Green synthesis and antimicrobial evaluation of some new trifluoromethyl-substituted hexahydropyrimidines by grinding.

Abstract:

:A series of trifluoromethyl-substituted hexahydropyrimidine derivatives were efficiently synthesized in excellent yields via one-pot three-component reaction of aromatic aldehydes, ethyl trifluoroacetoacetate and thiourea(urea) in presence of p-toluenesulfonic acid under solvent-free conditions at room temperature by grinding. The present method does not involve any hazardous organic solvent and has proven to be simple, efficient, environmentally benign and cost-effective compared with the classical synthetic methods. These compounds were screened for their antibacterial activities against Escherichia coli and Bacillus thuringiensis and found to exhibit remarkably better antibacterial activities than the control drug.

journal_name

Eur J Med Chem

authors

Zohdi HF,Rateb NM,Elnagdy SM

doi

10.1016/j.ejmech.2011.09.036

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

5636-40

issue

11

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(11)00697-0

journal_volume

46

pub_type

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