Abstract:
PURPOSE:To assess the safety and effectiveness of an immunotoxin, MDX-RA, designed to inhibit posterior capsule opacification (PCO). SETTING:Eleven private practices in the United States. METHODS:This study comprised 63 eyes of 63 patients having extracapsular cataract extraction by phacoemulsification; these patients were enrolled in a Phase I/II clinical investigation of the immunotoxin MDX-RA. At the close of surgery, 21 patients were treated with placebo, 23 patients with 50 units of the immunotoxin, and 19 patients with 175 units of the immunotoxin as an aqueous solution. The patients were monitored for 24 months after primary cataract surgery using external eye and slitlamp examinations, visual acuity assessment, ophthalmoscopy, pachymetry, tonometry, endothelial cell counts, and lens capsule photography. Posterior capsule opacification, recorded on lens capsule photographs, was graded independently by a committee of 3 cataract surgeons. The incidence of neodymium:YAG (Nd:YAG) capsulotomy was projected from the opacification results. RESULTS:The immunotoxin, at the 50 unit dose, was well tolerated and effective in inhibiting PCO. At the 175 unit dose, there was a trend toward increased postoperative inflammation that was transient with no residua. From 6 to 24 months postoperatively, the 50 unit dose significantly inhibited PCO compared with the placebo (P < .05). This significant reduction in PCO translated into a significantly lower projected need for Nd:YAG capsulotomy in the 50 unit than the placebo group (P < .004). About 60% in the placebo group and 4% in the 50 unit group were projected to need an Nd:YAG capsulotomy by 3 years postoperatively. CONCLUSION:The immunotoxin was well tolerated and was effective in reducing PCO for up to 24 months after cataract surgery. Although these preliminary results are encouraging, a larger study is underway to determine whether the reduction in PCO by the immunotoxin decreases the need for Nd:YAG capsulotomy.
journal_name
J Cataract Refract Surgjournal_title
Journal of cataract and refractive surgeryauthors
Clark DS,Emery JM,Munsell MFdoi
10.1016/s0886-3350(98)80352-0subject
Has Abstractpub_date
1998-12-01 00:00:00pages
1614-20issue
12eissn
0886-3350issn
1873-4502pii
S0886-3350(98)80352-0journal_volume
24pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract::We report a case in which the capsular bag with an intraocular lens (IOL) and a capsular tension ring (CTR) dislocated into the vitreous. The dislocated foldable posterior chamber IOL and CTR were removed with a pars plana vitrectomy and exchanged with a scleral-fixated IOL. No complications occurred intraoperatively ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2006.05.016
更新日期:2006-10-01 00:00:00
abstract::The optical resolution and contrast of 18 silicone and 18 polymethylmethacrylate (PMMA) intraocular lenses were determined before implantation in and after removal from rabbit eyes. A specially designed microphotographic system that allows documentation and comparison of the image quality of different lens types was u...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(87)80153-0
更新日期:1987-11-01 00:00:00
abstract::A randomized prospective trial compared keratometric and visual outcomes for 196 patients receiving 3.2 mm, 5.0 mm, or 6.0 mm incisions for cataract removal and intraocular lens implantation. There were no statistically significant differences among the groups preoperatively or at one to two days or three to six month...
journal_title:Journal of cataract and refractive surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0886-3350(13)80402-6
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:To compare the incidence and severity of photic phenomena after the implantation of the Array(R) (Allergan) refractive multifocal intraocular lens (MIOL) and a monofocal IOL. SETTING:Multicenter study at Kiel, Mainz, Karlsruhe, and Bremerhaven, Germany. METHODS:The study comprised 231 randomly selected patien...
journal_title:Journal of cataract and refractive surgery
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0886-3350(00)00540-x
更新日期:2001-02-01 00:00:00
abstract:UNLABELLED:We describe a technique for sutureless intrascleral fixation of a 3-piece intraocular lens (IOL) and custom silicone iris prosthesis complex to address the optical and functional issues of aphakia and aniridia, as well as to restore excellent cosmesis. The 3-piece IOL is anchored to the iris prosthesis using...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2014.09.015
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:To determine whether sutureless small incision cataract surgery reduces induced astigmatism over the long term. SETTING:University Eye Hospital, Vienna, Austria. METHODS:In a prospective study, we investigated surgically induced astigmatism in 63 cases of no-stitch, small incision cataract surgery with a 4.0 ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(97)80180-0
更新日期:1997-04-01 00:00:00
abstract:PURPOSE:To report the incidence, pathogenesis, and management of pupillary capture after combined phacoemulsification with intraocular lens (IOL) implantation and vitreoretinal surgery. SETTING:Oxford Eye Hospital, The Radcliffe Infirmary, Oxford, United Kingdom. METHODS:This retrospective case review comprised 12 pa...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(02)01212-9
更新日期:2002-09-01 00:00:00
abstract::We report two cases in which hydrogel lens implants have dislocated posteriorly into the vitreous body following YAG laser capsulotomy. These lenses were placed in the bag in conjunction with a capsulorhexis. A comparison with our results using silicone and poly(methyl methacrylate) implants indicates that this phenom...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(13)80770-5
更新日期:1990-09-01 00:00:00
abstract::We examined the use of a geometric model to explain the effects of radial keratotomy (RK) on corneal topography based on wound gape of radial incisions. Histopathologic studies of healed human RK incisions revealed incision gape in Bowman's membrane and anterior stroma, with intervening epithelial ingrowth or fibrous ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(13)80850-4
更新日期:1991-07-01 00:00:00
abstract::We describe a technique for stromal expansion of thin and ultrathin corneas in keratoconus patients that uses refractive stromal lenticules of patients having small-incision lenticule extraction for myopic correction. The stromal lenticule is placed and spread over the host cornea following epithelial debridement so t...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2015.04.007
更新日期:2015-05-01 00:00:00
abstract:PURPOSE:To evaluate the intraoperative difficulties and long-term outcome of phacoemulsification through a small pupil using minimal iris manipulation. SETTINGS:Iladevi Cataract & IOL Research Centre, Ahmedabad, India. METHODS:This prospective study included 30 consecutive eyes with a maximally dilated pupil size of ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(00)00361-8
更新日期:2000-08-01 00:00:00
abstract:PURPOSE:To evaluate the 12-month U.S. phase II clinical trial results of the Crystalens AT-45 (eyeonics, Inc.) intraocular lens (IOL) used to provide uncorrected distance, intermediate, and near visual acuities in patients having cataract extraction and to compare in a substudy the contrast sensitivity and near visual ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jcrs.2006.02.007
更新日期:2006-05-01 00:00:00
abstract:PURPOSE:To evaluate the influence of a capsular bending ring (CBR) or tension ring (CTR) on capsular bag shrinkage. SETTING:Department of Ophthalmology, Johannes Gutenberg-University, and Department of Medical Biometry, Epidemiology and Informatics, University of Mainz, Mainz, Germany. METHODS:In 92 eyes of 92 patien...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jcrs.2005.06.046
更新日期:2005-10-01 00:00:00
abstract::A 76-year-old woman had sudden visual loss 9 years after an extracapsular cataract extraction with implantation of a poly(methyl methacrylate) disc intraocular lens (IOL) in the capsular bag. Slitlamp examination showed the disc IOL had luxated into the vitreous through a linear inferior opening in the capsular bag; t...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(99)80142-4
更新日期:1999-02-01 00:00:00
abstract:PURPOSE:To test the accuracy and reliability of the first-generation prototype of Tracey-1, a ray-tracing refractometer. SETTING:Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA. METHODS:The refractive spherical equivalent (SE) and astigmatism measured by Tracey-1, subjective manifest refraction ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(01)01103-8
更新日期:2002-02-01 00:00:00
abstract:PURPOSE:To compare two standard small incision techniques for cataract surgery--clear corneal incision and sclerocorneal incision--with regard to postoperative disturbance of the blood-aqueous barrier (BAB). SETTING:Department of Ophthalmology, University of Vienna, Austria. METHODS:This prospective comparative study...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(98)80296-4
更新日期:1998-04-01 00:00:00
abstract:UNLABELLED:We report a case in which toric intraocular Collamer lenses (ICLs) effectively corrected the refractive errors of pellucid marginal degeneration (PMD). Preoperatively, in the patient's right eye, the manifest refraction was -10.5 -3.5 x 55, the uncorrected distance visual acuity (UDVA) was 20/1000, and the c...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2009.08.021
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:To evaluate surgically induced corneal astigmatism after small superotemporal and superonasal clear corneal incision cataract surgery. SETTING:Department of Ophthalmology, School of Medicine, University of Afyon Kocatepe, Afyon, Turkey. METHODS:This prospective study comprised 56 eyes of 28 patients who had b...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2003.11.034
更新日期:2004-06-01 00:00:00
abstract::We evaluated two topical cyclo-oxygenase inhibitors (COIs), 0.03% flurbiprofen and 1% indomethacin, for their ability to prevent pseudophakic cystoid macular edema (CME). The study was a randomized, double-masked, vehicle-controlled, parallel group, clinical trial for six months at eight sites in Canada and two in Ger...
journal_title:Journal of cataract and refractive surgery
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0886-3350(13)80484-1
更新日期:1995-01-01 00:00:00
abstract::This paper describes a surgical training system for teaching and practicing the necessary skills to perform phacoemulsification, endocapsular phacoemulsification, and small incision intraocular lens insertion techniques. The surgical system includes head, bilateral globes, removable corneas, and replaceable synthetic ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(88)80100-7
更新日期:1988-03-01 00:00:00
abstract::A 66-year-old Chinese man developed corneal endothelial decompensation after intraocular lens (IOL) repositioning using intracameral epinephrine was performed. The presentation was compatible with toxic endothelial cell destruction syndrome, which is caused by prolonged, direct exposure of the corneal endothelium to r...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2008.05.059
更新日期:2008-11-01 00:00:00
abstract:PURPOSE:To compare the postoperative outcomes between femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification in eyes with shallow anterior chamber depth (ACD). SETTING:Eye Clinic, NEUROFARBA Department, University of Florence, Italy. DESIGN:Prospective case series. METHODS:Forty eye...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1097/j.jcrs.0000000000000341
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:To compare the outcomes of mechanical and femtosecond laser-assisted tunnel creation for intrastromal corneal ring segment (ICRS) implantation in eyes with keratoconus. SETTING:Kartal Training and Research Hospital, Istanbul, Turkey. METHODS:In this prospective study, consecutive eyes with keratoconus were ra...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jcrs.2010.04.028
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:To evaluate a poly(methyl methacrylate) refractive, zonal-progressive multifocal intraocular lens (IOL) in patients requiring cataract surgery. SETTING:Department of Ophthalmology, Saiseikai Kurihashi Hospital, Saitama, Japan. METHODS:This open-label noncomparative study evaluated 58 eyes of 31 Japanese patie...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(99)00408-3
更新日期:2000-07-01 00:00:00
abstract::A monolayer of proliferating lens epithelium on the anterior surface of an intraocular lens was found cytologically and confirmed histologically in a postmortem examination of one eye of a 57-year-old man. The man had had extracapsular cataract surgery five years earlier. This pathological finding confirms observation...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(13)80353-7
更新日期:1993-11-01 00:00:00
abstract::Subluxated cataractous and clear lenses are commonly treated by limbal or pars plana lensectomy followed by primary or secondary intraocular lens (IOL) implantation. Adjunctive capsular prosthetic devices have facilitated lens removal and IOL centration in these challenging cases but have also added complexity and pot...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2009.05.019
更新日期:2009-10-01 00:00:00
abstract:PURPOSE:To evaluate and compare the predictability and safety of immediate small-incision lenticule extraction, also known as SMILE, after suction loss during the procedure with those of uneventful small-incision lenticule extraction. SETTING:Nunemiso Eye Center, Seoul, South Korea. DESIGN:Retrospective case series. ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2016.12.034
更新日期:2017-04-01 00:00:00
abstract::We present a case of traumatic lens subluxation that was evident only when the patient was in the supine position. This case illustrates that a crystalline lens with traumatic zonular rupture can change its position depending on the posture of the patient. If such a lens is suspended by the remaining zonules at the su...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(01)01167-1
更新日期:2002-06-01 00:00:00
abstract::A generally healthy and independent 83-year-old man presented with long-standing, mild to moderate glaucoma. He had uneventful cataract surgery several years earlier. He also had previous selective laser trabeculoplasty (SLT) with only slight reduction in his intraocular pressure (IOP). His untreated IOP was middle to...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1097/j.jcrs.0000000000000244
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:To theoretically compare the corneal stress distribution of laser in situ keratomileusis (LASIK) with the stress distribution of small-incision lenticule extraction. SETTING:Cleveland Clinic Cole Institute, Cleveland, and The Ohio State University, Columbus, Ohio, USA. DESIGN:Computational modeling study. ME...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2013.08.065
更新日期:2014-06-01 00:00:00