Abstract：
PURPOSE:To determine whether the addition of a bioadhesive drug-delivery system to topical azithromycin induces intraocular inflammation and damage when introduced intraocularly by different approaches and in varying doses. SETTING:John A. Moran Eye Center, Salt Lake City, Utah, USA. DESIGN:Experimental study. METHODS:Commercial topical azithromycin 1.0% was duplicated, including the benzalkonium chloride, but without inclusion of the Durasite bioadhesive drug-delivery system. Injections of 50 μL, 25 μL, and 10 μL of the antibiotic solutions were administered in a masked fashion to 2 rabbits; 1 eye (study eye) in each rabbit was randomized to receive azithromycin with the delivery system and the fellow eye (control eye) to receive azithromycin without the delivery system. Two rabbits had topical drops of each solution placed after a 2.8 mm incision was created. Masked slitlamp examinations, pachymetry, and intraocular pressure (IOP) were determined 1 day and 2 days postoperatively. The animals were humanely killed, and the endothelial density and histopathology were examined. RESULTS:The IOP (P<.001), pachymetry (P<.001), and signs of inflammation (P=.38 to .003) were consistently higher in the study eye, especially at the 50 μL dose, than in the control eye. This was confirmed by histopathology. CONCLUSION:If the drug-delivery system gains access to the anterior chamber, it may cause substantial corneal edema and inflammation, even at low doses and after topical administration.
journal_name
J Cataract Refract Surgjournal_title
Journal of cataract and refractive surgeryauthors
Goecks T,Werner L,Mamalis N,Fuller SR,Jensen M,Kavoussi SC,Hill M,Olson RJdoi
10.1016/j.jcrs.2011.06.038subject
Has Abstractpub_date
2012-01-01 00:00:00pages
137-45issue
1eissn
0886-3350issn
1873-4502pii
S0886-3350(11)01496-9journal_volume
38pub_type
杂志文章abstract：:Four patients with diabetes mellitus had cataract extraction with implantation of a hydrophilic acrylic intraocular lens (IOL) (ACRL-C160, Ophthalmed). The IOLs showed progressive and generalized opacification 10 to 20 months after implantation, decreasing visual acuity. All 4 IOLs were removed. By light microscopic e...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(02)01245-2
更新日期：2002-07-01 00:00:00
abstract：PURPOSE:To assess the safety and effectiveness of an immunotoxin, MDX-RA, designed to inhibit posterior capsule opacification (PCO). SETTING:Eleven private practices in the United States. METHODS:This study comprised 63 eyes of 63 patients having extracapsular cataract extraction by phacoemulsification; these patient...
journal_title：Journal of cataract and refractive surgery
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0886-3350(98)80352-0
更新日期：1998-12-01 00:00:00
abstract：:Deep anterior lamellar keratoplasty is a widely adopted technique to treat pathologies of the cornea without endothelial cell involvement. This technique has several advantages including longer graft survival without endothelial rejection and lower doses of steroid administration. A transillumination technique was use...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000369
更新日期：2020-08-03 00:00:00
abstract：PURPOSE:To report the incidence, management, and prevention of patient reports of glare and streaks around a point source of light or a dark shadow in the temporal field of vision after acrylic intraocular lens (IOL) implantation. SETTING:A private practice. METHODS:Cases in which patients complained vigorously of dy...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(00)00611-8
更新日期：2000-09-01 00:00:00
abstract：PURPOSE:To establish whether small incision cataract surgery with phacoemulsification decreases the risk of acute suprachoroidal hemorrhage (ASCH) compared with traditional nucleus expression by extracapsular cataract extraction (ECCE). SETTING:St. Erik Eye Hospital, Stockholm, Sweden. METHODS:A retrospective study w...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(98)80133-8
更新日期：1998-06-01 00:00:00
abstract：PURPOSE:To correlate the observed fluorescence spectrum with the depth of ablation during 193 nm argon-fluoride excimer laser ablation of chemically damaged corneas. SETTING:Laser facility, Cedars-Sinai Medical Center, Los Angeles, California, USA. METHODS:Three cadaver New Zealand white rabbit corneas were exposed t...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(02)01361-5
更新日期：2002-10-01 00:00:00
abstract：:We describe a case of corneal chromoblastomycosis with Cladophialophora carrionii in a 69-year-old woman 4 weeks after clear corneal cataract surgery. The patient presented with right eye pain and decreased visual acuity of 20/100. Examination showed a deep posterior stromal keratitis accompanied by a dense fibrinous ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2011.03.007
更新日期：2011-05-01 00:00:00
abstract：PURPOSE:To study the intensity of trypan blue and fluorescein staining over time in anterior lens capsules and various intraocular lens (IOL) materials. SETTING:Fritz Eye Associates, Geislingen, Germany. METHODS:Excised anterior lens capsules and IOLs were exposed to trypan blue 0.1% and fluorescein 2% solution to as...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(02)01238-5
更新日期：2002-06-01 00:00:00
abstract：:A 25-year-old woman with myopia who had an AC pIOL implantation in the left eye and posterior chamber pIOL implantation in the right eye developed bilateral granulomatous panuveitis 2 months after the second surgery. Physical examination showed bilateral Koeppe and Busacca nodules. Fluorescein angiography showed diffu...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2012.02.026
更新日期：2012-06-01 00:00:00
abstract：UNLABELLED:We report a 66-year-old patient who presented with increasing hyperopia, astigmatism, and presbyopia in both eyes 8 years after bilateral laser in situ keratomileusis (LASIK) and LASIK enhancement in the left eye aiming for spectacle independence. Bilateral multifocal toric Lentis Mplus intraocular lenses (I...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2012.08.042
更新日期：2012-11-01 00:00:00
abstract：PURPOSE:To assess the accuracy of intraocular lens (IOL) power calculation formulas in Chinese eyes with axial lengths (ALs) longer than 26.0 mm. SETTING:Department of Cataract Surgery, Shanxi Eye Hospital, China. DESIGN:Prospective case series. METHODS:This study evaluated (1) two new formulas (Barrett Universal II...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2019.01.018
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:To understand, demonstrate, and further research the mechanisms of accommodation and presbyopia. SETTING:Private practice, Little Silver, New Jersey, USA. DESIGN:Experimental study. METHODS:The CAMA 2.0 computer-animated model of accommodation and presbyopia was produced in collaboration with an experienced ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2014.07.028
更新日期：2015-02-01 00:00:00
abstract：:We present a case of traumatic lens subluxation that was evident only when the patient was in the supine position. This case illustrates that a crystalline lens with traumatic zonular rupture can change its position depending on the posture of the patient. If such a lens is suspended by the remaining zonules at the su...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(01)01167-1
更新日期：2002-06-01 00:00:00
abstract：PURPOSE:To determine the level of residual spherical aberration that gives the best objective and subjective quality of image after cataract surgery with intraocular lens (IOL) implantation. SETTING:Department of Ophthalmology, CHU Bretonneau, Tours, France. DESIGN:Cohort study. METHODS:Six months after microincisio...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2010.12.056
更新日期：2011-06-01 00:00:00
abstract：:Members of the ASCRS Cornea Clinical Committee performed a review of the current literature on the corneal crosslinking (CXL) procedure for treating corneal ectasia. The members explored the data on the techniques currently in use and under investigation, including their advantages, safety profiles, risks, and cost an...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,评审
doi：10.1016/j.jcrs.2019.06.027
更新日期：2019-11-01 00:00:00
abstract：PURPOSE:To assess the efficacy of deep anterior lamellar keratoplasty (DALK) for treating post-LASIK keratectasia. SETTING:Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. DESIGN:Retrospective interventional cases series. METHODS:The same surgeon performed all DALK procedures using ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2014.04.029
更新日期：2014-12-01 00:00:00
abstract：:Twenty-eight epikeratophakia procedures have been performed at the University of Minnesota since December 1985. This report describes several technique modifications and compares the refractive and visual outcome of these cases with the national results. There have been 17 aphakic cases (13 adult and four pediatric), ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(89)80091-4
更新日期：1989-05-01 00:00:00
abstract：PURPOSE:To characterize and compare the higher-order aberrations (HOAs) in 3 intraocular lenses (IOLs) designed to minimize HOAs using a new physical model eye. SETTING:Department of Ophthalmology, University of Auckland, New Zealand. METHODS:Measurements of higher-order wavefront aberrations were obtained using the ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2008.11.048
更新日期：2009-03-01 00:00:00
abstract：PURPOSE:To estimate the ability of the Ocular Response Analyzer parameters to aid in the diagnosis of keratoconus in pre-laser in situ keratomileusis (LASIK) patients. SETTING:Department of Ophthalmology, Bordeaux 2 University, Bordeaux Cedex, France. DESIGN:Evaluation of diagnostic test. METHODS:This study compared...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2011.06.029
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:To evaluate whether intracameral triamcinolone has an effect on anterior segment inflammation and visual axis obscuration after pediatric cataract surgery with intraocular (IOL) implantation. SETTING:Iladevi Cataract and IOL Research Institute, Ahmedabad, India. METHODS:This retrospective age-matched case-con...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2010.03.040
更新日期：2010-09-01 00:00:00
abstract：PURPOSE:To assess the outcomes of intrastromal ring segment (Intacs, Addition Technology) implantation for keratoconus using the femtosecond laser. SETTING:Kudret Eye Hospital, Ankara, Turkey. METHODS:In a retrospective noncomparative case series, 118 eyes of 69 patients with keratoconus who had Intacs segments impla...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2006.08.032
更新日期：2006-12-01 00:00:00
abstract：PURPOSE:To study the microanatomic edge structures of anterior lens capsule specimens derived from manual and femtosecond laser-assisted capsulotomies. SETTING:Department of Ophthalmology, Goethe-University, Frankfurt, Germany. DESIGN:Experimental study. METHODS:Of 60 eyes with lens removal and intraocular lens impl...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2013.07.024
更新日期：2013-10-01 00:00:00
abstract：UNLABELLED:A 22-year-old white man presented with photopsia of 3-year duration despite a corrected distance visual acuity of 20/20 in both eyes. Ophthalmic examination revealed multiple irregularly shaped white cortical opacifications of the lens in both eyes but no other significant ocular findings. One year after the...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2016.06.007
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:To find the incidence, contributing factors, outcomes, and clinical impact of intraoperative posterior capsule striae. SETTING:Iladevi Cataract & IOL Research Centre, Ahmedabad, India. METHODS:In a prospective study, 100 consecutive eyes had phacoemulsification and intraocular lens (IOL) (AcrySof MA30BA) impl...
journal_title：Journal of cataract and refractive surgery
pub_type： 临床试验,杂志文章
doi：10.1016/s0886-3350(99)00197-2
更新日期：1999-11-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy, predictability, stability, and complications after implantation of a foldable iris-fixated toric phakic intraocular lens (pIOL) to correct myopic astigmatism. SETTING:University Eye Clinic, Paracelsus Medical University, Salzburg, Austria. DESIGN:Retrospective nonrandomized observati...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2011.11.027
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:To determine whether the yellow filters often used for glare reduction influence retinal straylight measured in healthy eyes. SETTING:Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium. DESIGN:Prospective case series. METHODS:For each eye, the spherical equivalent (SE) was determined u...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2017.06.033
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:To study the effect of primary posterior capsulotomy with anterior vitrectomy (PPC + AV) and intraocular lens (IOL) design and material on the development of posterior capsule opacification (PCO) after pediatric cataract surgery. SETTING:Tertiary care institution in India. PATIENTS:Sixty-four eyes of 52 child...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(03)00231-1
更新日期：2003-08-01 00:00:00
abstract：PURPOSE:To compare the outcomes of combined cataract surgery with trabecular microbypass stents and ab interno trabeculotomy in patients with open-angle glaucoma. SETTING:University of Toronto, Toronto, Ontario, and University of Montreal, Montreal, Quebec, Canada, and Glaucoma Associates of Texas, Dallas, Texas, USA....
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2014.12.061
更新日期：2015-08-01 00:00:00
abstract：:I describe an intraoperative method for the consistent anchoring of the intraocular lens (IOL) and cataract surgery and on the patient's visual axis using coaxial microscope optics, surgeon-guided patient fixation, the precision pulse capsulotomy (PPC) device (Zepto) and utilizing the first (and fourth) Purkinje image...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2018.02.013
更新日期：2018-05-01 00:00:00
abstract：UNLABELLED:Left ventricular assist devices (LVADs) have been increasingly used for 20 years in terminally ill patients with advanced heart failure or awaiting cardiac transplantation. Despite improvement in morbidity and mortality from use of these devices, quality of life may be limited by cataract. Access to cataract...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2014.01.024
更新日期：2014-04-01 00:00:00
