Abstract:
:A series of trifluoromethyl-substituted hexahydropyrimidine derivatives were efficiently synthesized in excellent yields via one-pot three-component reaction of aromatic aldehydes, ethyl trifluoroacetoacetate and thiourea(urea) in presence of p-toluenesulfonic acid under solvent-free conditions at room temperature by grinding. The present method does not involve any hazardous organic solvent and has proven to be simple, efficient, environmentally benign and cost-effective compared with the classical synthetic methods. These compounds were screened for their antibacterial activities against Escherichia coli and Bacillus thuringiensis and found to exhibit remarkably better antibacterial activities than the control drug.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Zohdi HF,Rateb NM,Elnagdy SMdoi
10.1016/j.ejmech.2011.09.036subject
Has Abstractpub_date
2011-11-01 00:00:00pages
5636-40issue
11eissn
0223-5234issn
1768-3254pii
S0223-5234(11)00697-0journal_volume
46pub_type
杂志文章abstract::3-(Alkyl(dialkyl)amino)benzothieno[2,3-f]quinazolin-1(2H)-ones (4-9) have been designed using Ellipticine structure as a model, replacing the carbazole core and the pyridine ring with a dibenzothiophene and a pyrimidine moiety, respectively. New benzothienoquinazolinones (4-9) have been synthesized by a simple one-pot...
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journal_title:European journal of medicinal chemistry
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