Structural integrity of the prefrontal cortex modulates electrocortical sensitivity to reward.

Abstract:

:The P300 is a known ERP component assessing stimulus value, including the value of a monetary reward. In parallel, the incentive value of reinforcers relies on the PFC, a major cortical projection region of the mesocortical reward pathway. Here we show a significant positive correlation between P300 response to money (vs. no money) with PFC gray matter volume in the OFC, ACC, and dorsolateral and ventrolateral PFC in healthy control participants. In contrast, individuals with cocaine use disorders showed compromises in both P300 sensitivity to money and PFC gray matter volume in the ventrolateral PFC and OFC and their interdependence. These results document for the first time the importance of gray matter structural integrity of subregions of PFC to the reward-modulated P300 response.

journal_name

J Cogn Neurosci

authors

Parvaz MA,Konova AB,Tomasi D,Volkow ND,Goldstein RZ

doi

10.1162/jocn_a_00166

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

1560-70

issue

7

eissn

0898-929X

issn

1530-8898

journal_volume

24

pub_type

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