Molecular hybridization: a useful tool in the design of new drug prototypes.

abstract：:Ca(2+) is a highly versatile intracellular second messenger in the central nervous system, and regulates many complicated cellular processes, including excitation, plasticity and apoptosis. Influx of Ca(2+) from the extracellular fluid is required for sustained elevation of the cytosolic Ca(2+) concentration and full ...

journal_title：Current medicinal chemistry

authors： Yagami T,Kohma H,Yamamoto Y

更新日期：2012-01-01 00:00:00

abstract：:Recent advances in endoscopic techniques such as capsule endoscopy have revealed that aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) often cause mucosal lesions not only in the upper gastrointestinal tract, but also in the small intestine in humans. Gastric and duodenal lesions caused by NSAIDs can be ...

journal_title：Current medicinal chemistry

authors： Satoh H,Takeuchi K

更新日期：2012-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an age-related neurodegenerative disorder that is believed to have complex genetic and environmental influences in the pathogenesis, but etiologies are unidentified for most patients. Until the major causes are better defined, drug development is directed at downstream pathophysi...

journal_title：Current medicinal chemistry

authors： Blasco H,Mavel S,Corcia P,Gordon PH

更新日期：2014-01-01 00:00:00

abstract：:For more than 20 years there has been increasing interest in the development of novel therapies to raise levels of high-density lipoprotein cholesterol (HDL-C). However, well publicized failures of recent clinical trials of agents that raise HDL-C levels have stimulated considerable controversy with regard to the pote...

journal_title：Current medicinal chemistry

authors： Duong M,Nicholls SJ

更新日期：2014-01-01 00:00:00

abstract：:The inhibition of protein degradation through the ubiquitin-proteasome pathway is a recently developed approach to cancer treatment which extends the range of cellular targets for chemotherapy. This therapeutic strategy is very interesting since the proteasomes carry out the regulated degradation of unnecessary or dam...

journal_title：Current medicinal chemistry

authors： Gilardini A,Marmiroli P,Cavaletti G

更新日期：2008-01-01 00:00:00

abstract：:Bioactivation of xenobiotics can, in certain circumstances, result in the formation of reactive electrophilic species. These reactive metabolites may covalently modify proteins and macromolecules and it has been suggested that protein modification is a key initial step in provoking idiosyncratic adverse drug reactions...

journal_title：Current medicinal chemistry

authors： Edwards PJ,Sturino C

更新日期：2011-01-01 00:00:00

abstract：:Since the beginning of the 20th century, important medicinal progress has led medical doctors to think that the end of devastating epidemics has arrived. In 1930, the discovery of sulfamides and penicillin opened a wide area of applications able to fight against bacterial infections. However, almost all antibiotics we...

journal_title：Current medicinal chemistry

authors： Salzet M

更新日期：2005-01-01 00:00:00

abstract：:Chemoprevention is based on the use of non-toxic, pharmacologically active agents to prevent tumor progression. In this regard, natural dietary agents have been described by the most recent literature as promising tools for controlling onset and progression of malignancies. Extensive research has been so far performed...

journal_title：Current medicinal chemistry

authors： Raimondi L,De Luca A,Giavaresi G,Barone A,Tagliaferri P,Tassone P,Amodio N

更新日期：2020-01-01 00:00:00

abstract：:Gum resin extracts of Boswellia species have been traditionally applied in folk medicine for centuries to treat various chronic inflammatory diseases, and experimental data from animal models and studies with human subjects confirmed the potential of B. spec extracts for the treatment of not only inflammation but also...

journal_title：Current medicinal chemistry

authors： Poeckel D,Werz O

更新日期：2006-01-01 00:00:00

abstract：:Although the renin-angiotensin system (RAS) is already an old acquaintance, there are often exciting discoveries that improve our knowledge of it and open new therapeutic possibilities. Moreover, well-established drugs, such as angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), or be...

journal_title：Current medicinal chemistry

authors： Ramírez-Sánchez M,Prieto I,Wangensteen R,Banegas I,Segarra AB,Villarejo AB,Vives F,Cobo J,de Gasparo M

更新日期：2013-01-01 00:00:00

abstract：:Infections with Mycobacterium tuberculosis, the causative agent of tuberculosis, are difficult to treat using currently available chemotherapeutics. Clinicians agree on the urgent need for novel drugs to treat tuberculosis. In this mini review, we summarize data that prompts the consideration of DNA repair-associated ...

journal_title：Current medicinal chemistry

authors： Minias A,Brzostek A,Dziadek J

更新日期：2019-01-01 00:00:00

abstract：:The lung is a unique organ in terms of its direct exposure to high levels of oxygen and reactive compounds. Several parenchymal lung diseases (e.g. emphysema associated with smoking and a number of fibrotic lung disorders) have been proposed to be due to the exposure of the lung to exogenous irritants leading to local...

journal_title：Current medicinal chemistry

authors： Kinnula VL,Vuorinen K,Ilumets H,Rytilä P,Myllärniemi M

更新日期：2007-01-01 00:00:00

abstract：:Antimitotics binding at the colchicine site of tubulin are important antitumour and vascular disrupting agents. Pyridines and azines are privileged scaffolds in medicinal chemistry and in recent years many colchicine site ligands (CSL) have incorporated them into their structures with the aim of improving their pharma...

journal_title：Current medicinal chemistry

authors： Álvarez R,Aramburu L,Puebla P,Caballero E,González M,Vicente A,Medarde M,Peláez R

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Post-exercise cardiac troponin T (cTnT) release has been widely reported in adult athletes but limited data is available for adolescents. The aim of this study was to determine the incidence and magnitude of cTnT appearance in a large group of adolescent runners, and to determine any association between cTnT...

journal_title：Current medicinal chemistry

authors： Nie J,George KP,Tong TK,Gaze D,Tian Y,Lin H,Shi Q

更新日期：2011-01-01 00:00:00

abstract：:Kit is a growth factor receptor of the type III tyrosine kinase family, whose gain-of-function mutations have been identified as driving causes of different kinds of tumours. It thus represents a viable drug target, and the development of Kit inhibitors has been shown to be a promising therapeutic concept. This review...

journal_title：Current medicinal chemistry

authors： Sartini S,Dario B,Morelli M,Da Settimo F,La Motta C

更新日期：2011-01-01 00:00:00

abstract：:Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has been a global challenge. The complicated forms of the Coronavirus Disease 2019 (COVID-19) can evolve to multiple-organ failure, including several coagulopathies related to a sudden worsening of respiratory status. This article aimed to review s...

journal_title：Current medicinal chemistry

authors： Pena ALB,Oliveira RA,Severo RG,Simões E Silva AC

更新日期：2020-10-05 00:00:00

abstract：:Galectins form a family of carbohydrate-binding proteins defined by their affinity for beta-galactosides containing glycoconjugates. The carbohydrate recognition domain (CRD) is responsible for the specificity of galectins for saccharides. This binding may result in modulated cell proliferation, cell death and cell mi...

journal_title：Current medicinal chemistry

authors： Ingrassia L,Camby I,Lefranc F,Mathieu V,Nshimyumukiza P,Darro F,Kiss R

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:In view of many current mosquito-borne diseases there is a need for the design of novel repellents. OBJECTIVE:The objective of this article is to review the results of the researches carried out by the authors in the computer-assisted design of novel mosquito repellents. METHODS:Two methods in the computat...

journal_title：Current medicinal chemistry

authors： Basak SC,Bhattacharjee AK

更新日期：2020-01-01 00:00:00

abstract：:Molecules in biological systems often can perform more than one function. In particular, many molecules have the ability to chemically scavenge free radicals and thus act in the test tube as antioxidant, but their main biological function is by acting as hormones, ligands for transcription factors, modulators of enzym...

journal_title：Current medicinal chemistry

authors： Zingg JM,Azzi A

更新日期：2004-05-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) plays an important role in the onset and prognosis of myocardial infarction. Targets of angiotensin converting enzyme (ACE) inhibitors might include not only ACE but also MMP-9, and ACE seems to be closely associated with complications of hypertension such as cardiovascular remodelin...

journal_title：Current medicinal chemistry

authors： Yamamoto D,Takai S

更新日期：2009-01-01 00:00:00

abstract：:Protein Kinase Inhibitors (PKIs) and Histone Deacetylase Inhibitors (HDACIs) are two important classes of anticancer agents and have provided a variety of small molecule drugs for the treatment of various types of human cancers. However, malignant tumors are of a multifactorial nature that can hardly be "cured" by tar...

journal_title：Current medicinal chemistry

authors： Ling Y,Liu J,Qian J,Meng C,Guo J,Gao W,Xiong B,Ling C,Zhang Y

更新日期：2020-01-01 00:00:00

abstract：:Many non-cardiovascular drugs of common clinical use cause, as an unwanted accessory property, the prolongation of the cardiac repolarisation process, due to the block of the HERG (Human Ether-a-go-go Related Gene) potassium channel, responsible for the repolarising I(Kr) current. This delayed cardiac repolarisation p...

journal_title：Current medicinal chemistry

authors： Testai L,Bianucci AM,Massarelli I,Breschi MC,Martinotti E,Calderone V

更新日期：2004-10-01 00:00:00

abstract：:Transglutaminases (TGases) are enzymes which catalyze the cross linking of a glutaminyl residue of a protein/peptide substrate to a lysyl residue of a protein/peptide co-substrate with the formation of an N-gamma-(epsilon-L-glutamyl)-L-lysine [GGEL] cross link (isopeptidic bond) and the concomitant release of ammonia....

journal_title：Current medicinal chemistry

authors： Martin A,Romito G,Pepe I,De Vivo G,Merola MR,Limatola A,Gentile V

更新日期：2006-01-01 00:00:00

abstract：:Mitochondria are cytoplasmic double-membraned organelles that are involved in a myriad of key cellular regulatory processes. The loss of mitochondrial function is related to the pathogenesis of several human diseases. Over the last decades, an increasing number of studies have shown that dietary polyphenols can regula...

journal_title：Current medicinal chemistry

authors： Teixeira J,Chavarria D,Borges F,Wojtczak L,Wieckowski MR,Karkucinska-Wieckowska A,Oliveira PJ

更新日期：2019-01-01 00:00:00

abstract：:Dendritic cells (DCs) are the most powerful antigen-presenting cells which link the innate and adaptive immune responses. Depending on the context DCs initiate the immune responses or contribute to immune tolerance. Any disturbance in their phenotypes and functions may initiate inflammatory or autoimmune diseases. Hen...

journal_title：Current medicinal chemistry

authors： Rahimi K,Hassanzadeh K,Khanbabaei H,Haftcheshmeh SM,Ahmadi A,Izadpanah E,Mohammadi A,Sahebkar A

更新日期：2020-05-14 00:00:00

abstract：BACKGROUND:Numerous studies have reported sex and gender differences in the prevalence and treatment of cardiovascular diseases. However, sex differences in the therapy of hypertension have not been completely examined. OBJECTIVE:To estimate the gender-specific dissimilarity in outcomes among patients following antihy...

journal_title：Current medicinal chemistry

authors： Giorgini P,Sahebkar A,Stamerra CA,Raparelli V,Petrarca M,Grassi D,Ferri C,Di Giosia P

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Numerous studies have demonstrated that halogenated agents elicit myocardial conditioning effects when adminis-tered perioperatively in cardiac surgery. Recent evidence has been published of the benefits of maintaining exposure to halogenated agents during the early postoperative period. The enzymatic mechan...

journal_title：Current medicinal chemistry

authors： Guerrero Orriach JL,Escalona Belmonte JJ,Ramirez Aliaga M,Ramirez Fernandez A,Rodriguez Capitan MJ,Quesada Muñoz G,Raigón Ponferrada A,Alcaide Torres J,Santiago-Fernandez C,Matute Gonzalez E,Rubio Navarro M,Bautista R,Gómez Maldo

更新日期：2020-10-01 00:00:00

abstract：:Limitations associated with the production cost, metabolic instability, side-effects, resistance and poor pharmacokinetics of organic protease inhibitors (PIs), which form an essential component of the front line HAART treatment for HIV, have fuelled efforts into finding novel, transition metal-based alternatives. Som...

journal_title：Current medicinal chemistry

authors： Kellett A,Prisecaru A,Slator C,Molphy Z,McCann M

更新日期：2013-01-01 00:00:00

abstract：:A growing body of evidence has shown that oxidative stress may be involved in the development of vascular complications associated with diabetes. However, the molecular mechanism for increased reactive oxygen species (ROS) production in diabetes remains uncertain. Among various possible mechanisms, attention have incr...

journal_title：Current medicinal chemistry

authors： Inoguchi T,Tsubouchi H,Etoh T,Kakimoto M,Sonta T,Utsumi H,Sumimoto H,Yu HY,Sonoda N,Inuo M,Sato N,Sekiguchi N,Kobayashi K,Nawata H

更新日期：2003-09-01 00:00:00

abstract：:The non-steroidal anti-inflammatory drugs (NSAIDs) are diverse group of compounds used for the treatment of inflammation, since the introduction of acetylsalicylic acid in 1899. Traditional (first generation) NSAIDs exert antiinflammatory, analgesic, and antipyretic effects through the blockade of prostaglandin synthe...

journal_title：Current medicinal chemistry

authors： Chakraborti AK,Garg SK,Kumar R,Motiwala HF,Jadhavar PS

更新日期：2010-01-01 00:00:00