Green synthesis and antimicrobial evaluation of some new trifluoromethyl-substituted hexahydropyrimidines by grinding.


:A series of trifluoromethyl-substituted hexahydropyrimidine derivatives were efficiently synthesized in excellent yields via one-pot three-component reaction of aromatic aldehydes, ethyl trifluoroacetoacetate and thiourea(urea) in presence of p-toluenesulfonic acid under solvent-free conditions at room temperature by grinding. The present method does not involve any hazardous organic solvent and has proven to be simple, efficient, environmentally benign and cost-effective compared with the classical synthetic methods. These compounds were screened for their antibacterial activities against Escherichia coli and Bacillus thuringiensis and found to exhibit remarkably better antibacterial activities than the control drug.


Eur J Med Chem


Zohdi HF,Rateb NM,Elnagdy SM




Has Abstract


2011-11-01 00:00:00














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    pub_type: 杂志文章,评审


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    abstract::A series of 36 new phenylsulfanylmethyl[1,4]naphthoquinones (7-42) were synthesized by a three-component reaction that involves lawsone, the appropriate aldehyde and thiols with variable substitution patterns. These reactions involve the in situ generation of o-quinone methides (o-QM) via Knoevenagel condensation and ...

    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Sharma A,Santos IO,Gaur P,Ferreira VF,Garcia CR,da Rocha DR

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Liu G,Xu J,Chen N,Zhang S,Ding Z,Du H

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Nishiyama T,Hatae N,Yoshimura T,Takaki S,Abe T,Ishikura M,Hibino S,Choshi T

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    journal_title:European journal of medicinal chemistry

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    journal_title:European journal of medicinal chemistry

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    journal_title:European journal of medicinal chemistry

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章,评审


    authors: Nowakowska Z

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Cheng C,Yun F,He J,Ullah S,Yuan Q

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


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    journal_title:European journal of medicinal chemistry

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Maggio B,Raimondi MV,Raffa D,Plescia F,Cascioferro S,Plescia S,Tolomeo M,Di Cristina A,Pipitone RM,Grimaudo S,Daidone G

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Metwally K,Pratsinis H,Kletsas D

    更新日期:2017-06-16 00:00:00

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    pub_type: 杂志文章


    authors: Jindal DP,Piplani P,Fajrak H,Prior C,Marshall IG

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章,评审


    authors: Rescifina A,Zagni C,Varrica MG,Pistarà V,Corsaro A

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章,评审


    authors: Tilborg A,Norberg B,Wouters J

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    journal_title:European journal of medicinal chemistry

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    journal_title:European journal of medicinal chemistry

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    authors: Bommagani S,Ponder J,Penthala NR,Janganati V,Jordan CT,Borrelli MJ,Crooks PA

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  • Selective apoptosis-inducing activity of synthetic hydrocarbon-stapled SOS1 helix with d-amino acids in H358 cancer cells expressing KRASG12C.

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Łażewska D,Kurczab R,Więcek M,Kamińska K,Satała G,Jastrzębska-Więsek M,Partyka A,Bojarski AJ,Wesołowska A,Kieć-Kononowicz K,Handzlik J

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: de la Fuente Revenga M,Herrera-Arozamena C,Fernández-Sáez N,Barco G,García-Orue I,Sugden D,Rivara S,Rodríguez-Franco MI

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  • Diversity-oriented synthesis of furo[3,2-f]chromanes with antimycobacterial activity.

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Alvey L,Prado S,Saint-Joanis B,Michel S,Koch M,Cole ST,Tillequin F,Janin YL

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    pub_type: 杂志文章


    authors: Rubio S,León F,Quintana J,Cutler S,Estévez F

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章,评审


    authors: Singh SP,Sashidhara KV

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    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Zhu H,Sun H,Liu Y,Duan Y,Liu J,Yang X,Li W,Qin S,Xu S,Zhu Z,Xu J

    更新日期:2020-12-01 00:00:00

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    abstract::Nickel(II) complexes [Ni(cur)(L)2](OAc) (1-3) where L is N,N-donor heterocyclic bases namely 1,10-phenanthroline (phen in 1), dipyrido[3,2-d:2',3'-f]quinoxaline (dpq in 2), dipyrido[3,2-a:2',3'-c]phenazine (dppz in 3) and Hcur is curcumin were prepared, fully characterized and light-induced in vitro anticancer activit...

    journal_title:European journal of medicinal chemistry

    pub_type: 杂志文章


    authors: Banaspati A,Raza MK,Goswami TK

    更新日期:2020-10-15 00:00:00