Abstract:
:The P300 is a known ERP component assessing stimulus value, including the value of a monetary reward. In parallel, the incentive value of reinforcers relies on the PFC, a major cortical projection region of the mesocortical reward pathway. Here we show a significant positive correlation between P300 response to money (vs. no money) with PFC gray matter volume in the OFC, ACC, and dorsolateral and ventrolateral PFC in healthy control participants. In contrast, individuals with cocaine use disorders showed compromises in both P300 sensitivity to money and PFC gray matter volume in the ventrolateral PFC and OFC and their interdependence. These results document for the first time the importance of gray matter structural integrity of subregions of PFC to the reward-modulated P300 response.
journal_name
J Cogn Neuroscijournal_title
Journal of cognitive neuroscienceauthors
Parvaz MA,Konova AB,Tomasi D,Volkow ND,Goldstein RZdoi
10.1162/jocn_a_00166subject
Has Abstractpub_date
2012-07-01 00:00:00pages
1560-70issue
7eissn
0898-929Xissn
1530-8898journal_volume
24pub_type
杂志文章,随机对照试验abstract::People can discriminate real words from nonwords even when the latter are orthographically and phonologically word-like, presumably because words activate specific lexical and/or semantic information. We investigated the neural correlates of this identification process using event-related functional magnetic resonance...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/089892903321593108
更新日期:2003-04-01 00:00:00
abstract::Contextual modulation reported in early- to intermediate-level visual areas could be an essential component to signal border ownership (BO) that specifies the direction of figure along a contour. The surrounding regions that evoke significant suppression or facilitation are highly localized and asymmetric with respect...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.2006.18.4.562
更新日期:2006-04-01 00:00:00
abstract::Interactions between stimuli's acoustic features and experience-based internal models of the environment enable listeners to compensate for the disruptions in auditory streams that are regularly encountered in noisy environments. However, whether auditory gaps are filled in predictively or restored a posteriori remain...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn_a_00835
更新日期:2015-10-01 00:00:00
abstract::The Müller-Lyer illusion occurs both in vision and in touch, and transfers cross-modally from vision to haptics [Mancini, F., Bricolo, E., & Vallar, G. Multisensory integration in the Müller-Lyer illusion: From vision to haptics. Quarterly Journal of Experimental Psychology, 63, 818-830, 2010]. Recent evidence suggest...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.2010.21561
更新日期:2011-08-01 00:00:00
abstract::Recent fMRI studies have found that distinct neural systems may mediate perceptual category learning under implicit and explicit learning conditions. In these previous studies, however, different stimulus-encoding processes may have been associated with implicit versus explicit learning. The present design was aimed a...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.2010.21538
更新日期:2011-07-01 00:00:00
abstract::The visual system has been commonly subdivided into two segregated visual processing streams: The dorsal pathway processes mainly spatial information, and the ventral pathway specializes in object perception. Recent findings, however, indicate that different forms of interaction (cross-talk) exist between the dorsal a...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn_a_00497
更新日期:2014-02-01 00:00:00
abstract::After few seconds, a figure steadily presented in peripheral vision becomes perceptually filled-in by its background, as if it "disappeared". We report that directing attention to the color, shape, or location of a figure increased the probability of perceiving filling-in compared to unattended figures, without modify...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/089892906775990561
更新日期:2006-03-01 00:00:00
abstract::We investigated localization performance of simple targets in patient TN, who suffered bilateral damage of his primary visual cortex and shows complete cortical blindness. Using a two-alternative forced-choice paradigm, TN was asked to guess the position of left-right targets with goal-directed and discrete manual res...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn_a_00404
更新日期:2013-10-01 00:00:00
abstract::Cortical neurotransmitter availability is known to exert domain-specific effects on cognitive performance. Hence, normal variation in genes with a role in neurotransmission may also have specific effects on cognition. We tested this hypothesis by examining associations between polymorphisms in genes affecting choliner...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/089892905774597281
更新日期:2005-10-01 00:00:00
abstract::We distinguish between strong and weak cognitive neuropsychology, with the former attempting to provide direct insights into the nature of information processing and the latter having the more modest goal of providing constraints on such theories. We argue that strong cognitive neuropsychology, although possible, is u...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.1992.4.1.96
更新日期:1992-01-01 00:00:00
abstract::A fundamental question for social cognitive neuroscience is how and where in the brain the identities and actions of others are represented. Here we present a replication and extension of a study by Kable and Chatterjee [Kable, J. W., & Chatterjee, A. Specificity of action representations in the lateral occipito-tempo...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.2010.21552
更新日期:2011-07-01 00:00:00
abstract::Recent studies have shown that (1) the global precedence effects in processing the hierarchically organized stimulus can be attenuated by eliminating the low spatial frequencies contained in the stimulus and (2) the human magnocellular pathway is responsible for processing low spatial frequencies and the pathway can b...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/089892999563201
更新日期:1999-01-01 00:00:00
abstract::Recent interest has been drawn to the separate components of recognition memory, as studied by event-related potentials (ERPs). In ERPs, recollection is usually accompanied by a late, parietal positive deflection. An earlier, frontal component has been suggested to be a counterpart, accompanying recognition by familia...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.2009.21045
更新日期:2009-03-01 00:00:00
abstract::In order to test the language-specificity of a known neural correlate of syntactic processing [the P600 event-related brain potential (ERP) component], this study directly compared ERPs elicited by syntactic incongruities in language and music. Using principles of phrase structure for language and principles of harmon...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/089892998563121
更新日期:1998-11-01 00:00:00
abstract::Visual evoked responses were monitored while participants searched for a target (e.g., bird) in a four-object display that could include a semantically related distractor (e.g., fish). The occurrence of both the target and the semantically related distractor modulated the N2pc response to the search display: The N2pc ...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.2009.21348
更新日期:2010-10-01 00:00:00
abstract::What are the implications of anatomical localization of component mental operations for cognitive models? In this paper we use the anatomical localizations of visual and auditory word processing that were previously reported from PET studies (Petersen, Fox, Posner, Mintun & Raichle, 1988. We hypothesize that two opera...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.1989.1.1.50
更新日期:1989-01-01 00:00:00
abstract::Using a speeded lexical decision task, event-related potentials (ERPs), and minimum norm current source estimates, we investigated early spatiotemporal aspects of cortical activation elicited by words and pseudo-words that varied in their orthographic typicality, that is, in the frequency of their component letter pai...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.2006.18.5.818
更新日期:2006-05-01 00:00:00
abstract::We investigated the sources of dual-task costs arising in multisensory working memory (WM) tasks, where stimuli from different modalities have to be simultaneously maintained. Performance decrements relative to unimodal single-task baselines have been attributed to a modality-unspecific central WM store, but such cost...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn_a_01348
更新日期:2019-02-01 00:00:00
abstract::We study the interplay between motor programs and their timing in the brain by using precise pulses of transcranial magnetic stimulation (TMS) applied to the primary motor cortex. The movement of the finger performing a tapping task is periodically perturbed in synchronization with a metronome. TMS perturbation can pr...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.2007.19.5.721
更新日期:2007-05-01 00:00:00
abstract::Attention selects objects or groups as the most fundamental unit, and this may be achieved through a process in which attention automatically spreads throughout their entire region. Previously, we found that a lateralized potential relative to an attended hemifield at occipito-temporal electrode sites reflects attenti...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.2008.21158
更新日期:2010-01-01 00:00:00
abstract::People are able to adapt their behavior to changing environmental contingencies by rapidly inhibiting or modifying their actions. Response inhibition is often studied in the stop-signal paradigm that requires the suppression of an already prepared motor response. Less is known about situations calling for a change of ...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.2010.21573
更新日期:2011-09-01 00:00:00
abstract::This study was designed to explore whether the human visual system has different degrees of tolerance to character position changes for letter strings, digit strings, and symbol strings. An explicit perceptual matching task was used (same-different judgment), and participants' electrophysiological activity was recorde...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1162/jocn_a_00180
更新日期:2012-07-01 00:00:00
abstract::Emotional attention, the boosting of the processing of emotionally relevant stimuli, has, up to now, mainly been investigated within a sensory modality, for instance, by using emotional pictures to modulate visual attention. In real-life environments, however, humans typically encounter simultaneous input to several d...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.2009.21110
更新日期:2009-09-01 00:00:00
abstract::Two fundamental research questions have driven attention research in the past: One concerns whether selection of relevant information among competing, irrelevant, information takes place at an early or at a late processing stage; the other concerns whether the capacity of attention is limited by a central, domain-gene...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1162/jocn_a_00275
更新日期:2012-11-01 00:00:00
abstract::At birth, human infants and newborns of other primate species demonstrate the capacity to attend and to respond to facial stimuli provided by a caregiver. Newborn infants are also capable of exhibiting a range of facial expressions. Identification of the neural underpinnings of these capacities represents a formidable...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn_a_00198
更新日期:2012-05-01 00:00:00
abstract::Learning a new word requires discrimination between a novel sequence of sounds and similar known words. We investigated whether semantic information facilitates the acquisition of new phonological representations in adults and whether this learning enhancement is modulated by overnight consolidation. Participants lear...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn_a_00730
更新日期:2015-04-01 00:00:00
abstract::The specific contributions of distal dendrites to the computational properties of cortical neurons are little understood and are completely ignored in most network simulations of higher brain functions. Compartmental models, based on realistic estimates of morphology and physiology, provide a means for exploring these...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.1989.1.3.273
更新日期:1989-07-01 00:00:00
abstract::The concept of "monitoring" refers to our ability to control our actions on-line. Monitoring involved in speech production is often described in psycholinguistic models as an inherent part of the language system. We probed the specificity of speech monitoring in two psycholinguistic experiments where electroencephalog...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1162/jocn.2010.21467
更新日期:2011-06-01 00:00:00
abstract::Traditional auditory oddball paradigms imply the brain's ability to encode regularities, but are not optimal for investigating the process of regularity establishment. In the present study, a dynamic experimental protocol was developed that simulates a more realistic auditory environment with changing regularities. Th...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.2007.19.10.1664
更新日期:2007-10-01 00:00:00
abstract::Abstract A neural model is described of how the brain may autonomously learn a body-centered representation of a three-dimensional (3-D) target position by combining information about retinal target position, eye position, and head position in real time. Such a body-centered spatial representation enables accurate mov...
journal_title:Journal of cognitive neuroscience
pub_type: 杂志文章
doi:10.1162/jocn.1994.6.4.341
更新日期:1994-10-01 00:00:00