea, which are commonly used in traditional medicine for the treatment of diabe...

journal_title：Current medicinal chemistry

authors： Alqahtani A,Hamid K,Kam A,Wong KH,Abdelhak Z,Razmovski-Naumovski V,Chan K,Li KM,Groundwater PW,Li GQ

更新日期：2013-01-01 00:00:00

abstract：:gamma-Amino butyric acid is an extremely important inhibitory neurotransmitter in the mammalian central nervous system and is essential for the overall balance between neuronal excitation and inhibition. It is well documented that GABA deficiency is associated with several important neurological disorders such as Hunt...

journal_title：Current medicinal chemistry

authors： Gajcy K,Lochyński S,Librowski T

更新日期：2010-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a highly complex and rapidly progressive neurodegenerative disorder characterized by the systemic collapse of cognitive function and formation of dense amyloid plaques and neurofibrillary tangles. AD pathology is derived from the cholinergic, amyloid and tau hypotheses, respectively. Curren...

journal_title：Current medicinal chemistry

authors： Mohamed T,Rao PP

更新日期：2011-01-01 00:00:00

abstract：:Lipopolysaccharide (LPS), which constitutes the lipid portion of the outer leaflet of Gram-negative bacteria, is essential for growth. It is also responsible for the variety of biological effects associated with Gram-negative sepsis. Recent advances have elucidated the exact chemical structure of this highly complex m...

journal_title：Current medicinal chemistry

authors： Cipolla L,Polissi A,Airoldi C,Gabrielli L,Merlo S,Nicotra F

更新日期：2011-01-01 00:00:00

abstract：:Small conductance Ca(2+)-activated K(+) (SK(Ca)) channels comprise an important subclass of K(+) channels. Selective blockade of SK(Ca) channels may find application in the therapy of myotonic muscular dystrophy, gastrointestinal dysmotilities, memory disorders, narcolepsy, and alcohol abuse. In the cyclophanes descri...

journal_title：Current medicinal chemistry

authors： Conejo-García A,Campos JM

更新日期：2008-01-01 00:00:00

abstract：:A growing body of evidence has shown that oxidative stress may be involved in the development of vascular complications associated with diabetes. However, the molecular mechanism for increased reactive oxygen species (ROS) production in diabetes remains uncertain. Among various possible mechanisms, attention have incr...

journal_title：Current medicinal chemistry

authors： Inoguchi T,Tsubouchi H,Etoh T,Kakimoto M,Sonta T,Utsumi H,Sumimoto H,Yu HY,Sonoda N,Inuo M,Sato N,Sekiguchi N,Kobayashi K,Nawata H

更新日期：2003-09-01 00:00:00