Abstract:
BACKGROUND:Antidepressant medications have long been implicated as a cause of falls in older people, but there are few data on the risk of falls associated with exposure to serotonin-norepinephrine (noradrenaline) reuptake inhibitors (SNRIs). OBJECTIVE:The aim of this study was to determine the role of SNRIs in older people with a recorded fall in primary care using a case-control approach and a self-controlled case-series analysis of data from The Health Improvement Network (THIN) UK primary care database. METHODS:Cases were 9862 individuals aged >60 years with a first fall recorded between 2003 and 2006. Up to six controls per case were matched by age, sex and primary care practice. For the case-series analysis, we extended our case set to those with a first fall recorded between 2001 and 2008. We estimated odds ratios (ORs) for 'ever', 'current', 'recent', 'previous' or 'never' prescribed SNRIs (and for the other main classes of antidepressants, for comparison) in cases compared with matched controls, using conditional logistic regression. We also examined the effect of the time interval from first prescription to first fall. In the case-series analysis, we compared the rate of occurrence of first falls during episodes of exposure to SNRIs with unexposed periods in our case group. RESULTS:There was an increased risk of current prescribing of SNRIs (adjusted OR 1.79; 95% CI 1.42, 2.25) in first fall cases compared with controls. This was similar in magnitude to that seen with tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs). The increase in risk was apparent within the first 28 days after first prescription. The effects were also apparent in the self-controlled case-series analysis, although the magnitudes of effect were slightly smaller; the incidence risk ratio for the period 1-28 days after initiation of treatment compared with unexposed periods was 1.49 (95% CI 1.15, 1.93). CONCLUSIONS:Treatment with SNRIs in older people may be associated with an increased risk of falling. The falls risk profile of SNRIs appears to be similar to that of SSRIs and TCAs.
journal_name
Drugs Agingjournal_title
Drugs & agingauthors
Gribbin J,Hubbard R,Gladman J,Smith C,Lewis Sdoi
10.2165/11592860-000000000-00000subject
Has Abstractpub_date
2011-11-01 00:00:00pages
895-902issue
11eissn
1170-229Xissn
1179-1969pii
4journal_volume
28pub_type
杂志文章相关文献
DRUGS & AGING文献大全abstract:BACKGROUND:Frailty is a clinical phenotype that is associated with adverse health outcomes. Since frail patients may be more prone for adverse drug events and about 15-20 % of commonly prescribed drugs are metabolized by CYP2D6, we hypothesized that CYP2D6 metabolism is decreased in frail patients compared with healthy...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-015-0319-0
更新日期:2015-12-01 00:00:00
abstract::Cataract surgery is the most frequent surgical procedure requiring anaesthesia in developed countries. It is performed mainly in elderly patients, who present with many coexisting diseases that induce subsequent hazards from general anaesthesia. Cataract anaesthesia is performed following various techniques of regiona...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11318590-000000000-00000
更新日期:2010-01-01 00:00:00
abstract::Although use of NSAIDs and aspirin (acetylsalicylic acid) is well known to be associated with gastrointestinal (GI) complications and potential mortality, these medications continue to be widely prescribed in the elderly. Age is a significant risk factor for NSAID-induced GI events; indeed, patients >75 years of age c...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200724020-00004
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Previous studies have investigated the prevalence of drug-drug interactions (DDIs) among the elderly in different care settings, but data describing the frequency and management of DDIs among acute geriatric patients appear to be absent. OBJECTIVE:The aim of this study was to investigate the severity and in...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-013-0091-y
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Older people often take multiple medications. It is a policy priority to facilitate older people to stay at home longer. Three-quarters of nursing home placements in the US are preceded by a hospitalization. OBJECTIVE:To investigate the association between polypharmacy and medication regimen complexity with...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-014-0185-1
更新日期:2014-08-01 00:00:00
abstract::The 2013 American College of Cardiology (ACC) and American Heart Association (AHA) practice guidelines for the treatment of blood cholesterol significantly changed the paradigm of how providers should prescribe statin therapy, especially for older adults. While the evidence supports statin therapy for older adults wit...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-014-0238-5
更新日期:2015-02-01 00:00:00
abstract::Nitric oxide (NO) is involved in important physiological functions of the CNS, including neurotransmission, memory and synaptic plasticity. Depending on the redox state of NO, it can act as a neurotoxin or it can have a neuroprotective action. Data suggest that NO may have a role in the pathogenesis of neurodegenerati...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199812040-00001
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Inappropriate prescribing is an important and possibly preventable risk factor for adverse drug reactions (ADRs) in the elderly, and hospital-based studies have shown that a large proportion of admissions is a result of ADRs. However, little is known about how inappropriate drug use (IDU) affec...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200522010-00005
更新日期:2005-01-01 00:00:00
abstract::The atypical antipsychotics are a new class of agents with great promise for use in the elderly because of their reduced propensity to cause acute extrapyramidal adverse effects. Treatment of older patients with these agents, however, needs to take into consideration age-related changes in pharmacokinetics and the ris...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199812020-00004
更新日期:1998-02-01 00:00:00
abstract::Atrial fibrillation confers a 5-fold increase in risk of stroke. A number of drugs aimed at reducing this risk have been tested in randomized controlled trials. These include antiplatelet agents (singly and in combination); anticoagulants, including vitamin K antagonists and direct thrombin inhibitors; and anticoagula...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11538620-000000000-00000
更新日期:2010-11-01 00:00:00
abstract::Many quantities assayed in clinical laboratories demonstrate age-related changes. Particularly important periods are early life, adolescence, old age, and after the menopause in females. The changes that occur until adulthood are well documented. Fewer data are available on elderly people even though they consume a la...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199303030-00006
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Statins have been shown to be beneficial in primary and secondary prevention settings; however, their role in the elderly remains a clinical conundrum, given that age-related factors could alter the risk-benefit ratio of statin treatment. This study aimed to critically evaluate the efficacy and safety of sta...
journal_title:Drugs & aging
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s40266-015-0290-9
更新日期:2015-08-01 00:00:00
abstract::Hyperuricaemia is an independent risk factor for renal function decline. Evidence is emerging that urate-lowering therapy might be beneficial in subjects with renal impairment. We review the association between renal impairment and gout, some of the related pathogenic processes and the possible impact of gout treatme...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-018-0517-7
更新日期:2018-04-01 00:00:00
abstract::Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting 1 to 3% of individuals over the age of 65 years. While effective therapy exists for treating the bradykinesia, rigidity and tremor associated with the disease, the cause is unknown. There is no treatment available to prevent or slo...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200118110-00001
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The practice of hiding medicines in nursing home patients' food or beverages is described in only a few scientific papers. An earlier study conducted in 1999/2000 showed that covert medication was common in Norwegian nursing homes, with 11% of patients in regular nursing home units (RUs) and 17...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/00002512-200926040-00004
更新日期:2009-01-01 00:00:00
abstract::Spasticity following stroke reflects a spectrum of clinical problems including increased muscle tone, abnormal limb posture, excessive contraction of antagonist muscles and hyperactive cutaneous and tendon reflexes. The prevalence of stroke-related disability in stroke survivors is high, and spasticity may be a signif...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199609050-00004
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVE:To assess, by smoothness index (SI), distribution of the antihypertensive effect of extended-release (ER) felodipine over 24 hours in elderly patients with hypertension. METHODS:After a 4-week washout phase, 35 elderly patients (mean age 69 +/- 4 years) with mild-to-moderate hypertension received 2 weeks' tr...
journal_title:Drugs & aging
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2165/00002512-200219070-00007
更新日期:2002-01-01 00:00:00
abstract::Asthma is a common airway disease found in people of all ages, although most studies of asthma therapies are focused on adolescent and young adults. Little information exists on the use of asthma therapeutics in the older patient (>65 years of age). The newest therapeutic class to be released in the US for the treatme...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200623060-00002
更新日期:2006-01-01 00:00:00
abstract::There has been a growing recognition that pulsatile stimulation of dopamine receptors may be an important mechanism in the generation of the motor fluctuations that often develop and compromise the effectiveness of long-term levodopa administration in persons with Parkinson's disease (PD). This has prompted investigat...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200219080-00002
更新日期:2002-01-01 00:00:00
abstract::We conducted a review of drugs that were most commonly associated with inducing seizures in the elderly population. The method for determining the risk of these agents includes evaluating the utilisation and the percentage of adverse events in previous studies and case reports. Classes of medications, such as anti-psy...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199507010-00005
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVE:To review the influence of age on the response of patients with idiopathic thrombocytopenic purpura (ITP) to corticosteroids, splenectomy and danazol. METHODS:We retrospectively reviewed a cohort of 139 consecutively treated patients with ITP diagnosed between 1985 and 1994. In particular, we analysed the th...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200320110-00005
更新日期:2003-01-01 00:00:00
abstract::The incidence of prostate carcinoma in the US now appears to be declining slightly, as a consequence of removal of prevalent cases from the population by screening. Screening for serum prostate-specific antigen (PSA) levels has been improved by the use of PSA transformations including PSA density, PSA velocity and age...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199813010-00007
更新日期:1998-07-01 00:00:00
abstract::Xerostomia and salivary gland hypofunction (SGH) are prevalent in elderly populations, causing much discomfort and even difficulties in eating. SGH also increases the occurrence and severity of oral diseases and makes the patient susceptible to candidiasis. The principal causes of SGH and xerostomia are systemic disea...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199915020-00004
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Pharmacotherapy with statins (HMG-CoA reductase inhibitors) is the cornerstone for lipid management in individuals with or at risk of developing cardiovascular diseases. Although the clinical benefits of statins are established for both women and men, there is evidence of a gender difference in their use. Th...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-012-0032-1
更新日期:2012-12-01 00:00:00
abstract::Influenza is a major cause of morbidity and mortality in the elderly. Influenza vaccine is recommended for people aged 65 years and older and those in long term care. Currently only 30% of high risk persons are vaccinated. Vaccination generally stimulates an adequate immune response, is well tolerated and is to be enc...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199101060-00003
更新日期:1991-11-01 00:00:00
abstract::Gout in older patients tends to be sub-acute to chronic, often tophaceous, polyarticular, erosive, symmetrical, and causes persistent, recurrent and chronic arthritis. Clinically, it may closely mimic rheumatoid arthritis; thus, a correct diagnosis requires a high index of clinical suspicion and the identification of ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199404020-00005
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Limited data are available on the prevalence of inappropriate prescribing of renally cleared drugs in elderly patients in Australia. OBJECTIVES:To quantify and compare the extent of inappropriate prescribing (defined as at least one drug prescribed in an excessive dose or when contraindicated with respect t...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-015-0261-1
更新日期:2015-05-01 00:00:00
abstract::The Medicare programme already funds a large proportion of the medical care for older Americans. However, geriatricians are an underutilized resource for improving the quality of care delivered with Medicare funding, particularly to the most complex patients. Recent legislative changes will increase the involvement of...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200522050-00002
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Potentially inappropriate medications (PIMs) are defined by the American Geriatric Society as medications that should be avoided in the elderly in general, or in specific situations. However, PIM use remains high among aging populations and may result in increased utilization of healthcare resources. OBJECT...
journal_title:Drugs & aging
pub_type: 杂志文章,meta分析
doi:10.1007/s40266-020-00770-1
更新日期:2020-07-01 00:00:00
abstract::Chronic non-terminal diseases, including postmenopausal osteoporosis, are associated with poor treatment compliance and persistence. The longer a patient with osteoporosis complies and persists with treatment, the lower the risk of fracture. Retrospective studies with emphasis on real-world data have led to a greater ...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11586880-000000000-00000
更新日期:2011-04-01 00:00:00