Abstract:
BACKGROUND:Previous studies have investigated the prevalence of drug-drug interactions (DDIs) among the elderly in different care settings, but data describing the frequency and management of DDIs among acute geriatric patients appear to be absent. OBJECTIVE:The aim of this study was to investigate the severity and interdisciplinary management of DDIs in patients admitted to an acute geriatric ward. METHODS:The study was conducted at Oslo University Hospital, Norway, over a period of 19 weeks in 2010/11. On admission and daily during the hospital stay, prescribed medications were reviewed by pharmacists to identify DDIs with the aid of web-based databases. DDIs defined to be of potential clinical relevance, i.e., those classified as "major" (generally avoid) or "moderate" (precautions recommended), were following assessments by pharmacists presented at interdisciplinary meetings with geriatricians and nurses, and discussed in relation to the possible implementation of monitoring actions or changes in prescribing. The odds for prescribing changes were compared in relation to DDI type ("pharmacokinetic" vs. "pharmacodynamic") and severity ("major" vs. "moderate"). The project group retrospectively assessed the possible causal relationships between hospitalizations and DDIs. RESULTS:The pharmacists identified 245 DDIs of major (n = 13) or moderate (n = 232) severity in 80 (63.5 %) of the 126 patients included on admission and/or during hospitalization. In 94 of 162 cases where the pharmacists alerted the geriatricians (58.0 %), prescribing changes or monitoring actions were implemented. Prescribing changes (n = 38) were performed significantly more often for major than for moderate DDIs [odds ratio (OR) 3.8; 95 % confidence interval (CI) 1.2-12.2, p = 0.03], and significantly more often for pharmacokinetic than for pharmacodynamic DDIs (OR 4.9; 95 % CI 2.2-10.9, p < 0.01). For 28 of 126 patients (22.2 %), a causal relationship between hospitalizations and DDIs was assessed as "possible". CONCLUSIONS:The present study shows that acute geriatric patients are frequently exposed to DDIs for which active management is recommended in order to avoid unfavorable clinical outcomes. The integration of pharmacists into interdisciplinary teams could prevent potentially severe DDIs in the elderly.
journal_name
Drugs Agingjournal_title
Drugs & agingauthors
Lea M,Rognan SE,Koristovic R,Wyller TB,Molden Edoi
10.1007/s40266-013-0091-ysubject
Has Abstractpub_date
2013-09-01 00:00:00pages
721-7issue
9eissn
1170-229Xissn
1179-1969journal_volume
30pub_type
杂志文章相关文献
DRUGS & AGING文献大全abstract::Multiple sclerosis (MS) is an acquired inflammatory demyelinating disease of the CNS that is typically diagnosed in the second or third decade of life. It is generally believed that over the last few decades the life expectancy of patients with adult onset MS (AOMS) has approached that of the general population as a r...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11532120-000000000-00000
更新日期:2010-04-01 00:00:00
abstract::Disease-modifying antirheumatic drugs (DMARDs) are frequently used in rheumatoid arthritis. A number of physiological changes occur in the elderly which may modify the use of these medications. The most commonly used DMARDs are antimalarial drugs (particularly hydroxychloroquine), sulfasalazine and methotrexate. The p...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199507060-00003
更新日期:1995-12-01 00:00:00
abstract::Influenza causes substantial morbidity across the age spectrum. However, the elderly are especially vulnerable to the serious complications of influenza that might result in hospitalisation or death, and high rates of influenza-associated excess hospitalisation or death that exceed by several-fold the rates seen among...
journal_title:Drugs & aging
pub_type: 杂志文章,meta分析,评审
doi:10.2165/00002512-200522060-00004
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Medication-related admissions are an important cause of hospital admissions in older people. The scope for prevention is less clear. OBJECTIVES:To characterize medication-related hospital admissions in older people and assess their preventability. METHODS:This was a cross-sectional, observational study con...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11316750-000000000-00000
更新日期:2009-01-01 00:00:00
abstract::Cataract surgery is the most frequent surgical procedure requiring anaesthesia in developed countries. It is performed mainly in elderly patients, who present with many coexisting diseases that induce subsequent hazards from general anaesthesia. Cataract anaesthesia is performed following various techniques of regiona...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11318590-000000000-00000
更新日期:2010-01-01 00:00:00
abstract::Neuropathic pain (NeP) is a significant medical and socioeconomic burden with limited therapeutic options. Elderly patients exhibit a higher incidence of several NeP conditions and pose a particular challenge due to age-related pharmacokinetic and pharmacodynamic issues, comorbid conditions, and polypharmacy, as well ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-014-0218-9
更新日期:2014-12-01 00:00:00
abstract::The management of type 2 diabetes mellitus in older adults requires a comprehensive understanding of the relationship between the disease (medical) and the functional, psychological/cognitive, and social geriatric domains, to individualize both glycemic targets and therapeutic approaches. Prevention of hypoglycemia is...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-019-00706-4
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Prescription sleep medications are often utilized to manage sleep problems among older adults even though these drugs are associated with multiple risks. OBJECTIVE:The aim was to determine the prevalence and characteristics of new-onset compared to chronic sleep medication users and to examine factors assoc...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-018-0543-5
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:There is poor evidence supporting the use of any pharmacologic treatments for neuropsychiatric disorders following traumatic brain injury (TBI), especially among older adults. Informed by our recent characterization of psychotropic medication use among Medicare beneficiaries with TBI, the objective of this st...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-018-0570-2
更新日期:2018-08-01 00:00:00
abstract::Blood pressure levels are strongly predictive of the risks of first-ever and recurrent stroke. The benefits of blood pressure-lowering therapy for the prevention of fatal and non-fatal stroke in middle-aged individuals are well established. However, until recently, there has been uncertainty about the consistency of s...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200320040-00001
更新日期:2003-01-01 00:00:00
abstract::Extended-release oxybutynin (Ditropan XL) uses an osmotic system (OROS) to deliver a controlled amount of oxybutynin chloride into the gastrointestinal tract over a 24-hour period when taken once daily. Oxybutynin binds to M3 muscarinic receptors on the detrusor muscle of the bladder, preventing acetylcholinergic acti...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200016020-00008
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Home care (HC) patients are characterized by a high level of complexity, which is reflected by the prevalence of multimorbidity and the correlated high drug consumption. This study assesses prevalence and factors associated with polypharmacy in a sample of HC patients in Europe. METHODS:We conducted a cross...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.1007/s40266-018-0521-y
更新日期:2018-02-01 00:00:00
abstract::Electronic storage of and access to medical data is becoming increasingly common. Advances in computer technology and telecommunications have made it possible to store vast amounts of information in databases and transmit this information rapidly to any place on the globe. At the forefront of this technology is the In...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199710030-00001
更新日期:1997-03-01 00:00:00
abstract::Large bowel cancer is not only the third most frequent cancer in the world but is one of the most common human malignancies in Western countries, including North America. In recent years, multidisciplinary research in epidemiology, molecular biology, and laboratory animal model studies have contributed much to our und...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200016050-00002
更新日期:2000-05-01 00:00:00
abstract::There has been a growing recognition that pulsatile stimulation of dopamine receptors may be an important mechanism in the generation of the motor fluctuations that often develop and compromise the effectiveness of long-term levodopa administration in persons with Parkinson's disease (PD). This has prompted investigat...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200219080-00002
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:For physicians dealing with patients with a limited life expectancy, knowing the time to benefit (TTB) of preventive medication is essential to support treatment decisions. OBJECTIVE:The aim of this study was to investigate the usefulness of statistical process control (SPC) for determining the TTB in relat...
journal_title:Drugs & aging
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40266-016-0344-7
更新日期:2016-05-01 00:00:00
abstract::Vitreous haemorrhage can be caused by a disruption of normal retinal vessels, bleeding from diseased retinal vessels, bleeding from abnormal new vessels or extension of haemorrhage through the retina from other sources. In the elderly, vitreous haemorrhage usually occurs spontaneously and only occurs occasionally as a...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200320090-00003
更新日期:2003-01-01 00:00:00
abstract::Influenza infection is an acute respiratory disease with a high morbidity and significant mortality, particularly among the elderly and individuals with chronic diseases. The majority of countries now recommend annual influenza vaccination for all people aged 65 years or older, and for those with high risk conditions....
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199915030-00001
更新日期:1999-09-01 00:00:00
abstract::Primary hyperparathyroidism is a common metabolic bone disease and currently presents a significant management dilemma. Most of the patients have few relevant symptoms and surgical parathyroidectomy offers the prospect of cure with freedom from the risk of long-term complications or the need for a follow-up. However, ...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-200421150-00004
更新日期:2004-01-01 00:00:00
abstract::Lithium salts have a well-established role in the treatment of major affective disorders. More recently, experimental and clinical studies have provided evidence that lithium may also exert neuroprotective effects. In animal and cell culture models, lithium has been shown to increase neuronal viability through a combi...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11599180-000000000-00000
更新日期:2012-05-01 00:00:00
abstract::Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide and is characterised by cardinal clinical features and specific pathological findings. It is possible to detect PD early on in the course of the disease, and certain laboratory studies may identify preclinical stages. Based on this...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199609030-00002
更新日期:1996-09-01 00:00:00
abstract::Unfortunately the sections were published incorrectly in the original article. ...
journal_title:Drugs & aging
pub_type: 已发布勘误
doi:10.1007/s40266-020-00807-5
更新日期:2020-11-01 00:00:00
abstract::Prostate cancer is a common disease in the elderly, and the number of older prostate cancer patients will probably increase with both the aging of the population and the increased rate of screening. In elderly patients with several co-morbidities, cancer management can be complex, and the risk of administering toxic t...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/11537480-000000000-00000
更新日期:2010-09-01 00:00:00
abstract::The number of older patients is increasing globally. Combined with the growing number of ambulatory surgeries, many older patients will undergo ambulatory surgery in the future. The ambulatory setting offers many advantages: early mobilization, higher patient satisfaction, lower costs, and a low incidence of several c...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-020-00803-9
更新日期:2020-12-01 00:00:00
abstract::Osteoarthritis (OA) is a major cause of pain and physical disability in adults, and an increasingly common disease given its associations with aging and a growing obese/overweight population. Paracetamol is widely recommended for analgesia at an early stage in the management of OA, and, although frequently prescribed,...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.1007/s40266-019-00658-9
更新日期:2019-04-01 00:00:00
abstract:INTRODUCTION:Older cancer patients are possibly at an increased risk of medication-related problems because, typically, they receive many medications during their cancer treatment, both for the cancer itself and for supportive care. OBJECTIVES:The aim of this study was to describe the number and severity of potential ...
journal_title:Drugs & aging
pub_type: 杂志文章
doi:10.2165/11537310-000000000-00000
更新日期:2010-07-01 00:00:00
abstract::Amitriptyline is a tricyclic antidepressant agent which also has analgesic properties. Whether its analgesic effects are linked to its mood-altering activity or attributable to a discrete pharmacological action (or a combination of both) is unknown. Clinical trials demonstrate that oral amitriptyline achieves at least...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199608060-00008
更新日期:1996-06-01 00:00:00
abstract::Nitric oxide (NO) is involved in important physiological functions of the CNS, including neurotransmission, memory and synaptic plasticity. Depending on the redox state of NO, it can act as a neurotoxin or it can have a neuroprotective action. Data suggest that NO may have a role in the pathogenesis of neurodegenerati...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199812040-00001
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:To assess, by smoothness index (SI), distribution of the antihypertensive effect of extended-release (ER) felodipine over 24 hours in elderly patients with hypertension. METHODS:After a 4-week washout phase, 35 elderly patients (mean age 69 +/- 4 years) with mild-to-moderate hypertension received 2 weeks' tr...
journal_title:Drugs & aging
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2165/00002512-200219070-00007
更新日期:2002-01-01 00:00:00
abstract::Nadroparin (nadroparin calcium) is a low molecular weight heparin with a mean molecular weight of 4.5 kD. Compared with unfractionated heparin (UFH), nadroparin has a greater ratio of anti-factor Xa to anti-factor Ha activity, greater bioavailability and a longer duration of action, allowing it to be administered by s...
journal_title:Drugs & aging
pub_type: 杂志文章,评审
doi:10.2165/00002512-199710040-00006
更新日期:1997-04-01 00:00:00