Abstract:
:Despite the availability of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) infection, there has not been a dramatic decrease in the frequency of progressive multifocal leukoencephalopathy (PML) in the HIV-infected population. Usually a multifocal progressive disease of nonenhancing lesions in white matter, PML can have distinct characteristics in HIV-infected patients, including unifocal static lesions of faint contrast enhancement on imaging and involvement of gray matter. A syndrome of cerebellar degeneration has been described in association with HIV infection in patients positive for JC virus, the papovavirus responsible for PML. The standard of care for HIV-associated PML is HAART to achieve immunologic recovery and optimal HIV virologic control. The prognosis of PML has improved greatly since the advent of HAART.
journal_name
Cleve Clin J Medjournal_title
Cleveland Clinic journal of medicineauthors
Simpson DMdoi
10.3949/ccjm.78.s2.06subject
Has Abstractpub_date
2011-11-01 00:00:00pages
S24-7eissn
0891-1150issn
1939-2869pii
78/Suppl_2/S24journal_volume
78 Suppl 2pub_type
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